| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4684 |
Name | NCAM1 |
Synonymous | neural cell adhesion molecule 1;NCAM1;neural cell adhesion molecule 1 |
Definition | antigen recognized by monoclonal antibody 5.1H11|neural cell adhesion molecule, NCAM |
Position | 11q23.1 |
Gene type | protein-coding |
Title | Abstract |
| thyroid cancer | We previously showed that the preservation of neural adhesion molecule (NCAM) in differentiated thyroid carcinoma is an important indicator for a higher risk of distant metastasis. In the present study, we further demonstrated that forced NCAM-140 isoform expression in human thyroid cancer cells could lead to aggressive growth by enhancing migration and anchorage-independent growth, and exhibiting partial features of epithelial mesenchymal transition. More extensive distant metastasis was also noted in an animal xenograft model when NCAM-expressing thyroid cancer cells were introduced into mice intravascularly. Bioinformatic analysis of NCAM-associated expression profiles predicted a highly interactive protein network, which further implies potential molecular mechanisms underlying the metastatic processes of thyroid cancer. |