| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5954 |
Name | RCN1 |
Synonymous | reticulocalbin 1, EF-hand calcium binding domain;RCN1;reticulocalbin 1, EF-hand calcium binding domain |
Definition | epididymis secretory protein Li 84|proliferation-inducing gene 20|reticulocalbin-1 |
Position | 11p13 |
Gene type | protein-coding |
Title | Abstract |
| lung cancer | Lymphatic endothelial cells in tumors (T-LECs) are considered to have different characteristics from LECs in non-tumor tissues (N-LECs). However, differences between the two types have not been well analyzed at molecular level. In this report, we performed differential proteome analysis of T-LEC and N-LEC models prepared by cultivation of LECs in tumor conditioned medium. By expression profiling of identified proteins using tissue microarrays, reticulocalbin-1 was found to be expressed in clinical specimen-derived T-LECs and lung cancer cells but not N-LECs. It is suggested that reticulocalbin-1 may be an important molecule in understanding T-LEC function and control of lymphatic metastasis. |