| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 10383 |
Name | TUBB4B |
Synonymous | tubulin, beta 4B class IVb;TUBB4B;tubulin, beta 4B class IVb |
Definition | class IVb beta tubulin|class IVb beta-tubulin|tubulin beta-2 chain|tubulin beta-2C chain|tubulin beta-4B chain|tubulin, beta 2C|tubulin, beta, 2 |
Position | 9q34 |
Gene type | protein-coding |
Title | Abstract |
| colorectal cancer | AIM: To investigate the early metastasis-associated proteins in sentinel lymph node micrometastasis (SLNMM) of colorectal cancer (CRC) through comparative proteome. METHODS: Hydrophobic protein samples were extracted from individual-matched normal lymph nodes (NLN) and SLNMM of CRC. Differentially expressed protein spots were detected by two-dimensional electrophoresis and image analysis, and subsequently identified by matrix assisted laser desorption/ionization-time of flight mass spectrometry-mass spectrometry and Western blotting, respectively. RESULTS: Forty proteins were differentially expressed in NLN and SLNMM, and 4 metastasis-concerned proteins highly expressed in SLNMM were identified to be hnRNP A1, Ezrin, tubulin beta-2C and Annexin A1. Further immunohistochemistry staining of these four proteins showed their clinicopathological characteristics in lymph node metastasis of CRC. CONCLUSION: Variations of hydrophobic protein expression in NLN and SLNMM of CRC and increased expression of hnRNP A1, Ezrin, tubulin beta-2C and Annexin A1 in SLNMM suggest a significantly elevated early CRC metastasis. |