Entrez Gene

Basic Information
Gene ID	972
Name	CD74
Synonymous	CD74 molecule, major histocompatibility complex, class II invariant chain;CD74;CD74 molecule, major histocompatibility complex, class II invariant chain
Definition	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)\|HLA class II histocompatibility antigen gamma chain\|HLA-DR antigens-associated invariant chain\|HLA-DR-gamma\|Ia-associated invariant chain\|MHC HLA-DR gamm
Position	5q32
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
CD74(h) --> DHLAG-isoformL(h) (expression).
GIF(m.s.) + DHLAG(h) <==> GIF(m.s.):DHLAG(h) (binding)
cxcr4(h) + DHLAG(h) <==> cxcr4(h):DHLAG(h) (binding)
FCRN(h) + DHLAG(h) <==> FCRN(h):DHLAG(h) (binding)
CD74(h) --> DHLAG(h) (expression).
CD74(h) --> DHLAG-isoformS(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
130	N-linked (GlcNAc...).		Swiss-Prot 53.0
136	N-linked (GlcNAc...).		Swiss-Prot 53.0
282	O-linked (Xyl...) (glycosaminoglycan)(Potential).		Swiss-Prot 53.0
25	Phosphoserine	2507633	Phospho.ELM 6.0
42	Phosphoserine	2507633	Phospho.ELM 6.0
45	Phosphoserine	2507633	Phospho.ELM 6.0
282	O-linked	Nguyen QV., Knapp W., Humpreys RE. (1993)Mol. Immunol., 30, 1679-1684. Medline: 94097362;	OGlycBase6.0
203	O-linked	Nguyen QV., Knapp W., Humpreys RE. (1993)Mol. Immunol., 30, 1679-1684. Medline: 94097362;	OGlycBase6.0
130	N-liked	Nguyen QV., Knapp W., Humpreys RE. (1993)Mol. Immunol., 30, 1679-1684. Medline: 94097362;	OGlycBase6.0
136	N-liked	Nguyen QV., Knapp W., Humpreys RE. (1993)Mol. Immunol., 30, 1679-1684. Medline: 94097362;	OGlycBase6.0

Transcription Factors [Top]