| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 9612 |
Name | NCOR2 |
Synonymous | nuclear receptor corepressor 2;NCOR2;nuclear receptor corepressor 2 |
Definition | CTG repeat protein 26|T3 receptor-associating factor|silencing mediator for retinoid and thyroid hormone receptors|thyroid-, retinoic-acid-receptor-associated corepressor |
Position | 12q24 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | SKIP(h) + SMRT(h) <==> SKIP(h):SMRT(h) (binding) | SMRT(h) + NR1B1-isoform1(h) <==> SMRT(h):NR1B1-isoform1(h) (binding). | SMRT(h) + arnt(h) <==> SMRT(h):arnt(h) (binding) | SMRT(h) + AhR(m) <==> SMRT(h):AhR(m) (binding) | SMRT(h) + AhR(m):arnt(h) <==> SMRT(h):AhR(m):arnt(h) (binding) | SMRT(h) + T3R-alpha1(h) <==> SMRT(h):T3R-alpha1(h) (binding) | SMRT(h) + T3R-beta(m.s.) <==> SMRT(h):T3R-beta(m.s.) (binding) | NCOR1(h) + SMRT(h) + mbd3(h) + MTA1L1(h) + Sin3B(h) + sin3a(h) + HDAC1(h) + RbAp46(h) + RbAp48(h) + HDAC7(m) <==> NCOR1(h):SMRT(h):mbd3(h):MTA1L1(h):Sin3B(h):sin3a(h):HDAC1(h):RbAp46(h):RbAp48(h):HDAC7(m) (binding) | TBLR1(m.s.) + SMRT(h) <==> TBLR1(m.s.):SMRT(h) (binding) | HDAC7(h) + SMRT(h) <==> HDAC7(h):SMRT(h) (binding) | SMRT(h) + HDAC3(h) <==> SMRT(h):HDAC3(h) (binding) | SMRT(h) + PXR-isoform1A(h) <==> SMRT(h):PXR-isoform1A(h) (binding) | SMRT(h) + PXR(m) <==> SMRT(h):PXR(m) (binding) | SMRT(h) + LXR-beta(h) <==> SMRT(h):LXR-beta(h) (binding) | SMRT(h) + COUP-TF1(m) <==> SMRT(h):COUP-TF1(m) (binding) | SMRT(h) + COUP-TF2(m) <==> SMRT(h):COUP-TF2(m) (binding) | SMRT(h) + Rev-ErbAalpha(m.s.) <==> SMRT(h):Rev-ErbAalpha(m.s.) (binding) | SMRT(h) + CAR(m) <==> SMRT(h):CAR(m) (binding) | SMRT(h) + FXR(h) <==> SMRT(h):FXR(h) (binding) | SMRT(h) + PPARgamma(m) <==> SMRT(h):PPARgamma(m) (binding) | SMRT(h) + NR1B1(h) <==> SMRT(h):NR1B1(h) (binding) | SMRT(h) --/ CYP3A4(h) (transrepression) | SMRT(h) + PPARgamma(m.s.) <==> SMRT(h):PPARgamma(m.s.) (binding) | SMRT(h) + T3R-beta1(h) <==> SMRT(h):T3R-beta1(h) (binding) | NR1B1(m.s.) + SMRT(h) <==> NR1B1(m.s.):SMRT(h) (binding) | SMRT(h) + HDAC3(h) + Ebi(h) <==> SMRT(h):HDAC3(h):Ebi(h) (binding) | TBLR1(h) + SMRT(h) <==> TBLR1(h):SMRT(h) (binding) | PLZF(h) + SMRT(h) <==> PLZF(h):SMRT(h) (binding) | SMRT(h) + BCL-6(m.s.) <==> SMRT(h):BCL-6(m.s.) (binding) | Ebi(m.s.) + SMRT(h) <==> Ebi(m.s.):SMRT(h) (binding) | HDAC3(m.s.) + SMRT(h) <==> HDAC3(m.s.):SMRT(h) (binding) | Ebi(m.s.) + HDAC3(m.s.) + SMRT(h) <==> Ebi(m.s.):HDAC3(m.s.):SMRT(h) (binding) | LXRalpha-isoform1(h) + SMRT(h) <==> LXRalpha-isoform1(h):SMRT(h) (binding) | SMRT(h) + Prp6(h) + PRP4K(h) + BRG1(h) <==> SMRT(h):Prp6(h):PRP4K(h):BRG1(h) (binding) | SMRT(h) + GPS2(h) + TBLR1(h) + HDAC3(h) + Ebi(h) <==> SMRT(h):GPS2(h):TBLR1(h):HDAC3(h):Ebi(h) (binding) | SMRT(h) + Ebi(h) <==> SMRT(h):Ebi(h) (binding) | SUMO2(h) + SMRT(h) --> SMRT(h){sumo2} (sumoylation) | PR A(h) + SMRT(h) <==> PR A(h):SMRT(h) (binding) | SMRT(h) + HDAC4(h) <==> SMRT(h):HDAC4(h) (binding) | SMRT(h) + HDAC4(h) <==> SMRT(h):HDAC4(h) (binding) | SMRT(h) + Sp1(m.s.) <==> SMRT(h):Sp1(m.s.) (binding) | SMRT(h) --/ KLK3(h) (transrepression) | SMRT(h) --/ NKX3-1(h) (transrepression) | SMRT(h) --/ B2M(h) (transrepression) | SMRT(h) + HDAC3(h) + HDAC4(h) <==> SMRT(h):HDAC3(h):HDAC4(h) (binding) | SMRT(h) + AR(h) <==> SMRT(h):AR(h) (binding) | LXR-alpha(h) + SMRT(h) <==> LXR-alpha(h):SMRT(h) (binding) | SMRT(h) + ATP --> SMRT(h){pS2410} + ADP (phosphorylation) | BCL-6(h) + SMRT(h) <==> BCL-6(h):SMRT(h) (binding) | SMRT(h) + HDAC10v1(h) <==> SMRT(h):HDAC10v1(h) (binding) | SMRT(h) + HDAC1(m.s.) <==> SMRT(h):HDAC1(m.s.) (binding) | LXR-beta(h) + SMRT(h) <==> LXR-beta(h):SMRT(h) (binding) | SMRT(h) + NR1B2(h) <==> SMRT(h):NR1B2(h) (binding) | RAR-gamma(h) + SMRT(h) <==> RAR-gamma(h):SMRT(h) (binding) | SMRT(h) + PPARgamma(h) <==> SMRT(h):PPARgamma(h) (binding) | SMRT(h) + ABIN-2(h) <==> SMRT(h):ABIN-2(h) (binding) | SMRT(h) + mu-adaptin2(h) <==> SMRT(h):mu-adaptin2(h) (binding) | SMRT(h) + RanBPM(h) <==> SMRT(h):RanBPM(h) (binding) | SMRT(h) + SHARP(h) <==> SMRT(h):SHARP(h) (binding) | SMRT(h) + RXR-gamma(h) <==> SMRT(h):RXR-gamma(h) (binding) | SMRT(h) + RXR-alpha(h) <==> SMRT(h):RXR-alpha(h) (binding) | NCOR2(h) --> SMRT(h) (expression). | Ebi(h) + HDAC3(h) + SMRT(h) <==> Ebi(h):HDAC3(h):SMRT(h) (binding) | NCOR2(h) --> SMRT(h) (expression). | NCOR2(h) --> SMRTe(h) (expression). | SUNCOR(m) + SMRT-xbb2(h) <==> SUNCOR(m):SMRT-xbb2(h) (binding) | T3R-alpha(c) + SMRT-xbb2(h) <==> T3R-alpha(c):SMRT-xbb2(h) (binding) | Oct-1(h) + SMRT-xbb2(h) <==> Oct-1(h):SMRT-xbb2(h) (binding) | POU2F1(m.s.) + SMRT-xbb2(h) <==> POU2F1(m.s.):SMRT-xbb2(h) (binding) | SMRT-xbb2(h) + RBPJK(m.s.) <==> SMRT-xbb2(h):RBPJK(m.s.) (binding) | SMRT-xbb2(h) + SKIP(h) <==> SMRT-xbb2(h):SKIP(h) (binding) | SMRT-xbb2(h) + CIR-isoform1(h) <==> SMRT-xbb2(h):CIR-isoform1(h) (binding) | NCOR2(h) --> SMRT-xbb2(h) (expression). | NCOR2(h) --> SMRT-TRAC-1(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 149 | Phosphoserine. | Swiss-Prot 53.0 | 152 | Phosphoserine. | Swiss-Prot 53.0 | 215 | Phosphoserine. | Swiss-Prot 53.0 | 553 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 554 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 939 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1253 | Phosphoserine. | Swiss-Prot 53.0 | 1383 | Phosphothreonine. | Swiss-Prot 53.0 | 1576 | Phosphoserine. | Swiss-Prot 53.0 | 1974 | Phosphoserine. | Swiss-Prot 53.0 | 2008 | Phosphoserine. | Swiss-Prot 53.0 | 2049 | Phosphoserine. | Swiss-Prot 53.0 | 2057 | Phosphoserine. | Swiss-Prot 53.0 | 2061 | Phosphoserine. | Swiss-Prot 53.0 | 2197 | Phosphoserine. | Swiss-Prot 53.0 | 2200 | Phosphoserine. | Swiss-Prot 53.0 | 2261 | Phosphoserine. | Swiss-Prot 53.0 | 2455 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 2514 | Phosphoserine. | Swiss-Prot 53.0 | 2516 | Phosphoserine. | Swiss-Prot 53.0 | 1974 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 2261 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 2057 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2061 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2197 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2200 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2416 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2514 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2516 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2410 | Phosphoserine (IKK-alpha) | 15494311 | Phospho.ELM 6.0 | 1383 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 1539 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1576 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1778 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2008 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 2049 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 149 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 152 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 156 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 215 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1017 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1018 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1253 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 123585602 - 123587602 | Agilent_014791 |
chr12 |
Promoter: 123585602 - 123587602 | GSE27584 |
chr12 |
Promoter: 123585602 - 123587602 | GSE27584 |