| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 23468 |
Name | CBX5 |
Synonymous | chromobox homolog 5;CBX5;chromobox homolog 5 |
Definition | HP1 alpha homolog|HP1-ALPHA|HP1Hs alpha|antigen p25|chromobox homolog 5 (HP1 alpha homolog, Drosophila)|chromobox protein homolog 5|epididymis luminal protein 25|heterochromatin protein 1 homolog alpha|heterochromatin protein 1-alpha |
Position | 12q13.13 |
Gene type | protein-coding |
Title | Abstract |
| thyroid cancer | Owing to the loss of heterochromatin integrity that occurs during thyroid tumorigenesis, the expression of Heterochromatin Protein 1 isoforms HP1alpha and HP1beta was assessed by immunohistochemistry in 189 thyroid tumors and non-neoplastic tissues. expression of HP1beta was significantly decreased in all thyroid lesions, except in follicular adenomas, when compared with matched adjacent normal tissue. This loss of HP1beta expression may in part be caused by microRNA dysregulation. An example is miR-205, a microRNA that is abundantly upregulated in thyroid carcinomas and shown to reduce the expression of HP1beta. In contrast to HP1beta, HP1alpha expression was only reduced in metastatic carcinomas and poorly differentiated lesions. These results suggest the reduction of HP1beta followed by a decrease in HP1alpha contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively. |