| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7525 |
Name | YES1 |
Synonymous | YES proto-oncogene 1, Src family tyrosine kinase;YES1;YES proto-oncogene 1, Src family tyrosine kinase |
Definition | YES1 proto-oncogene, Src family tyrosine kinase|Yamaguchi sarcoma oncogene|cellular yes-1 protein|proto-oncogene c-Yes|proto-oncogene tyrosine-protein kinase YES|tyrosine-protein kinase Yes|v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 |
Position | 18p11.31-p11.21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | beta1A-integrin(v.s.) + Yes(h) <==> beta1A-integrin(v.s.):Yes(h) (binding) | beta2-integrin(v.s.) + Yes(h) <==> beta2-integrin(v.s.):Yes(h) (binding) | beta3-integrin(v.s.) + Yes(h) <==> beta3-integrin(v.s.):Yes(h) (binding) | alpha IIb-integrin(h):beta3-integrin(h) + Yes(h) <==> alpha IIb-integrin(h):beta3-integrin(h):Yes(h) (binding) | Yes(h) + ATP --> Yes(h){pY} + ADP (phosphorylation) | YES1(h) --> Yes(h) (expression). | ErbB2(h){pY1222} + Yes(h) <==> ErbB2(h){pY1222}:Yes(h) (binding) | ErbB3-isoform1(h){pY1289} + Yes(h) <==> ErbB3-isoform1(h){pY1289}:Yes(h) (binding) | YES1(h) --> Yes(h) (expression). | YES1(h) --> YES1(h) (expression). | hsa-miR-145 --/ YES1(h) (increase of mRNA decay). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 2 | N-myristoyl glycine (By similarity). | Swiss-Prot 53.0 | 426 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 537 | Phosphotyrosine. | Swiss-Prot 53.0 | 425 | Phosphotyrosine (Yes) | 9794236;16094384 | Phospho.ELM 6.0 | 536 | Phosphotyrosine | 7690925 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr18 |
Promoter: 801827 - 803827 | Agilent_014791 |
chr18 |
Promoter: 801827 - 803827 | GoldenGate_Methylation_Cancer_Panel_I |
chr18 |
Promoter: 801827 - 803827 | GSE27584 |
chr18 |
Promoter: 801827 - 803827 | Agilent_014791_44K |