26762

HAVCR1

hepatitis A virus cellular receptor 1;HAVCR1;hepatitis A virus cellular receptor 1

T cell immunoglobin domain and mucin domain protein 1|T-cell immunoglobulin mucin family member 1|T-cell immunoglobulin mucin receptor 1|T-cell membrane protein 1|kidney injury molecule 1

5q33.2

protein-coding

OBJECTIVE: To study the expression and clinical significance of kidney injury molecule-1 (KIM-1) in primary and metastatic renal epithelial neoplasms. METHODS: A total of 136 cases of kidney neoplasms were retrospectively reviewed including 63 primary clear cell renal cell carcinomas (RCCs), 22 papillary RCCs, 13 chromophobe RCCs, 7 oncocytomas, 7 RCCs associated with Xp11.2 translocation/TFE3 gene fusions and 24 metastatic clear cell RCCs. Immunostaining for KIM-1 and kidney-specific-protein (Ksp)-cadherin were performed and the relationship to tumor stage and grade in clear cell RCCs was investigated. RESULTS: expression of KIM-1 was detected in 77.8% (49/63) of clear cell RCCs, 90.9% (20/22) of papillary RCCs, 1/13 of chromophobe RCCs, 7/7 of RCCs associated with Xp11.2 translocation/TFE3 gene fusions and 87.5%(21/24) of the metastatic RCCs, but not detected in 7 cases of oncocytomas. A diffuse expression of KIM-1 was more frequently observed in Furhman nuclear grade III/IV clear cell RCCs (P = 0.010). Ksp-cadherin expression was mainly observed in chromophobe RCCs and oncocytomas. CONCLUSIONS: KIM-1 is a specific biomarker for injuried kidney proximal tubules and the corresponding neoplasms, and has a high specificity and sensitivity for primary or metastatic clear cell RCCs, papillary RCCs and RCCs associated with Xp11.2 translocation/TFE3 gene fusions. Combination of KIM-1 and Ksp-cadherin immunostaining can lead to a more precise histological classification of primary kidney epithelial neoplasms and improve the diagnostic accuracy of metastatic RCCs.

BACKGROUND: Hepatitis A virus cellular receptor 1 (HAVcR-1) may function as part of the regulatory apparatus for tight junction in human endothelial cells, and is overexpressed in renal cell and ovarian clear cell carcinomas. MATERIALS AND METHODS: HAVcR-1 expression in colorectal cancer and matched background tissues was determined using quantitative-PCR. HAVcR-1 was overexpressed in three colorectal cancer cell lines and the effect of this overexpression was assessed by changes in cell behaviour. RESULTS: HAVcR-1 expression was increased in colorectal cancer (p<0.001) and the disease-free time of patients with high levels of HAVcR-1 expression was significantly longer (p=0.045). HAVcR-1 overexpression reduced colorectal cancer cell adhesion and invasion (p<0.016). CONCLUSION: HAVcR-1 overexpression may be a diagnostic biomarker for colorectal cancer and a prognostic marker for a longer disease-free interval after surgery for colorectal cancer. HAVcR-1 overexpression can reduce cell adhesion and invasion and could thus be involved in the metastatic cascade.