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Cancer metastasis database
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Basic Information

Gene ID

23284

Name

ADGRL3

Synonymous

adhesion G protein-coupled receptor L3;ADGRL3;adhesion G protein-coupled receptor L3

Definition

CIRL-3|calcium-independent alpha-latrotoxin receptor 3|latrophilin 3|latrophilin homolog 3 (cow)|latrophilin-3|lectomedin 3

Position

4q13.1

Gene type

protein-coding

Title

Abstract

breast cancer

Breast cancer is the leading cause of cancer deaths among women worldwide, including Thailand. In the present study, the differential mRNA expression of SVEP1, LPHN3, KLB, ITGA7, SEMA3G, TNS1 and MMP13 genes was examined in breast cancer using quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR). Among these genes, increased LPHN3 and MMP13 mRNA expression levels correlated with axillary-node metastasis (P=0.02). Multiple logistic regression analysis revealed that LPHN3 and MMP13 mRNA expression is significantly associated with axillary node status in breast cancer (P=0.04).