7532

YWHAG

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma;YWHAG;tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

14-3-3 gamma|14-3-3 protein gamma|KCIP-1|protein kinase C inhibitor protein 1|protein phosphatase 1, regulatory subunit 170|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

7q11.23

protein-coding

The 14-3-3gamma protein is an important regulator of various cellular and physiologic functions. Overexpression promotes cell proliferation and induces cancer cell polyploidization. Production is up-regulated in human hepatocellular carcinoma. However, the clinical significance of 14-3-3gamma for human hepatocellular carcinoma metastasis and survival has not been clarified. In this study, 55 patients with human hepatocellular carcinoma were enrolled; and 18 of them were identified as having extrahepatic metastases. expression of 14-3-3gamma in these primary and metastatic samples was measured with semiquantitative immunohistochemistry analysis. Overexpression of 14-3-3gamma was observed in 38 (69.1%) of the primary tumors, correlated significantly with a high alpha-fetoprotein concentration (P = .003), and predicted a higher probability of extrahepatic metastasis (cumulative probabilities at 5 years: 42.2% +/- 8.0% versus 5.9% +/- 5.7%, 14-3-3gamma positive versus negative; P = .012). Furthermore, 14-3-3gamma overexpression was associated with a worse 5-year overall survival rate (81.6% +/- 9.6% versus 59.5% +/- 8.1%, respectively) and a worse 5-year progression-free survival rate (75.6% +/- 10.6% versus 48.6% +/- 8.2%, respectively). Elevated expression of 14-3-3gamma in human hepatocellular carcinoma predicts extrahepatic metastasis and worse survival. The protein thus is a candidate biomarker and a potential target for novel therapies against human hepatocellular carcinoma progression and metastasis.