| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4088 |
Name | SMAD3 |
Synonym | HSPC193|HsT17436|JV15-2|LDS1C|LDS3|MADH3;SMAD family member 3;SMAD3;SMAD family member 3 |
Definition | MAD homolog 3|MAD, mothers against decapentaplegic homolog 3|SMA- and MAD-related protein 3|SMAD, mothers against DPP homolog 3|hMAD-3|hSMAD3|mad homolog JV15-2|mad protein homolog|mad3|mothers against DPP homolog 3|mothers against decapentaplegic homolog |
Position | 15q22.33 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling;PID Curated;200152 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Validated targets of C-MYC transcriptional activation;PID Curated;200045 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | nfkb activation by nontypeable hemophilus influenzae;PID BioCarta;100088 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Signaling by TGF beta;Reactome;REACT:6844 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | Herpes;FunDO |
Disease | Embryoma;FunDO |
Disease | Dermatitis;FunDO |
Disease | Adenoma;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Bacteremia;GAD |
Disease | Systemic scleroderma;FunDO |
Disease | CARDIOVASCULAR;GAD |
Disease | Scleroderma;FunDO |
Disease | Coronary heart disease;NHGRI |
Disease | Coronary Disease;GAD |
Disease | Rabies;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Asthma;NHGRI |
Disease | Eating disorder;FunDO |
Disease | INFECTION;GAD |
Disease | Stomach cancer;FunDO |
External Links | |
Links to Entrez Gene | 4088 |
Links to all GeneRIF Items | 4088 |
Links to iHOP | 4088 |
Sequence Information | |
Nucleotide Sequence | >4088 : length: 6333 AGCGGGAGCGCGGCGCACGCCCCGGGCCGGCCCAGCCAGCGAGCGAGCGAGCGGCGAGCC GGGAGGAGGAGGGTGGCGGGGCGGTGAGGCCGCAGAGGCGGAGGGATCTGCGCATCAAAG CTAGCGAGGCGAGCGAAGTTTGGCCGGGGGTTGGACTTTCCTTCCCGGAGGCGGCACCCA AACAGCTACCCCGTGCGGAAACCCAAACTTCTGCTGCCACTTGGAGTCTCGCGGCCGCCG CCTCCGCCCCGCGTTCGGGGCCTTCCCGACCCTGCACTGCTGCCGTCCGCCCGCCCGGCC GCTCTTCTCTTCGCCGTGGGAGCCGCTCCGGGCGCAGGGCCGCGCGCCGAGCCCCGCAGG CTGCAGCGCCGCGGCCCGGCCCGGCGCCCCGGCAACTTCGCCGAGAGTTGAGGCGAAGTT TGGGCGACCGCGGCAGGCCCCGGCCGAGCTCCCCTCTGCGCCCCCGGCGTCCCGTCGAGC CCAGCCCCGCCGGGGGCGCTCCTCGCCGCCCGCGCGCCCTCCCCAGCCATGTCGTCCATC CTGCCTTTCACTCCCCCGATCGTGAAGCGCCTGCTGGGCTGGAAGAAGGGCGAGCAGAAC GGGCAGGAGGAGAAATGGTGCGAGAAGGCGGTCAAGAGCCTGGTCAAGAAACTCAAGAAG ACGGGGCAGCTGGACGAGCTGGAGAAGGCCATCACCACGCAGAACGTCAACACCAAGTGC ATCACCATCCCCAGGTCCCTGGATGGCCGGTTGCAGGTGTCCCATCGGAAGGGGCTCCCT CATGTCATCTACTGCCGCCTGTGGCGATGGCCAGACCTGCACAGCCACCACGAGCTACGG GCCATGGAGCTGTGTGAGTTCGCCTTCAATATGAAGAAGGACGAGGTCTGCGTGAATCCC TACCACTACCAGAGAGTAGAGACACCAGAGACCCCACCCCCTGGCTACCTGAGTGAAGAT GGAGAAACCAGTGACCACCAGATGAACCACAGCATGGACGCAGGTTCTCCAAACCTATCC CCGAATCCGATGTCCCCAGCACATAATAACTTGGACCTGCAGCCAGTTACCTACTGCGAG CCGGCCTTCTGGTGCTCCATCTCCTACTACGAGCTGAACCAGCGCGTCGGGGAGACATTC CACGCCTCGCAGCCATCCATGACTGTGGATGGCTTCACCGACCCCTCCAATTCGGAGCGC TTCTGCCTAGGGCTGCTCTCCAATGTCAACAGGAATGCAGCAGTGGAGCTGACACGGAGA CACATCGGAAGAGGCGTGCGGCTCTACTACATCGGAGGGGAGGTCTTCGCAGAGTGCCTC AGTGACAGCGCTATTTTTGTCCAGTCTCCCAACTGTAACCAGCGCTATGGCTGGCACCCG GCCACCGTCTGCAAGATCCCACCAGGATGCAACCTGAAGATCTTCAACAACCAGGAGTTC GCTGCCCTCCTGGCCCAGTCGGTCAACCAGGGCTTTGAGGCTGTCTACCAGTTGACCCGA ATGTGCACCATCCGCATGAGCTTCGTCAAAGGCTGGGGAGCGGAGTACAGGAGACAGACT GTGACCAGTACCCCCTGCTGGATTGAGCTGCACCTGAATGGGCCTTTGCAGTGGCTTGAC AAGGTCCTCACCCAGATGGGCTCCCCAAGCATCCGCTGTTCCAGTGTGTCTTAGAGACAT CAAGTATGGTAGGGGAGGGCAGGCTTGGGGAAAATGGCCATGCAGGAGGTGGAGAAAATT GGAACTCTACTCAACCCATTGTTGTCAAGGAAGAAGAAATCTTTCTCCCTCAACTGAAGG GGTGCACCCACCTGTTTTCTGAAACACACGAGCAAACCCAGAGGTGGATGTTATGAACAG CTGTGTCTGCCAAACACATTTACCCTTTGGCCCCACTTTGAAGGGCAAGAAATGGCGTCT GCTCTGGTGGCTTAAGTGAGCAGAACAGGTAGTATTACACCACCGGCCCCCTCCCCCCAG ACTCTTTTTTTGAGTGACAGCTTTCTGGGATGTCACAGTCCAACCAGAAACACCCCTCTG TCTAGGACTGCAGTGTGGAGTTCACCTTGGAAGGGCGTTCTAGGTAGGAAGAGCCCGCAG GGCCATGCAGACCTCATGCCCAGCTCTCTGACGCTTGTGACAGTGCCTCTTCCAGTGAAC ATTCCCAGCCCAGCCCCGCCCCGCCCCGCCCCACCACTCCAGCAGACCTTGCCCCTTGTG AGCTGGATAGACTTGGGATGGGGAGGGAGGGAGTTTTGTCTGTCTCCCTCCCCTCTCAGA ACATACTGATTGGGAGGTGCGTGTTCAGCAGAACCTGCACACAGGACAGCGGGAAAAATC GATGAGCGCCACCTCTTTAAAAACTCACTTACGTTTGTCCTTTTTCACTTTGAAAAGTTG GAAGGATCTGCTGAGGCCCAGTGCATATGCAATGTATAGTGTCTATTATCACATTAATCT CAAAGAGATTCGAATGACGGTAAGTGTTCTCATGAAGCAGGAGGCCCTTGTCGTGGGATG GCATTTGGTCTCAGGCAGCACCACACTGGGTGCGTCTCCAGTCATCTGTAAGAGCTTGCT CCAGATTCTGATGCATACGGCTATATTGGTTTATGTAGTCAGTTGCATTCATTAAATCAA CTTTATCATATGCTCTTTTAAATGTTTGGTTTATATATTTTCTTTAAAAATCCTGGGCTG GCACATTGACTGGGAAACCTGAGTGAGACCCAGCAACTGCTTCTCTCCCTTCTCTCTCCT GAGGTGAAGCTTTTCCAGGTTTTGTTGAAGAGATACCTGCCAGCACTTCTGCAAGCTGAA ATTTACAGAAGCAAATTCACCAGAAGGGAAACATCTCAGGCCAACATAGGCAAATGAAAA GGGCTATTAAAATATTTTTACACCTTTGAAAATTGCAGGCTTGGTACAAAGAGGTCTGTC ATCTTCCCCCTGGGATATAAGATGATCTAGCTCCCGGTAGAGGATCACCGGTGACAACTA TAGCAGTTGTATTGTGTAACAAGTACTGCTCCCAGCAGCAATTAGGGAGAAAACTAGTCT AAATTATTTCAACTGGAAAAAAGAAAAAAGAGTCCTCTTCTTTTCCCAGCCTTTTGCAGA ACACAGTAGACAGAACTGCCACCTTCAATTGGTACTTTATTCTTTGCTGCTGTTTTTGTA TAAAATGACCTATCCCACGTTTTTGCATGAATTTATAGCAGGAAAAATCAAGGGATTTCC TATGGAAGTCCTGCTTTATTCCAGGTGAAGGGAAGGAAGTGTATATACTTTTGGCAAGTC ATACAGCTCAAATGTGATGAGATTTCTGATGTTAGAGGGAGATGGAGAGGCTTCCTGATG CCTCATCTGCAGGGTCCTGTGCCTCTGAAGTTCTAGCCATGAGGTTTCCAGGTAGGACAG CTGCTCCCCAAGCCTCCTGAGGACACAGGAAGAGACGGAAGGAGCACCTTGACAGACTTG TGTGAGTCTTCTCGAAGGAGGGTTGACTCAGAACCCAGAGACAATACAAAACCCCTCACT TCCTCTGAGAGGGCCAAATGCTGTGAGTCTGAAGTATGTGCCTGGTGTGAAATGATCTAT GGCCTGTTTCTTACACAGGAAGCCCCCTGAACCTCCTGTACATGTGTTCATGTTCCCAGC CAGCTCTGAGACCCAGGAACCAAATATTCCATTTTGGCTTCTGCTAGAGCAGTCATGGTT CCTCTCCTAAAAGCCATGGGCAGCAGTTTCCGAGGGCCTGCATGATCCACCTGCTGCACG ATCCTATGAGGGCTTCCTGTGGCACACAGCCCTCTGGGTGCTTGGGAACTAGCTTCAGGC ACAGCCTGATTCTGGTGATCCAGTGATCTATGGAAGTCGTGTCTTACTCCAGGTGAAGGG GGAAAAAAAAAGCCTATACTTTGGCAGGTTATGAACTTTGAATGTGATGAAATGACACGT TTGGCTGCATTTGGATGGTGTCTTAGAACCCTCATTGCTCAGACCTGAAGGCTACTTCTA GGAGCATGAAGTTTGAGTTTTGTGTTTTTCCAAAGGATACTTCCTTGGCCCTTTTTCTTT ATTGACTAGACCACCAGAGGAGGATGTGTGGGATTGTAGGCAAACCCACCTGTGGCATCA CTGAAAATAAATTTGATCATACCTAAGAGGTTAGGAAATGGTGCCATTCCCACCTTAGAG TGCTACATAGGTGCTTTGGGCGTATGTAACATTAGTGTCCTTCCTTGAAGCCACAAGCTA GTTTTCTTAGTTTTAAAATCCTGTTGTATGAATGGCATTTGTATATTAAAACACTTTTTT AAAGGACAGTTGAAAAGGGCAAGAGGAAACCAGGGCAGTTCTAGAGGAGTGCTGGTGACT GGATAGCAGTTTTAAGTGGCGTTCACCTAGTCAACACGACCGCGTGTGTTGCCCCTGCCC TGGGCTCCCCGCCATGACATCTTCACCTTGCAGCTTGTGCTGAGACTGACCCAAGTGCAG CTAGCACTGGGACACAGATCCTTGTCTTCAGCACCTTCCAAGGAGCCAACTTTTATTCCC TTTCCTCTCTCCCCTCCCCACCTCGCTTCTTCCCAATTTAGTAACTTAGATGCTTCCAGC ACATACGTAGGTAGCTACCCCAGCCGGTTTGGATTACAGGCCTGTGCTGGAACATCATCT CAGTTGGCCACCTTCCTGGCAGGCTGTAGACCTGACATTTTGAGACAAGCCTAGAGGAGT CAGGAGCAGGGACTTTGACTCTTAGGAAGAGCACACATGAGGGCAAGGCTGCTGGCAGAC GTCTCCATTGTCCTTATGTTGTCTGTGTTGTATTTTTTTTTTTTTATTGACCATGGTGAT TATTTTTTTAAACCATCGTTAATATACTGAAGTGAGCTATAGCACATATCATGTGCTTAG TTTGTTTATTTTTCTCCATCTCCCCTTGGCTTCCTAGAGTTTGGACATATTCCAGGCTAA ATGCTTTTACTCAAGACTACAGAAAGGTTTGAAGTAGTGTGTGCATGGCATGCACGTATG TAAGTAATCTGGGGAAGAAGCAAAGATCTGTTTCATTCTTAGCCTCAGGCCTCATGAGGG TCTCCACAGGGCCGGAGCTCAGGTTACACCACTCCTTCGTCCTTACAGGAGATGTAGGGA GAAGAATCTGCAGGCTGCTTGTAGGACTGTTCACCAAGGGGGATACCAGCAGCAAGAGAG TGCACCCGTTTAGCCCTGGACCCTGTTTCTTACTGTGTGACTTGGCTAGAGTTGGGAGTT CCCCCAAAATAAACGTGTCCCCATTTTACCAGAACCAAACCTCAACACAGCGAAGCTGTA CTGTCTTTGTGTGGCAAAGATGTTCCCTTGTAGGCCCCTTTCAGGTAACCGTCTTCACAA TGTATTTTCATCACAGTTTAAGGAGCATCAGCCGCTTCTCAAGTGGGTAGGGAAAGCAGA AAAACGTACGCAAGAGGACATGGATCCAAAATGATGATGAAGCATCTCCCATGGGGAGGT GATGGTGGGGAGATGATGGGCTAAACAGGCAACTTTTCAAAAACACAGCTATCATAGAAA AGAAACTTGCCTCATGTAAACTGGATTGAGAAATTCTCAGTGATTCTGCAATGGATTTTT TTTTAATGCAGAAGTAATGTATACTCTAGTATTCTGGTGTTTTTATATTTATGTAATAAT TTCTTAAAACCATTCAGACAGATAACTATTTAATTTTTTTTAAGAAAGTTGGAAAGGTCT CTCCTCCCAAGGACAGTGGCTGGAAGAGTTGGGGCACAGCCAGTTCTGAATGTTGGTGGA GGGTGTAGTGGCTTTTTGGCTCAGCATCCAGAAACACCAAACCAGGCTGGCTAAACAAGT GGCCGCGTGTAAAAACAGACAGCTCTGAGTCAAATCTGGGCCCTTCCACAAGGGTCCTCT GAACCAAGCCCCACTCCCTTGCTAGGGGTGAAAGCATTACAGAGAGATGGAGCCATCTAT CCAAGAAGCCTTCACTCACCTTCACTGCTGCTGTTGCAACTCGGCTGTTCTGGACTCTGA TGTGTGTGGAGGGATGGGGAATAGAACATTGACTGTGTTGATTACCTTCACTATTCGGCC AGCCTGACCTTTTAATAACTTTGTAAAAAGCATGTATGTATTTATAGTGTTTTAGATTTT TCTAACTTTTATATCTTAAAAGCAGAGCACCTGTTTAAGCATTGTACCCCTATTGTTAAA GATTTGTGTCCTCTCATTCCCTCTCTTCCTCTTGTAAGTGCCCTTCTAATAAACTTTTCA TGGAAAAGCTCCTGTGCCAGGAGCTCAGTCTGA |
Protein Sequence | >4088 : length: 425 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR CSSVS |