| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 23411 |
Name | SIRT1 |
Synonym | SIR2|SIR2L1|hSIR2;sirtuin 1;SIRT1;sirtuin 1 |
Definition | NAD-dependent deacetylase sirtuin-1|NAD-dependent protein deacetylase sirtuin-1|SIR2-like protein 1|SIR2alpha|regulatory protein SIR2 homolog 1|sir2-like 1|sirtuin type 1 |
Position | 10q21.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | regulation of transcriptional activity by pml;PID BioCarta;100067 |
Pathway | HIF-2-alpha transcription factor network;PID Curated;200030 |
Pathway | FoxO family signaling;PID Curated;200091 |
External Links | |
Links to Entrez Gene | 23411 |
Links to all GeneRIF Items | 23411 |
Links to iHOP | 23411 |
Sequence Information | |
Nucleotide Sequence | >23411 : length: 4110 GTCGAGCGGGAGCAGAGGAGGCGAGGGAGGAGGGCCAGAGAGGCAGTTGGAAGATGGCGG ACGAGGCGGCCCTCGCCCTTCAGCCCGGCGGCTCCCCCTCGGCGGCGGGGGCCGACAGGG AGGCCGCGTCGTCCCCCGCCGGGGAGCCGCTCCGCAAGAGGCCGCGGAGAGATGGTCCCG GCCTCGAGCGGAGCCCGGGCGAGCCCGGTGGGGCGGCCCCAGAGCGTGAGGTGCCGGCGG CGGCCAGGGGCTGCCCGGGTGCGGCGGCGGCGGCGCTGTGGCGGGAGGCGGAGGCAGAGG CGGCGGCGGCAGGCGGGGAGCAAGAGGCCCAGGCGACTGCGGCGGCTGGGGAAGGAGACA ATGGGCCGGGCCTGCAGGGCCCATCTCGGGAGCCACCGCTGGCCGACAACTTGTACGACG AAGACGACGACGACGAGGGCGAGGAGGAGGAAGAGGCGGCGGCGGCGGCGATTGGGTACC GAGATAACCTTCTGTTCGGTGATGAAATTATCACTAATGGTTTTCATTCCTGTGAAAGTG ATGAGGAGGATAGAGCCTCACATGCAAGCTCTAGTGACTGGACTCCAAGGCCACGGATAG GTCCATATACTTTTGTTCAGCAACATCTTATGATTGGCACAGATCCTCGAACAATTCTTA AAGATTTATTGCCGGAAACAATACCTCCACCTGAGTTGGATGATATGACACTGTGGCAGA TTGTTATTAATATCCTTTCAGAACCACCAAAAAGGAAAAAAAGAAAAGATATTAATACAA TTGAAGATGCTGTGAAATTACTGCAAGAGTGCAAAAAAATTATAGTTCTAACTGGAGCTG GGGTGTCTGTTTCATGTGGAATACCTGACTTCAGGTCAAGGGATGGTATTTATGCTCGCC TTGCTGTAGACTTCCCAGATCTTCCAGATCCTCAAGCGATGTTTGATATTGAATATTTCA GAAAAGATCCAAGACCATTCTTCAAGTTTGCAAAGGAAATATATCCTGGACAATTCCAGC CATCTCTCTGTCACAAATTCATAGCCTTGTCAGATAAGGAAGGAAAACTACTTCGCAACT ATACCCAGAACATAGACACGCTGGAACAGGTTGCGGGAATCCAAAGGATAATTCAGTGTC ATGGTTCCTTTGCAACAGCATCTTGCCTGATTTGTAAATACAAAGTTGACTGTGAAGCTG TACGAGGAGATATTTTTAATCAGGTAGTTCCTCGATGTCCTAGGTGCCCAGCTGATGAAC CGCTTGCTATCATGAAACCAGAGATTGTGTTTTTTGGTGAAAATTTACCAGAACAGTTTC ATAGAGCCATGAAGTATGACAAAGATGAAGTTGACCTCCTCATTGTTATTGGGTCTTCCC TCAAAGTAAGACCAGTAGCACTAATTCCAAGTTCCATACCCCATGAAGTGCCTCAGATAT TAATTAATAGAGAACCTTTGCCTCATCTGCATTTTGATGTAGAGCTTCTTGGAGACTGTG ATGTCATAATTAATGAATTGTGTCATAGGTTAGGTGGTGAATATGCCAAACTTTGCTGTA ACCCTGTAAAGCTTTCAGAAATTACTGAAAAACCTCCACGAACACAAAAAGAATTGGCTT ATTTGTCAGAGTTGCCACCCACACCTCTTCATGTTTCAGAAGACTCAAGTTCACCAGAAA GAACTTCACCACCAGATTCTTCAGTGATTGTCACACTTTTAGACCAAGCAGCTAAGAGTA ATGATGATTTAGATGTGTCTGAATCAAAAGGTTGTATGGAAGAAAAACCACAGGAAGTAC AAACTTCTAGGAATGTTGAAAGTATTGCTGAACAGATGGAAAATCCGGATTTGAAGAATG TTGGTTCTAGTACTGGGGAGAAAAATGAAAGAACTTCAGTGGCTGGAACAGTGAGAAAAT GCTGGCCTAATAGAGTGGCAAAGGAGCAGATTAGTAGGCGGCTTGATGGTAATCAGTATC TGTTTTTGCCACCAAATCGTTACATTTTCCATGGCGCTGAGGTATATTCAGACTCTGAAG ATGACGTCTTATCCTCTAGTTCTTGTGGCAGTAACAGTGATAGTGGGACATGCCAGAGTC CAAGTTTAGAAGAACCCATGGAGGATGAAAGTGAAATTGAAGAATTCTACAATGGCTTAG AAGATGAGCCTGATGTTCCAGAGAGAGCTGGAGGAGCTGGATTTGGGACTGATGGAGATG ATCAAGAGGCAATTAATGAAGCTATATCTGTGAAACAGGAAGTAACAGACATGAACTATC CATCAAACAAATCATAGTGTAATAATTGTGCAGGTACAGGAATTGTTCCACCAGCATTAG GAACTTTAGCATGTCAAAATGAATGTTTACTTGTGAACTCGATAGAGCAAGGAAACCAGA AAGGTGTAATATTTATAGGTTGGTAAAATAGATTGTTTTTCATGGATAATTTTTAACTTC ATTATTTCTGTACTTGTACAAACTCAACACTAACTTTTTTTTTTTTAAAAAAAAAAAGGT ACTAAGTATCTTCAATCAGCTGTTGGTCAAGACTAACTTTCTTTTAAAGGTTCATTTGTA TGATAAATTCATATGTGTATATATAATTTTTTTTGTTTTGTCTAGTGAGTTTCAACATTT TTAAAGTTTTCAAAAAGCCATCGGAATGTTAAATTAATGTAAAGGGAACAGCTAATCTAG ACCAAAGAATGGTATTTTCACTTTTCTTTGTAACATTGAATGGTTTGAAGTACTCAAAAT CTGTTACGCTAAACTTTTGATTCTTTAACACAATTATTTTTAAACACTGGCATTTTCCAA AACTGTGGCAGCTAACTTTTTAAAATCTCAAATGACATGCAGTGTGAGTAGAAGGAAGTC AACAATATGTGGGGAGAGCACTCGGTTGTCTTTACTTTTAAAAGTAATACTTGGTGCTAA GAATTTCAGGATTATTGTATTTACGTTCAAATGAAGATGGCTTTTGTACTTCCTGTGGAC ATGTAGTAATGTCTATATTGGCTCATAAAACTAACCTGAAAAACAAATAAATGCTTTGGA AATGTTTCAGTTGCTTTAGAAACATTAGTGCCTGCCTGGATCCCCTTAGTTTTGAAATAT TTGCCATTGTTGTTTAAATACCTATCACTGTGGTAGAGCTTGCATTGATCTTTTCCACAA GTATTAAACTGCCAAAATGTGAATATGCAAAGCCTTTCTGAATCTATAATAATGGTACTT CTACTGGGGAGAGTGTAATATTTTGGACTGCTGTTTTCCATTAATGAGGAGAGCAACAGG CCCCTGATTATACAGTTCCAAAGTAATAAGATGTTAATTGTAATTCAGCCAGAAAGTACA TGTCTCCCATTGGGAGGATTTGGTGTTAAATACCAAACTGCTAGCCCTAGTATTATGGAG ATGAACATGATGATGTAACTTGTAATAGCAGAATAGTTAATGAATGAAACTAGTTCTTAT AATTTATCTTTATTTAAAAGCTTAGCCTGCCTTAAAACTAGAGATCAACTTTCTCAGCTG CAAAAGCTTCTAGTCTTTCAAGAAGTTCATACTTTATGAAATTGCACAGTAAGCATTTAT TTTTCAGACCATTTTTGAACATCACTCCTAAATTAATAAAGTATTCCTCTGTTGCTTTAG TATTTATTACAATAAAAAGGGTTTGAAATATAGCTGTTCTTTATGCATAAAACACCCAGC TAGGACCATTACTGCCAGAGAAAAAAATCGTATTGAATGGCCATTTCCCTACTTATAAGA TGTCTCAATCTGAATTTATTTGGCTACACTAAAGAATGCAGTATATTTAGTTTTCCATTT GCATGATGTTTGTGTGCTATAGATGATATTTTAAATTGAAAAGTTTGTTTTAAATTATTT TTACAGTGAAGACTGTTTTCAGCTCTTTTTATATTGTACATAGTCTTTTATGTAATTTAC TGGCATATGTTTTGTAGACTGTTTAATGACTGGATATCTTCCTTCAACTTTTGAAATACA AAACCAGTGTTTTTTACTTGTACACTGTTTTAAAGTCTATTAAAATTGTCATTTGACTTT TTTCTGTTAACTTAAAAAAAAAAAAAAAAA |
Protein Sequence | >23411 : length: 747 MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD GDDQEAINEAISVKQEVTDMNYPSNKS |