Entrez Gene

Basic Information
Gene ID	9232
Name	PTTG1
Synonymous	pituitary tumor-transforming 1;PTTG1;pituitary tumor-transforming 1
Definition	ESP1-associated protein 1\|pituitary tumor-transforming gene 1 protein\|securin\|tumor-transforming protein 1
Position	5q35.1
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
securin(h) + p53(h) <==> securin(h):p53(h) (binding)
securin(h) + Separin(h){pS1126} <==> securin(h):Separin(h){pS1126} (binding)
securin(h) + Separin(h) <==> securin(h):Separin(h) (binding)
securin(h) --> protein remnants (degradation)
securin(h) + rae1(h):Nup98(h) <==> securin(h):rae1(h):Nup98(h) (binding)
Fzr1(h) + securin(h) <==> Fzr1(h):securin(h) (binding)
Cdc27(h) + securin(h) <==> Cdc27(h):securin(h) (binding)
securin(h) + PR65-alpha(h) + B56gamma(h) + Separin(h) <==> securin(h):PR65-alpha(h):B56gamma(h):Separin(h) (binding)
securin(h) + Separin(h) <==> securin(h):Separin(h) (binding)
securin(h) + B56alpha(m.s.) <==> securin(h):B56alpha(m.s.) (binding)
securin(h) + n ubiquitin(h) --> securin(h){ub}n (ubiquitination)
PTTG1(h) --> securin(h) (expression).
securin(h) --> protein remnants (degradation)
securin(h) + Separin(h) <==> securin(h):Separin(h) (binding)
securin(h) + ubiquitin(h) --cyclosome(h),E1(m.s.),E2-C(m.s.)--> securin(h){ub} (ubiquitination)
securin(h) + n ubiquitin(h) --cyclosome(h):Fzr1(h),E1(w),Ubc5B(m.s.)--> securin(h){ub}n (ubiquitination)
PTTG1(h) --> securin(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
165	Phosphoserine (by CDC2).		Swiss-Prot 53.0
165	Phosphoserine (CDK1)	10656688;15302935	Phospho.ELM 6.0

Transcription Factors [Top]