| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7329 |
Name | UBE2I |
Synonymous | ubiquitin-conjugating enzyme E2I;UBE2I;ubiquitin-conjugating enzyme E2I |
Definition | SUMO-1-protein ligase|SUMO-conjugating enzyme UBC9|SUMO-protein ligase|ubiquitin carrier protein 9|ubiquitin carrier protein I|ubiquitin conjugating enzyme 9|ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)|ubiquitin-conjugating enzyme E2I (homologo |
Position | 16p13.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Ubc9(h) + Aos1(h):SAE2(h):sumo1(h) + ATP --> Ubc9(h){sumo} + Aos1(h):SAE2(h) + AMP + p (sumoylation) | Siah-2(h) + Ubc9(h) <==> Siah-2(h):Ubc9(h) (binding) | Siah1(h) + Ubc9(h) <==> Siah1(h):Ubc9(h) (binding) | RanGAP1(m) + Ubc9(h) <==> RanGAP1(m):Ubc9(h) (binding) | AP-2alpha(h) + Ubc9(h) <==> AP-2alpha(h):Ubc9(h) (binding) | AP-2beta(h) + Ubc9(h) <==> AP-2beta(h):Ubc9(h) (binding) | AP-2gamma(h) + Ubc9(h) <==> AP-2gamma(h):Ubc9(h) (binding) | p73alpha(h) + Ubc9(h) <==> p73alpha(h):Ubc9(h) (binding) | p53(h) + Ubc9(h) <==> p53(h):Ubc9(h) (binding) | Ubc9(h) + sumo1(h) --> Ubc9(h){sumo} (sumoylation) | ER-alpha-L(h) + Ubc9(h) <==> ER-alpha-L(h):Ubc9(h) (binding) | Ubc9(h) + ARIP4(m) <==> Ubc9(h):ARIP4(m) (binding) | Ubc9(h) + DJ-1(h) <==> Ubc9(h):DJ-1(h) (binding) | Ubc9(h) + smad4(h) <==> Ubc9(h):smad4(h) (binding) | proCaspase-2(m.s.) + Ubc9(h) <==> proCaspase-2(m.s.):Ubc9(h) (binding) | Ubc9(h) + Fli-1(h) <==> Ubc9(h):Fli-1(h) (binding) | cystathionine beta-synthase isoform-1(h) + Ubc9(h) <==> cystathionine beta-synthase isoform-1(h):Ubc9(h) (binding) | NIN-isoform1(h) + Ubc9(h) <==> NIN-isoform1(h):Ubc9(h) (binding) | ASK1(h) + Ubc9(h) <==> ASK1(h):Ubc9(h) (binding) | Erm(h) + Ubc9(h) <==> Erm(h):Ubc9(h) (binding) | BLM(m.s.) + Ubc9(h) <==> BLM(m.s.):Ubc9(h) (binding) | MR-isoform1(h) + Ubc9(h) <==> MR-isoform1(h):Ubc9(h) (binding) | Ubc9(h) + IkappaB-alpha(m.s.) <==> Ubc9(h):IkappaB-alpha(m.s.) (binding) | Ubc9(h) + p63alpha(h) <==> Ubc9(h):p63alpha(h) (binding) | AUF1-p37(m.s.) + Ubc9(h) <==> AUF1-p37(m.s.):Ubc9(h) (binding) | Ubc9(h) + RanGAP1(h) <==> Ubc9(h):RanGAP1(h) (binding) | Ubc9(h) + Aos1(h) <==> Ubc9(h):Aos1(h) (binding) | Ubc9(h) + RanBP2(h) <==> Ubc9(h):RanBP2(h) (binding) | Ubc9(h) + sumo1(h) <==> Ubc9(h):sumo1(h) (binding) | Ubc9(h) + sumo3(h) <==> Ubc9(h):sumo3(h) (binding) | Ubc9(h) + SAE2(h) <==> Ubc9(h):SAE2(h) (binding) | DACH1(h) + Ubc9(h) <==> DACH1(h):Ubc9(h) (binding) | EDR1(h) + Ubc9(h) <==> EDR1(h):Ubc9(h) (binding) | hnRNP-C(h) + Ubc9(h) <==> hnRNP-C(h):Ubc9(h) (binding) | hnRNPK(h) + Ubc9(h) <==> hnRNPK(h):Ubc9(h) (binding) | SATB1(h) + Ubc9(h) <==> SATB1(h):Ubc9(h) (binding) | Ubc9(h) + RIP2(h) <==> Ubc9(h):RIP2(h) (binding) | Ubc9(h) + PIAS2(h) <==> Ubc9(h):PIAS2(h) (binding) | Ubc9(h) + HRS(h) <==> Ubc9(h):HRS(h) (binding) | Ubc9(h) + DREF(h) <==> Ubc9(h):DREF(h) (binding) | Ubc9(h) + LMP(h) <==> Ubc9(h):LMP(h) (binding) | Ubc9(h) + znf646(h) <==> Ubc9(h):znf646(h) (binding) | Ubc9(h) + Ikaros(h) <==> Ubc9(h):Ikaros(h) (binding) | Ubc9(h) + Aiolos(h) <==> Ubc9(h):Aiolos(h) (binding) | Ubc9(h) + nudcd3(h) <==> Ubc9(h):nudcd3(h) (binding) | Ubc9(h) + TRIM29(h) <==> Ubc9(h):TRIM29(h) (binding) | Ubc9(h) + Rad54B(h) <==> Ubc9(h):Rad54B(h) (binding) | Ubc9(h) + ZN451(h) <==> Ubc9(h):ZN451(h) (binding) | Ubc9(h) + mapk1ip1l(h) <==> Ubc9(h):mapk1ip1l(h) (binding) | Ubc9(h) + chmp4b(h) <==> Ubc9(h):chmp4b(h) (binding) | Ubc9(h) + c18orf25(h) <==> Ubc9(h):c18orf25(h) (binding) | REVERB-beta(h) + Ubc9(h) <==> REVERB-beta(h):Ubc9(h) (binding) | RORbeta(h) + Ubc9(h) <==> RORbeta(h):Ubc9(h) (binding) | LXR-beta(h) + Ubc9(h) <==> LXR-beta(h):Ubc9(h) (binding) | Ubc9(h) + HNF-4alpha(h) <==> Ubc9(h):HNF-4alpha(h) (binding) | Ubc9(h) + RG4(h) <==> Ubc9(h):RG4(h) (binding) | Ubc9(h) + Sox4(h) <==> Ubc9(h):Sox4(h) (binding) | IkappaB-alpha(h) + Ubc9(h){sumo} + ATP --> IkappaB-alpha(h){sumo} + Ubc9(h) + AMP + p (conjugation; stabilization) | UBE2I(h) --> Ubc9(h) (expression). | RanGAP1(m) + Ubc9(h){sumo} + ADP --> RanGAP1(m){sumo} + Ubc9(h) + p + AMP (conjugation) | Ca --> Ubc9(h) (increase of abundance) | p53(v.s.) + sumo1(v.s.) --Aos1(h):SAE2(h),Ubc9(h),PIAS1(h)--> p53(v.s.){sumo} (sumoylation) | p53(h) + sumo1(v.s.) --Ubc9(h)--> p53(h){sumoK386} (sumoylation) | topoisomerase-II-beta-isoform2(h) + Ubc9(h) <==> topoisomerase-II-beta-isoform2(h):Ubc9(h) (binding) | topoisomerase-II-alpha(h) + Ubc9(h) <==> topoisomerase-II-alpha(h):Ubc9(h) (binding) | topoisomerase-II-alpha-isoform1(h) + Ubc9(h) <==> topoisomerase-II-alpha-isoform1(h):Ubc9(h) (binding) | topoisomerase-II-beta(h) + Ubc9(h) <==> topoisomerase-II-beta(h):Ubc9(h) (binding) | topoisomerase-II(h) + Ubc9(h) <==> topoisomerase-II(h):Ubc9(h) (binding) | Ubc9(h) + Daxx(h) <==> Ubc9(h):Daxx(h) (binding) | C/EBPalpha(m) + Ubc9(h) <==> C/EBPalpha(m):Ubc9(h) (binding) | Ubc9(h) + c-Ets-1(m) <==> Ubc9(h):c-Ets-1(m) (binding) | Ubc9(h) + OZF(h) <==> Ubc9(h):OZF(h) (binding) | Ubc9(h) + n sumo1(m.s.) --Aos1(m.s.):SAE2(m.s.)--> Ubc9(h){sumo(n)} (sumoylation) | c-Myb-isoform1(h) + Ubc9(h) <==> c-Myb-isoform1(h):Ubc9(h) (binding) | PIAS1(m.s.) + Ubc9(h) <==> PIAS1(m.s.):Ubc9(h) (binding) | PIAS2-alpha(m.s.) + Ubc9(h) <==> PIAS2-alpha(m.s.):Ubc9(h) (binding) | RanGAP1(h){sumoK524} + Ubc9(h) + RanBP2(h) <==> RanGAP1(h){sumoK524}:Ubc9(h):RanBP2(h) (binding) | RanBP2(h) + Ubc9(h) <==> RanBP2(h):Ubc9(h) (binding) | NIN-isoform1(h) + Ubc9(h) <==> NIN-isoform1(h):Ubc9(h) (binding) | ASK1(m.s.) + Ubc9(h) <==> ASK1(m.s.):Ubc9(h) (binding) | BLM(h) + Ubc9(h) <==> BLM(h):Ubc9(h) (binding) | Ubc9(h) + sumo1(h) --Aos1(h):SAE2(h)--> Ubc9(h){sumoC93} (sumoylation; conjugation) | Ubc9(h) + sumo1(h) --Aos1(h):SAE2(h)--> Ubc9(h){sumo} (sumoylation; conjugation) | Ubc9(h) + SUMO2(h) --Aos1(h):SAE2(h)--> Ubc9(h){sumo2} (sumoylation; conjugation) | Ubc9(h) + sumo3(h) --Aos1(h):SAE2(h)--> Ubc9(h){sumo3} (sumoylation; conjugation) | p63alpha(h) + Ubc9(h) <==> p63alpha(h):Ubc9(h) (binding) | COUP-TF1(h) + Ubc9(h) <==> COUP-TF1(h):Ubc9(h) (binding) | COUP-TF2(m.s.) + Ubc9(h) <==> COUP-TF2(m.s.):Ubc9(h) (binding) | Ubc9(h) + SF-1(m.s.) <==> Ubc9(h):SF-1(m.s.) (binding) | AUF1-p37(m.s.) + Ubc9(h) <==> AUF1-p37(m.s.):Ubc9(h) (binding) | AUF1-p40(m.s.) + Ubc9(h) <==> AUF1-p40(m.s.):Ubc9(h) (binding) | AUF1-p42(m.s.) + Ubc9(h) <==> AUF1-p42(m.s.):Ubc9(h) (binding) | AUF1-p45(m.s.) + Ubc9(h) <==> AUF1-p45(m.s.):Ubc9(h) (binding) | Ubc9(h) + TIF2(m) <==> Ubc9(h):TIF2(m) (binding) | Ubc9(h) + ZAC-1b(m) <==> Ubc9(h):ZAC-1b(m) (binding) | p53-isoform1(h) + Ubc9(h) <==> p53-isoform1(h):Ubc9(h) (binding) | Ubc9(h) + Sox4(h) <==> Ubc9(h):Sox4(h) (binding) | UBE2I(h) --> Ubc9(h) (expression). | mef2d(h) + sumo3(h) --Ubc9(h),Aos1(h):SAE2(h)--> mef2d(h){sumo3K439} (sumoylation) | Daxx(h) + 2 sumo1(m.s.) --Ubc9(h)--> Daxx(h){sumoK630}{sumoK631} (sumoylation) | c-Ets-1(m) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> c-Ets-1(m){sumoK15} (sumoylation) | Daxx(m.s.) + sumo1(m.s.) --Ubc9(h)--> Daxx(m.s.){sumoK630}{sumoK631} (sumoylation) | TopoI(h) + sumo1(m.s.) --Aos1(m.s.):SAE2(m.s.),Ubc9(h)--> TopoI(h){sumoK117} (sumoylation) | c-Myb-isoform1(h) + 2 sumo1(h) --Aos1(mo):SAE2(mo),Ubc9(h)--> c-Myb-isoform1(h){sumoK503}{sumoK527} (sumoylation) | C/EBPalpha(m) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h)--> C/EBPalpha(m){sumoK159} (sumoylation) | AR-isoform1(h) + 2 sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h),PIAS1(m.s.)--> AR-isoform1(h){sumoK386}{sumoK520} (sumoylation) | AR-isoform1(h) + 2 sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h),PIAS2-alpha(m.s.)--> AR-isoform1(h){sumoK386}{sumoK520} (sumoylation) | IKK-gamma(h) + sumo1(h) --PIASy(h),Ubc9(h)--> IKK-gamma(h){sumo} (sumoylation) | Sox2(m) + sumo1(h) --Ubc9(h)--> Sox2(m){sumoK247} (sumoylation) | POU5F1-xbb1(m) + sumo1(h) --Ubc9(h)--> POU5F1-xbb1(m){sumoK118} (sumoylation) | IKK-gamma(h) + 2 sumo1(h) --Ubc9(h)--> IKK-gamma(h){sumoK277}{sumoK309} (sumoylation) | SP100(m.s.) + sumo1(m.s.) --Ubc9(h),Aos1(h):SAE2(h)--> SP100(m.s.){sumo} (sumoylation) | SP100(m.s.) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h),RanBP2(h)--> SP100(m.s.){sumo} (sumoylation) | SP100(m.s.) + SUMO2(h) --Aos1(h):SAE2(h),Ubc9(h)--> SP100(m.s.){sumo2} (sumoylation) | SP100(m.s.) + SUMO2(h) --Aos1(h):SAE2(h),Ubc9(h),RanBP2(h)--> SP100(m.s.){sumo2} (sumoylation) | PML(m.s.) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h)--> PML(m.s.){sumo} (sumoylation) | PML(m.s.) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h),RanBP2(h)--> PML(m.s.){sumo} (sumoylation) | PML(m.s.) + SUMO2(h) --Aos1(h):SAE2(h),Ubc9(h)--> PML(m.s.){sumo2} (sumoylation) | PML(m.s.) + SUMO2(h) --Aos1(h):SAE2(h),Ubc9(h),RanBP2(h)--> PML(m.s.){sumo2} (sumoylation) | Sox9(m.s.) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h),PIAS1(m.s.)--> Sox9(m.s.){sumo} (sumoylation) | Sox9(m.s.) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h),PIAS3(m.s.)--> Sox9(m.s.){sumo} (sumoylation) | Sox9(m.s.) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h),PIAS2-alpha(m.s.)--> Sox9(m.s.){sumo} (sumoylation) | Sox9(m.s.) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h),PIAS2-beta(m.s.)--> Sox9(m.s.){sumo} (sumoylation) | Sox9(m.s.) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(h)--> Sox9(m.s.){sumo} (sumoylation) | RanGAP1(h) + sumo1(h) --Ubc9(h)--> RanGAP1(h){sumo} (sumoylation) | cystathionine beta-synthase isoform-1(h) + sumo1(h) --Aos1(h):SAE2(h),PIAS1(m.s.),Ubc9(h)--> cystathionine beta-synthase isoform-1(h){sumoK211} (sumoylation) | NIN-isoform1(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> NIN-isoform1(h){sumo} (sumoylation) | NSE2(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> NSE2(h){sumo} (sumoylation) | ER81(m.s.) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> ER81(m.s.){sumo} (sumoylation) | TRAX(m.s.) + sumo1(h) --Aos1(h):SAE2(h),NSE2(h),Ubc9(h)--> TRAX(m.s.){sumo} (sumoylation) | DJ-1(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> DJ-1(h){sumo} (sumoylation) | TAFII20(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> TAFII20(h){sumoK19} (sumoylation) | TBP(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> TBP(h){sumo} (sumoylation) | TAF(II)100-L(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> TAF(II)100-L(h){sumoK14} (sumoylation) | TAF(II)250-isoform1(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> TAF(II)250-isoform1(h){sumo} (sumoylation) | TAF2J(h):TAF(II)31(h):TBP(h):TAF(II)70(h):TAF(II)100(h):TAF(II)250(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> TAF2J(h){sumo}:TAF(II)31(h):TBP(h):TAF(II)70(h):TAF(II)100(h){sumo}:TAF(II)250(h) (sumoylation) | p53(m.s.) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h),LUN-isoform1(h)--> p53(m.s.){sumo} (sumoylation) | p53-isoform1(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> p53-isoform1(h){sumoK386} (sumoylation) | RanGAP1(h) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> RanGAP1(h){sumo} (sumoylation) | RanGAP1(m) + sumo1(h) --Aos1(h):SAE2(h),Ubc9(h)--> RanGAP1(m){sumo} (sumoylation) | RanGAP1(m) + SUMO2(h) --Aos1(h):SAE2(h),Ubc9(h)--> RanGAP1(m){sumo2} (sumoylation) | RanGAP1(m) + sumo3(h) --Aos1(h):SAE2(h),Ubc9(h)--> RanGAP1(m){sumo3} (sumoylation) | mdm2-isoform1(h) + sumo1(h) --Aos1(m.s.):SAE2(m.s.),Ubc9(h),RanBP2(m.s.)--> mdm2-isoform1(h){sumo} (sumoylation) | mdm2-isoform1(h) + sumo1(h) --Aos1(m.s.):SAE2(m.s.),Ubc9(h),PIAS2-beta(m.s.)--> mdm2-isoform1(h){sumo} (sumoylation) |
|---|
Post Translational Modification [Top] | |||
There is no record for UBE2I | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr16 |
Promoter: 1298139 - 1300139 | Agilent_014791 |
chr16 |
Promoter: 1297862 - 1299862 | Agilent_014791 |
chr16 |
Promoter: 1297681 - 1299681 | Agilent_014791 |
chr16 |
Promoter: 1298139 - 1300139 | GSE27584 |
chr16 |
Promoter: 1297862 - 1299862 | GSE27584 |
chr16 |
Promoter: 1297681 - 1299681 | GSE27584 |
chr16 |
Promoter: 1298139 - 1300139 | GSE27584 |
chr16 |
Promoter: 1298139 - 1300139 | Agilent_014791_44K |