| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 6490 |
Name | PMEL |
Synonymous | premelanosome protein;PMEL;premelanosome protein |
Definition | melanocyte protein PMEL|melanocyte protein Pmel 17|melanocyte protein mel 17|melanocytes lineage-specific antigen GP100|melanoma-associated ME20 antigen|melanosomal matrix protein17|silver locus protein homolog|silver, mouse, homolog of |
Position | 12q13-q14 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | SILV(h) --> PMEL17-isoform1(h) (expression). | MLANA(h) + PMEL17(h) <==> MLANA(h):PMEL17(h) (binding) | MLANA(h) + PMEL17(h) <==> MLANA(h):PMEL17(h) (binding) | PMEL17(h) + gamma-adaptin 1(h) <==> PMEL17(h):gamma-adaptin 1(h) (binding) | PMEL17(h) + alpha-adaptin(h) <==> PMEL17(h):alpha-adaptin(h) (binding) | PMEL17(h) --Rab7(m.s.)--> PMEL17-p29(h) + PMEL17-p32(h) + protein remnants (cleavage) | SILV(h) --> PMEL17(h) (expression). | NCKX5(h) --> PMEL17(h) (increase of abundance) | MITF(h) --> PMEL17(h) (increase of abundance) | PMEL17-isoform2(h) --> melanin (increase of abundance) | SILV(h) --> PMEL17-isoform2(h) (expression). | SILV(h) --> PMEL17-isoform3(h) (expression). | SILV(h) --> PMEL17-isoform4(h) (expression). | SILV(h) --> PMEL17-isoform5(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 81 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 106 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 111 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 321 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 568 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for PMEL | ||