| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 27122 |
Name | DKK3 |
Synonymous | dickkopf WNT signaling pathway inhibitor 3;DKK3;dickkopf WNT signaling pathway inhibitor 3 |
Definition | RIG-like 5-6|RIG-like 7-1|dickkopf 3 homolog|dickkopf homolog 3|dickkopf-3|dickkopf-related protein 3|dkk-3|hDkk-3|regulated in glioma |
Position | 11p15.2 |
Gene type | protein-coding |
Title | Abstract |
| esophageal cancer | OBJECTIVE: To investigate the expression of Dickkopf-3 (Dkk-3) in esophageal cancer and normal esophageal tissue and the relationship between Dkk-3 expression and the biological behavior of esophageal cancer. METHODS: Immunohistochemical method of S-P was used to examine Dkk-3 expression in 69 cases of esophageal squamous cell carcinoma and 5 cases of normal esophageal tissue with non-tumor tissue microarray and the results were analyzed and correlated with their clinical and pathological features. RESULTS: Positive Dkk-3 expression was observed in 65.7% (44/67) of the esophageal squamous cell carcinoma cases, but only one of the five cases with normal esophageal tissue showed positive microvascular expression of Dkk-3. In cases with positive expression of Dkk-3 significant differences were found in fiber membrane infiltration, depth of invasion, lymph node metastasis and TNM staging (P < 0.05), while no significant differences were found in the age, gender and pathological grading (P > 0.05). CONCLUSIONS: The upregulation of Dkk-3 expression in esophageal squamous cell carcinoma may contribute to tumor invasion and metastasis. |