Cancer metastasis gene database Home
Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

9138

Name

ARHGEF1

Synonymous

Rho guanine nucleotide exchange factor (GEF) 1;ARHGEF1;Rho guanine nucleotide exchange factor (GEF) 1

Definition

115 kDa guanine nucleotide exchange factor|115-kD protein|Lsc homolog|p115RhoGEF|rho guanine nucleotide exchange factor 1

Position

19q13.13

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

G-alpha-13(mo):GTP + RhoGEF(h) <==> G-alpha-13(mo):GTP:RhoGEF(h) (binding)
ARHGEF1(h) --> RhoGEF(h) (expression).
G-alpha-13(m):GTP --RhoGEF(h)--> G-alpha-13(m):GDP + p (hydrolysis)
RhoA(h):GDP + GTP --RhoGEF(h)--> RhoA(h):GTP + GDP (exchange)
G-alpha-12(m):GTP --RhoGEF(h)--> G-alpha-12(m):GDP + p (hydrolysis)
RhoGEF(h) + ATP --ATR(m.s.)--> RhoGEF(h){pS899} + ADP (phosphorylation)
ARHGEF1(h) --> RhoGEF(h) (expression).

Post Translational Modification   [Top]

There is no record for ARHGEF1

Methylation Profile   [Top]

Chromosome

Location

Source

chr19

Promoter: 47077607 - 47079607Agilent_014791

chr19

Promoter: 47078786 - 47080786Agilent_014791

chr19

Promoter: 47078786 - 47080786GSE27584

chr19

Promoter: 47077607 - 47079607GSE27584

chr19

Promoter: 47077607 - 47079607GSE27584

chr19

Promoter: 47077607 - 47079607Agilent_014791_44K