| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 602 |
Name | BCL3 |
Synonymous | B-cell CLL/lymphoma 3;BCL3;B-cell CLL/lymphoma 3 |
Definition | B-cell leukemia/lymphoma 3|B-cell lymphoma 3 protein|B-cell lymphoma 3-encoded protein|BCL-3|chronic lymphatic leukemia protein|proto-oncogene BCL3 |
Position | 19q13.1-q13.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | NF-kappaB2-p52(h) + Bcl-3(h) <==> NF-kappaB2-p52(h):Bcl-3(h) (binding) | NF-kappaB1-p50(h) + Bcl-3(h) <==> NF-kappaB1-p50(h):Bcl-3(h) (binding). | p50(m) + Bcl-3(h) <==> p50(m):Bcl-3(h) (binding). | Tip60(h) + Bcl-3(h) + beta-catenin(h) + Reptin52(h) <==> Bcl-3(h):beta-catenin(h):Reptin52(h):Tip60(h) (binding) | Tip60(h) + Pontin52(h) + Bcl-3(h) <==> Bcl-3(h):Pontin52(h):Tip60(h) (binding) | Reptin52(h) + NF-kappaB1-p50(h):NF-kappaB1-p50(h) + beta-catenin(h) + Bcl-3(h) <==> Bcl-3(h):beta-catenin(h):NF-kappaB1-p50(h):NF-kappaB1-p50(h):Reptin52(h) (binding) | Pontin52(h) + Tip60(h) + NF-kappaB1-p50(h):NF-kappaB1-p50(h) + Bcl-3(h) <==> Pontin52(h):Tip60(h):NF-kappaB1-p50(h):NF-kappaB1-p50(h):Bcl-3(h) (binding) | TFIIA(m.s.) + Bcl-3(h) <==> TFIIA(m.s.):Bcl-3(h) (binding) | Bcl-3(h) + ATP --GSK3beta(h)--> Bcl-3(h){p} + ADP (phosphorylation) | Bcl-3(h) + ATP --GSK3alpha(h)--> Bcl-3(h){p} + ADP (phosphorylation) | Bcl-3(h) + GSK3alpha(h) <==> Bcl-3(h):GSK3alpha(h) (binding) | Bcl-3(h) + n ubiquitin(h) --> Bcl-3(h){ub(n)} (ubiquitination) | Bcl3(h) --> Bcl-3(h) (expression). | Bcl-3(h) + RXR-alpha(h) <==> Bcl-3(h):RXR-alpha(h) (binding) | Bcl-3(h) + T3R-beta1(r) <==> Bcl-3(h):T3R-beta1(r) (binding) | Bcl-3(h) + TFIIB(m.s.) <==> Bcl-3(h):TFIIB(m.s.) (binding) | TBP(m.s.) + Bcl-3(h) <==> TBP(m.s.):Bcl-3(h) (binding) | NF-kappaB1-p50(m.s.) + Bcl-3(h) <==> NF-kappaB1-p50(m.s.):Bcl-3(h) (binding) | Bcl-3(h) + ATP --GSK3beta(m.s.)--> Bcl-3(h){p} + ADP (phosphorylation) | Bcl-3(h) + ATP --ERK1(m.s.)--> Bcl-3(h){p} + ADP (phosphorylation) | Bcl-3(h) + 2 ATP --GSK3beta(h)--> Bcl-3(h){pS394}{pS398} + 2 ADP (phosphorylation) | Bcl-3(h) + n ubiquitin(h) --> Bcl-3(h){ub(n)} (ubiquitination) | Bcl-3(h) + n ubiquitin(m) --> Bcl-3(h){ub(n)} (ubiquitination) | NF-kappaB1-isoform1(h) + Bcl-3(h) <==> NF-kappaB1-isoform1(h):Bcl-3(h) (binding) | Bcl-3(h) + NF-kappaB2-p52(h) <==> Bcl-3(h):NF-kappaB2-p52(h) (binding) | HDAC1(m.s.) + Bcl-3(h) <==> HDAC1(m.s.):Bcl-3(h) (binding) | HDAC3(m.s.) + Bcl-3(h) <==> HDAC3(m.s.):Bcl-3(h) (binding) | hdac6(m.s.) + Bcl-3(h) <==> hdac6(m.s.):Bcl-3(h) (binding) | Bcl-3(h) --> PTN(m) (transactivation) | Bcl-3(h) --> Serpinb1a(m) (transactivation) | Bcl-3(h) --> Col5a1(m) (transactivation) | Bcl-3(h) --> Id2(m) (transactivation) | Bcl-3(h) --> Bmp1(m) (transactivation) | Bcl-3(h) --> Tbx15(m) (transactivation) | Bcl-3(h) --> Ccng2(m) (transactivation) | Bcl-3(h) --> Slpi(m) (transactivation) | Bcl-3(h) --/ Ppic(m) (transrepression) | Bcl-3(h) --/ Col8a1(m) (transrepression) | Bcl-3(h) --/ Cxcl1(m) (transrepression) | Bcl-3(h) --/ RGS16(m) (transrepression) | Pirin(h) + Bcl-3(h) <==> Pirin(h):Bcl-3(h) (binding) | Bcl-3(h) + Tip60(h) <==> Bcl-3(h):Tip60(h) (binding) | Bcl-3(h) + JAB1(h) <==> Bcl-3(h):JAB1(h) (binding) | Bcl-3(h) + BARD1(h) <==> Bcl-3(h):BARD1(h) (binding) | Bcl-3(h) + p50(h) <==> Bcl-3(h):p50(h) (binding) | Bcl-3(h) --/ Tnf(m) (transrepression) | Bcl3(h) --> Bcl-3(h) (expression). |
|---|
Post Translational Modification [Top] | |||
There is no record for BCL3 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr19 |
Promoter: 49942371 - 49944371 | Agilent_014791 |
chr19 |
Promoter: 49942371 - 49944371 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 49942371 - 49944371 | GSE27584 |
chr19 |
Promoter: 49942371 - 49944371 | Agilent_014791_44K |