| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 80204 |
Name | FBXO11 |
Synonymous | F-box protein 11;FBXO11;F-box protein 11 |
Definition | F-box only protein 11|protein arginine N-methyltransferase 9|ubiquitin protein ligase E3 component n-recognin 6|vitiligo-associated protein 1|vitiligo-associated protein VIT-1 |
Position | 2p16.3 |
Gene type | protein-coding |
Title | Abstract |
| miscellaneous | metastatic dissemination is often initiated by the reactivation of an embryonic development program referred to as epithelial-mesenchymal transition (EMT). The transcription factor SNAIL promotes EMT and elicits associated pathological characteristics such as invasion, metastasis, and stemness. To better understand the posttranslational regulation of SNAIL, we performed a luciferase-based, genome-wide E3 ligase siRNA library screen and identified SCF-FBXO11 as an important E3 that targets SNAIL for ubiquitylation and degradation. Furthermore, we discovered that SNAIL degradation by FBXO11 is dependent on Ser-11 phosphorylation of SNAIL by protein kinase D1 (PKD1). FBXO11 blocks SNAIL-induced EMT, tumor initiation, and metastasis in multiple breast cancer models. These findings establish the PKD1-FBXO11-SNAIL axis as a mechanism of posttranslational regulation of EMT and cancer metastasis. |