| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 9891 |
Name | NUAK1 |
Synonymous | NUAK family, SNF1-like kinase, 1;NUAK1;NUAK family, SNF1-like kinase, 1 |
Definition | AMP-activated protein kinase family member 5|AMPK-related protein kinase 5|NUAK family SNF1-like kinase 1|omphalocele kinase 1 |
Position | 12q23.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | nuak1(h) + ATP --LKB1(m):STRADalpha(h):MO25(h)--> nuak1(h){pT211} + ADP (phosphorylation) | nuak1(h) + ATP --LKB1(m):STRADalpha(h):MO25beta(h)--> nuak1(h){pT211} + ADP (phosphorylation) | nuak1(h) + ATP --LKB1(m):STRADbeta(h):MO25(h)--> nuak1(h){pT211} + ADP (phosphorylation) | nuak1(h) + IGHA-2(h) <==> nuak1(h):IGHA-2(h) (binding) | nuak1(h) + PAP39(h) <==> nuak1(h):PAP39(h) (binding) | nuak1(h) + K1B(h) <==> nuak1(h):K1B(h) (binding) | nuak1(h) + MRP-8(h) <==> nuak1(h):MRP-8(h) (binding) | nuak1(h) + PKA-RI-alpha(h) <==> nuak1(h):PKA-RI-alpha(h) (binding) | nuak1(h) + MRP-14(h) <==> nuak1(h):MRP-14(h) (binding) | NUAK1(h) --> nuak1(h) (expression). | Hsp70-1(h) + nuak1(h) <==> Hsp70-1(h):nuak1(h) (binding) | NUAK1(h) --> nuak1(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 211 | Phosphothreonine. | Swiss-Prot 53.0 | 215 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 371 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 380 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 600 | Phosphoserine (by PKB/AKT1). | Swiss-Prot 53.0 | 211 | Phosphothreonine (LKB1) | 14976552 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 105057441 - 105059441 | GSE27584 |
chr12 |
Promoter: 105057441 - 105059441 | Agilent_014791_44K |