| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 7082 |
Name | TJP1 |
Synonymous | tight junction protein 1;TJP1;tight junction protein 1 |
Definition | tight junction protein ZO-1|zona occludens 1|zonula occludens 1 protein |
Position | 15q13 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | zo-1(h) + ATP --> zo-1(h){pY} + ADP (phosphorylation) | zo-1(h) + gja1(h) <==> zo-1(h):gja1(h) (binding) | SS3R(h) + MUPP-1(h) + zo-1(h) + tjp2(h) + MAGI-3(h) + MAGUKp55(h) + Hsp70(h) + PIST(h) <==> SS3R(h):MUPP-1(h):zo-1(h):tjp2(h):MAGI-3(h):MAGUKp55(h):Hsp70(h):PIST(h) (binding) | TJP1(h) --> zo-1(h) (expression). | IGF-1(m.s.) --> zo-1(h) (increase of abundance) | TJP1(h) --> zo-1(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 166 | Phosphoserine. | Swiss-Prot 53.0 | 168 | Phosphoserine. | Swiss-Prot 53.0 | 175 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 275 | Phosphoserine. | Swiss-Prot 53.0 | 277 | Phosphoserine. | Swiss-Prot 53.0 | 280 | Phosphoserine. | Swiss-Prot 53.0 | 284 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 297 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 300 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 337 | Phosphoserine. | Swiss-Prot 53.0 | 402 | Phosphoserine. | Swiss-Prot 53.0 | 617 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 868 | Phosphothreonine. | Swiss-Prot 53.0 | 1366 | Phosphoserine. | Swiss-Prot 53.0 | 588 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 1435 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr15 |
Promoter: 27901498 - 27903498 | Agilent_014791 |
chr15 |
Promoter: 27901498 - 27903498 | GoldenGate_Methylation_Cancer_Panel_I |
chr15 |
Promoter: 27901498 - 27903498 | GoldenGate_Methylation_Cancer_Panel_I |
chr15 |
Promoter: 27901498 - 27903498 | GSE27584 |
chr15 |
Promoter: 27901498 - 27903498 | GSE27584 |