| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3326 |
Name | HSP90AB1 |
Synonymous | heat shock protein 90kDa alpha (cytosolic), class B member 1;HSP90AB1;heat shock protein 90kDa alpha (cytosolic), class B member 1 |
Definition | HSP90-beta|heat shock 84 kDa|heat shock 90kD protein 1, beta|heat shock protein HSP 90-beta |
Position | 6p12 |
Gene type | protein-coding |
Title | Abstract |
| lung cancer | BACKGROUND: Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and annexin A1 in lung cancer and normal lung specimens were examined, and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed. METHODS: The expression levels of Hsp90-beta and annexin A1 were examined using immunohistochemistry, in-situ hybridization, and Western blot. RESULTS: Lung cancer tissues exhibited higher expression levels of Hsp90-beta and annexin A1 than the normal tissues (p < 0.05), and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p < 0.05). Moreover, the upregulation of Hsp90-beta and annexin A1 correlated with decreased survival (p < 0.05). CONCLUSION: The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. Moreover, the high expression of the markers was an independent predictor of poor outcomes. |