| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7083 |
Name | TK1 |
Synonymous | thymidine kinase 1, soluble;TK1;thymidine kinase 1, soluble |
Definition | thymidine kinase 1 soluble isoform|thymidine kinase, cytosolic|thymidine kinase-1 |
Position | 17q23.2-q25.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | p21Cip1(h) + TK1(h) <==> p21Cip1(h):TK1(h) (binding) | TK1(h) --> Cdk2(m):p21Cip1(h) (decrease of binding) | TK1(h) + n ubiquitin(h) --> TK1(h){ub}n (ubiquitination) | TK1(h) + Fzr1(m.s.) <==> TK1(h):Fzr1(m.s.) (binding) | TK1(h) + Cdc20(m.s.) <==> TK1(h):Cdc20(m.s.) (binding) | tk1(h) --> TK1(h) (expression). | p21Cip1(h) + TK1(h) <==> p21Cip1(h):TK1(h) (binding) | TK1(h) + CRMP1(h) <==> TK1(h):CRMP1(h) (binding) | TK1(h) + GAPD(h) <==> TK1(h):GAPD(h) (binding) | TK1(h) + Grg-1(h) <==> TK1(h):Grg-1(h) (binding) | TK1(h) + p53(h) <==> TK1(h):p53(h) (binding) | TK1(h) + RG4(h) <==> TK1(h):RG4(h) (binding) | TK1(h) + RIF1(h) <==> TK1(h):RIF1(h) (binding) | TK1(h) + APLP1(h) <==> TK1(h):APLP1(h) (binding) | TK1(h) + TUBB2(h) <==> TK1(h):TUBB2(h) (binding) | TK1(h) + ESET(h) <==> TK1(h):ESET(h) (binding) | TK1(h) + NC2alpha(h) <==> TK1(h):NC2alpha(h) (binding) | TK1(h) + COPS6(h) <==> TK1(h):COPS6(h) (binding) | TK1(h) + c14orf1(h) <==> TK1(h):c14orf1(h) (binding) | TK1(h) + c7orf64(h) <==> TK1(h):c7orf64(h) (binding) | tk1(h) --> TK1(h) (expression). | IKK-alpha(h) --> TK1(h) (increase of abundance) | E2F-1(h) --> TK1(h) (increase of abundance) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 13 | Phosphoserine. | Swiss-Prot 53.0 | 231 | Phosphoserine. | Swiss-Prot 53.0 | 13 | Phosphoserine (CDK1;CDK2) | 9575153 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 73694226 - 73696226 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 73694226 - 73696226 | GSE27584 |