Entrez Gene

Basic Information
Gene ID	6868
Name	ADAM17
Synonymous	ADAM metallopeptidase domain 17;ADAM17;ADAM metallopeptidase domain 17
Definition	ADAM metallopeptidase domain 18\|TNF-alpha convertase\|TNF-alpha converting enzyme\|disintegrin and metalloproteinase domain-containing protein 17\|snake venom-like protease\|tumor necrosis factor, alpha, converting enzyme
Position	2p25
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
TACE(h) + Eve-1c(h) <==> TACE(h):Eve-1c(h) (binding)
TACE(h) + Eve-1d(h) <==> TACE(h):Eve-1d(h) (binding)
TACE(h) --> TACE-p100(h) + protein remnants (cleavage)
TACE(h) --> EGFR(h){pY} (increase of phosphorylation)
TACE(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation)
TACE(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation)
TACE(h) --> AKT-1(h){pS473} (increase of phosphorylation)
ADAM17(h) --> TACE(h) (expression).
ADAM17(h) --> TACE(h) (expression).
APP770(h) --TACE(h)--> sAPP770alpha(h) + APP-C83(h) (cleavage)
AR-isoform1(h) --TACE(h)--> AR-isoform1-p20(h) + protein remnants (cleavage)
AR-isoform1(h) --TACE(h)--> AR-isoform1-p17(h) + protein remnants (cleavage)
AR-isoform1(h) --TACE(h)--> AR-isoform1-p12(h) + protein remnants (cleavage)
HB-EGF(h) --TACE(h)--> HB-EGF-p17(h) + protein remnants (cleavage)
HB-EGF(h) --TACE(h)--> HB-EGF-p16(h) + protein remnants (cleavage)

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
103	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
157	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
174	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
264	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
379	Phosphotyrosine.		Swiss-Prot 53.0
382	Phosphoserine.		Swiss-Prot 53.0
452	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
498	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
539	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
551	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
594	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
735	Phosphothreonine (by MAPK).		Swiss-Prot 53.0
791	Phosphoserine.		Swiss-Prot 53.0
819	Phosphoserine.		Swiss-Prot 53.0
735	Phosphothreonine (MAPK3)	12058067	Phospho.ELM 6.0
819	Phosphoserine (Lck)	12621058;15743820	Phospho.ELM 6.0
791	Phosphoserine	12621058;17081983	Phospho.ELM 6.0
379	Phosphotyrosine	17081983	Phospho.ELM 6.0
382	Phosphoserine	17081983	Phospho.ELM 6.0

Transcription Factors [Top]