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Cancer metastasis database
General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction

Basic Information

Gene ID

6256

Name

RXRA

Synonymous

retinoid X receptor, alpha;RXRA;retinoid X receptor, alpha

Definition

nuclear receptor subfamily 2 group B member 1|retinoic acid receptor RXR-alpha|retinoid X nuclear receptor alpha

Position

9q34.3

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

RXR-alpha(h) --> apoAI(h) (DNA binding).
RXR-alpha(h) --> RARB(h) (DNA binding).
RXR-alpha(h) --> Mo-MuLV(MOMLV) (DNA binding).
RXR-alpha(h) --> ADH3(h) (DNA binding).
RXR-alpha(h) --> CT/CGRP(r) (DNA binding).
RXR-alpha(h) --> Spp1(m) (DNA binding).
COUP-TF2(h) + RXR-alpha(h) <==> COUP-TF2(h):RXR-alpha(h) (binding).
COUP(r) + RXR-alpha(h) <==> COUP(r):RXR-alpha(h) (binding).
COUP-TF1(c) + RXR-alpha(h) <==> COUP-TF1(c):RXR-alpha(h) (binding).
COUP-TF1(h) + RXR-alpha(h) <==> COUP-TF1(h):RXR-alpha(h) (binding).
EcR(d) + RXR-alpha(h) <==> EcR(d):RXR-alpha(h) (binding).
PPARalpha(m) + RXR-alpha(h) <==> PPARalpha(m):RXR-alpha(h) (binding).
NR1B1-isoform1(h) + RXR-alpha(h) <==> NR1B1-isoform1(h):RXR-alpha(h) (binding).
RAR-gamma(h) + RXR-alpha(h) <==> RAR-gamma(h):RXR-alpha(h) (binding)
RXR-alpha(h) + NR1B2(h) <==> RXR-alpha(h):NR1B2(h) (binding).
T3R-alpha(r) + RXR-alpha(h) <==> T3R-alpha(r):RXR-alpha(h) (binding).
T3R-beta1(h) + RXR-alpha(h) <==> T3R-beta1(h):RXR-alpha(h) (binding).
T3R-beta(r) + RXR-alpha(h) <==> T3R-beta(r):RXR-alpha(h) (binding).
VDR(r) + RXR-alpha(h) <==> VDR(r):RXR-alpha(h) (binding).
VDR(m) + RXR-alpha(h) <==> VDR(m):RXR-alpha(h) (binding).
VDR(c) + RXR-alpha(h) <==> VDR(c):RXR-alpha(h) (binding).
VDR(h) + RXR-alpha(h) <==> VDR(h):RXR-alpha(h) (binding)
COUP-TF1(m) + RXR-alpha(h) <==> COUP-TF1(m):RXR-alpha(h) (binding).
T3R-alpha1(h) + RXR-alpha(h) <==> T3R-alpha1(h):RXR-alpha(h) (binding).
T3R-alpha2(m) + RXR-alpha(h) <==> T3R-alpha2(m):RXR-alpha(h) (binding).
NR1B1(m) + RXR-alpha(h) <==> NR1B1(m):RXR-alpha(h) (binding).
RAR-gamma(m) + RXR-alpha(h) <==> RAR-gamma(m):RXR-alpha(h) (binding).
RAR-gamma1(h) + RXR-alpha(h) <==> RAR-gamma1(h):RXR-alpha(h) (binding).
VDR(pg) + RXR-alpha(h) <==> VDR(pg):RXR-alpha(h) (binding).
T3R-alpha(c) + RXR-alpha(h) <==> T3R-alpha(c):RXR-alpha(h) (binding).
NR1B1(x) + RXR-alpha(h) <==> NR1B1(x):RXR-alpha(h) (binding).
TIF1(m) + RXR-alpha(h) <==> TIF1(m):RXR-alpha(h) (binding).
PPARgamma1(m) + RXR-alpha(h) <==> PPARgamma1(m):RXR-alpha(h) (binding).
SHP(h) + RXR-alpha(h) <==> SHP(h):RXR-alpha(h) (binding).
LXR-alpha(h) + RXR-alpha(h) <==> LXR-alpha(h):RXR-alpha(h) (binding)
LXR-alpha(m) + RXR-alpha(h) <==> LXR-alpha(m):RXR-alpha(h) (binding).
LXR-beta(r) + RXR-alpha(h) <==> LXR-beta(r):RXR-alpha(h) (binding).
LXR-beta(m) + RXR-alpha(h) <==> LXR-beta(m):RXR-alpha(h) (binding).
FXR(r) + RXR-alpha(h) <==> FXR(r):RXR-alpha(h) (binding).
FXR-isoform4(h) + RXR-alpha(h) <==> FXR-isoform4(h):RXR-alpha(h) (binding).
SKIP(h) + RXR-alpha(h) <==> SKIP(h):RXR-alpha(h) (binding).
PXR-isoform1(m) + RXR-alpha(h) <==> PXR-isoform1(m):RXR-alpha(h) (binding).
PXR-isoform2(m) + RXR-alpha(h) <==> PXR-isoform2(m):RXR-alpha(h) (binding).
SRC3(h) + RXR-alpha(h) <==> SRC3(h):RXR-alpha(h) (binding).
FOR1(x) + RXR-alpha(h) <==> FOR1(x):RXR-alpha(h) (binding).
FOR2(x) + RXR-alpha(h) <==> FOR2(x):RXR-alpha(h) (binding).
PPARgamma(v.s.) + RXR-alpha(h) <==> PPARgamma(v.s.):RXR-alpha(h) (binding)
PPARdelta(h) + RXR-alpha(h) <==> PPARdelta(h):RXR-alpha(h) (binding)
NR1B2-isoform2(h) + RXR-alpha(h) <==> NR1B2-isoform2(h):RXR-alpha(h) (binding).
RXR-alpha(h) + PPARgamma1(h) <==> RXR-alpha(h):PPARgamma1(h) (binding).
RXR-alpha(h) + PPARgamma2(h) <==> RXR-alpha(h):PPARgamma2(h) (binding).
PPARdelta(m) + RXR-alpha(h) <==> PPARdelta(m):RXR-alpha(h) (binding).
NR1B1(h) + RXR-alpha(h) <==> NR1B1(h):RXR-alpha(h) (interaction; binding)
FXR-isoform3(h) + RXR-alpha(h) <==> FXR-isoform3(h):RXR-alpha(h) (binding).
CAR(r) + RXR-alpha(h) <==> CAR(r):RXR-alpha(h) (binding).
RXR-alpha(h) + ATP --JNK1(h){p}--> RXR-alpha(h){p} + ADP (phosphorylation)
RXR-alpha(h) + ATP --MKK4(h){p}--> RXR-alpha(h){p} + ADP (phosphorylation)
2 RXR-alpha(h) <==> (RXR-alpha(h))2 (binding).
NR1B2(m) + RXR-alpha(h) <==> NR1B2(m):RXR-alpha(h) (binding).
FXR(m) + RXR-alpha(h) <==> FXR(m):RXR-alpha(h) (binding).
PPARgamma(h) + RXR-alpha(h) <==> PPARgamma(h):RXR-alpha(h) (binding).
tuberin(h) + RXR-alpha(h) <==> tuberin(h):RXR-alpha(h) (binding)
RXR-alpha(h) + beta-catenin(h) <==> beta-catenin(h):RXR-alpha(h) (binding)
GADD45-alpha(h) + RXR-alpha(h) <==> GADD45-alpha(h):RXR-alpha(h) (binding)
GADD45-beta(m) + RXR-alpha(h) <==> GADD45-beta(m):RXR-alpha(h) (binding)
GADD45-gamma(h) + RXR-alpha(h) <==> GADD45-gamma(h):RXR-alpha(h) (binding)
RXR-alpha(h) + PNRC2(h) <==> RXR-alpha(h):PNRC2(h) (binding)
PGC-1(h) + RXR-alpha(h) <==> PGC-1(h):RXR-alpha(h) (binding)
TFIIB(h) + RXR-alpha(h) <==> TFIIB(h):RXR-alpha(h) (binding)
RXR-alpha(h) --> VDR(h) (binding)
HR(r) + RXR-alpha(h) <==> HR(r):RXR-alpha(h) (binding)
RXR-alpha(h) + ER-beta(r) <==> RXR-alpha(h):ER-beta(r) (binding)
RXR-alpha(h) + IGFBP-3(h) <==> RXR-alpha(h):IGFBP-3(h) (binding)
GR(h) + RXR-alpha(h) <==> GR(h):RXR-alpha(h) (binding)
RXR-alpha(h) + sumo1(h) --> RXR-alpha(h){sumo} (sumoylation)
SUSP1(h) + RXR-alpha(h) <==> SUSP1(h):RXR-alpha(h) (binding)
RXR-alpha(h) --> CD1D(h) (DNA binding).
RXR-alpha(h) --> SOX3(h) (DNA binding).
RXR-alpha(h) + ATSV(h) <==> RXR-alpha(h):ATSV(h) (binding)
SRC-1(h) + RXR-alpha(h) <==> SRC-1(h):RXR-alpha(h) (binding)
SMRT(h) + RXR-alpha(h) <==> SMRT(h):RXR-alpha(h) (binding)
T3R-alpha(h) + RXR-alpha(h) <==> T3R-alpha(h):RXR-alpha(h) (binding)
T3R-beta(h) + RXR-alpha(h) <==> T3R-beta(h):RXR-alpha(h) (binding)
NURR1(h) + RXR-alpha(h) <==> NURR1(h):RXR-alpha(h) (binding)
LXR-beta(h) + RXR-alpha(h) <==> LXR-beta(h):RXR-alpha(h) (binding)
PXR(h) + RXR-alpha(h) <==> PXR(h):RXR-alpha(h) (binding)
RXR-alpha(h) + 2 ATP --> RXR-alpha(h){pT82}{pS260} + 2 ADP (phosphorylation)
RXR-alpha(h) --> RXR-alpha-p44(h) + protein remnants (degradation)
RXR-alpha(h) + ATP --> RXR-alpha(h){pT82} + ADP (phosphorylation)
RXR-alpha(h) --> Rbp2(r) (DNA binding).
RXR-alpha(h) --> SULT2A1(h) (DNA binding).
RXR-alpha(h) --> GNRH2(h) (DNA binding).
Ubiquilin-4(h) + RXR-alpha(h) <==> Ubiquilin-4(h):RXR-alpha(h) (binding)
tmprss3(h) + RXR-alpha(h) <==> tmprss3(h):RXR-alpha(h) (binding)
RXR-alpha(h) --> IER3(h) (DNA binding; transactivation).
RXRA(h) --> RXR-alpha(h) (expression).
TFIIB(h) --> RXR-alpha(h) (binding)
RXR-alpha(h) --> Bglap(r) (DNA binding).
RXR-alpha(h) --> Ov(c) (DNA binding).
RXR-alpha(h) --> LYS(c) (DNA binding; transregulation).
RXR-alpha(h) --> RARG(h) (DNA binding).
RXR-alpha(h) --> Rbp2(r) (DNA binding).
RXR-alpha(h) --> CRBPI(r) (DNA binding).
RXR-alpha(h) --> HBV enhancer(HBV) (DNA binding).
RXR-alpha(h) --> EGFR(h) (DNA binding).
RXR-alpha(h) --> Acox1(r) (DNA binding).
RXR-alpha(h) --> 3KAT(r) (DNA binding).
RXR-alpha(h) --> RSV(RSV) (DNA binding; transregulation).
RXR-alpha(h) --> ACADM(h) (DNA binding).
RXR-alpha(h) --> RVL-3(m) (DNA binding).
RXR-alpha(h) --> AFP(r) (DNA binding; transregulation).
RXR-alpha(h) --> H1f0(m) (DNA binding; transregulation).
RXR-alpha(h) --> MyoD1(m) (DNA binding; transregulation).
RXR-alpha(h) --> Cyp7a1(r) (DNA binding).
RXR-alpha(h) --> hsp27(d) (DNA binding).
RXR-alpha(h) --> PTH(c) (DNA binding; transregulation).
RXR-alpha(h) --> PTHR1(r) (DNA binding).
RXR-alpha(h) --> CAII(c) (DNA binding; transregulation).
RXR-alpha(h) --> CDKN1A(h) (DNA binding; transregulation).
RXR-alpha(h) --> ACACA(c) (DNA binding).
RXR-alpha(h) --> Fos(m) (DNA binding).
RXR-alpha(h) --> S100G(h) (DNA binding).
RXR-alpha(h) --> Pthr1(m) (DNA binding).
RXR-alpha(h) --> PLTP(h) (DNA binding).
RXR-alpha(h) --> AQP7(m) (DNA binding; transactivation).
RXR-alpha(h) --> RBP4(h) (DNA binding; transactivation).
ASC-2(r) + RXR-alpha(h) <==> ASC-2(r):RXR-alpha(h) (binding)
ASC-2(h) + RXR-alpha(h) <==> ASC-2(h):RXR-alpha(h) (binding)
RXR-alpha(h) + VDR(h) <==> RXR-alpha(h):VDR(h) (binding)
GT198(r) + RXR-alpha(h) <==> GT198(r):RXR-alpha(h) (binding)
RXR-alpha(h) + ER-alpha-L(h) <==> RXR-alpha(h):ER-alpha-L(h) (binding)
ER(m.s.) + RXR-alpha(h) <==> ER(m.s.):RXR-alpha(h) (binding)
RXR-alpha(h) + ER-beta(m) <==> RXR-alpha(h):ER-beta(m) (binding)
T3R-beta(h) + RXR-alpha(h) <==> T3R-beta(h):RXR-alpha(h) (binding)
RXR-alpha(h) + DRIP205-isoform1(h) <==> RXR-alpha(h):DRIP205-isoform1(h) (binding)
RXR-alpha(h) + DRIP100(h) <==> RXR-alpha(h):DRIP100(h) (binding)
RXR-alpha(h) + ARA70-alpha(h) <==> RXR-alpha(h):ARA70-alpha(h) (binding)
RXR-alpha(h) + beta3-endonexin(h) <==> RXR-alpha(h):beta3-endonexin(h) (binding)
ASC-1(h) + RXR-alpha(h) <==> ASC-1(h):RXR-alpha(h) (binding)
SRC-1A(h) + RXR-alpha(h) <==> SRC-1A(h):RXR-alpha(h) (binding)
SRC-1A(h) + RXR-alpha(h) + ASC-1(h) + CBP(m.s.) <==> SRC-1A(h):CBP(m.s.):RXR-alpha(h):ASC-1(h) (binding)
IkappaB-beta(h) + RXR-alpha(h) <==> IkappaB-beta(h):RXR-alpha(h) (binding)
Bcl-3(h) + RXR-alpha(h) <==> Bcl-3(h):RXR-alpha(h) (binding)
RXR-alpha(h) + RIP140(h) <==> RXR-alpha(h):RIP140(h) (binding)
RXR-alpha(h) + p300(m.s.) <==> RXR-alpha(h):p300(m.s.) (binding)
RXR-alpha(h) + COPR1(h) <==> RXR-alpha(h):COPR1(h) (binding)
RXR-alpha(h) + COPR2(h) <==> RXR-alpha(h):COPR2(h) (binding)
RelA-p65(h) + RXR-alpha(h) <==> RelA-p65(h):RXR-alpha(h) (binding)
S8(h) + RXR-alpha(h) <==> S8(h):RXR-alpha(h) (binding)
RXR-alpha(h) + DRIP205(h) <==> RXR-alpha(h):DRIP205(h) (binding)
RXR-alpha(h) + TRIP-3(h) <==> RXR-alpha(h):TRIP-3(h) (binding)
RXR-alpha(h) + ASC-1(h) <==> RXR-alpha(h):ASC-1(h) (binding)
RXR-alpha(h) + TRIP-5(h) <==> RXR-alpha(h):TRIP-5(h) (binding)
crabp-II(h) + RXR-alpha(h) <==> crabp-II(h):RXR-alpha(h) (binding)
RXR-alpha(h) + SHP(m) <==> RXR-alpha(h):SHP(m) (binding)
RXR-alpha(h) + p50(h) <==> p50(h):RXR-alpha(h) (binding)
trip6(h) + RXR-alpha(h) <==> trip6(h):RXR-alpha(h) (binding)
RXR-alpha(h) + TRIP7(h) <==> RXR-alpha(h):TRIP7(h) (binding)
RXR-alpha(h) + TRIP-8(h) <==> RXR-alpha(h):TRIP-8(h) (binding)
RXR-alpha(h) + CIP4(h) <==> RXR-alpha(h):CIP4(h) (binding)
RXR-alpha(h) + trip11(h) <==> RXR-alpha(h):trip11(h) (binding)
RXR-alpha(h) + COPS2(h) <==> RXR-alpha(h):COPS2(h) (binding)
TIF1a-short(h) + RXR-alpha(h) <==> TIF1a-short(h):RXR-alpha(h) (binding)
RXR-alpha(h) + SRC3-xbb2(h) <==> RXR-alpha(h):SRC3-xbb2(h) (binding)
RXR-alpha(h) + Oct-1(r) <==> RXR-alpha(h):Oct-1(r) (binding)
RXR-alpha(h) + POU2F1(m.s.) <==> RXR-alpha(h):POU2F1(m.s.) (binding)
RXR-alpha(h) + POU2F1(h) <==> RXR-alpha(h):POU2F1(h) (binding)
RXR-alpha(h) + T3R-alpha1(h) <==> RXR-alpha(h):T3R-alpha1(h) (binding)
RXR-alpha(h) + Oct-2(m.s.) <==> RXR-alpha(h):Oct-2(m.s.) (binding)
2 RXR-alpha(h) <==> (RXR-alpha(h))2 (oligomerization)
RXR-alpha(h) + TBP(h) <==> RXR-alpha(h):TBP(h) (binding)
RXR-alpha(h) + TBP(m.s.) <==> RXR-alpha(h):TBP(m.s.) (binding)
RXR-alpha(h) + NCOR1(m) <==> RXR-alpha(h):NCOR1(m) (binding)
PPARgamma2(m) + RXR-alpha(h) <==> PPARgamma2(m):RXR-alpha(h) (binding)
TRCp120(h) + RXR-alpha(h) <==> TRCp120(h):RXR-alpha(h) (binding)
FXR(r) + RXR-alpha(h) <==> FXR(r):RXR-alpha(h) (binding)
RXR-alpha(h) + PPARalpha(m) <==> RXR-alpha(h):PPARalpha(m) (binding)
RXR-alpha(h) --> SOX3(h) (DNA binding; transactivation).
FXR(h) + RXR-alpha(h) <==> FXR(h):RXR-alpha(h) (binding)
FXRbeta(m) + RXR-alpha(h) <==> FXRbeta(m):RXR-alpha(h) (binding)
LXRalpha-isoform1(h) + RXR-alpha(h) <==> LXRalpha-isoform1(h):RXR-alpha(h) (binding)
VDR(h) + RXR-alpha(h) <==> VDR(h):RXR-alpha(h) (binding)
calcitriol:VDR(h) + RXR-alpha(h) <==> calcitriol:RXR-alpha(h):VDR(h) (binding)
VDR(m) + RXR-alpha(h) <==> VDR(m):RXR-alpha(h) (binding)
IGFBP-5(h) + RXR-alpha(h) <==> IGFBP-5(h):RXR-alpha(h) (binding)
RXR-alpha(h) --> BGLAP(h) (DNA binding).
RXR-alpha(h) + SKIP(m.s.) <==> RXR-alpha(h):SKIP(m.s.) (binding)
RXR-alpha(h) + Grip1(m) <==> RXR-alpha(h):Grip1(m) (binding)
RXR-alpha(h) + ATP --MAPK(m.s.)--> RXR-alpha(h){pS260} + ADP (phosphorylation)
RXR-alpha(h) --> tPA(h) (DNA binding).
RXR-alpha(h) --> SULT2A1(h) (transactivation)
RXR-alpha(h) --> HNF4A(h) (DNA binding; transactivation).
RXR-alpha(h) --> THBD(h) (DNA binding).
RXR-alpha(h) --> TCF1(h) (DNA binding; transactivation).
RXR-alpha(h) --> CYP7A1(h) (transactivation)
RXR-alpha(h) --> FABP6(h) (DNA binding).
RXRA(h) --> RXR-alpha(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

108Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
260Phosphoserine (MAPK1;MAPK3;)12048211;10377179Phospho.ELM 6.0
249Phosphotyrosine (MAP2K4)10938283Phospho.ELM 6.0
32Phosphoserine16184197Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr9

 Promoter: 136356731 - 136358731Agilent_014791

chr9

 Promoter: 136356731 - 136358731GSE27584