| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5885 |
Name | RAD21 |
Synonymous | RAD21 homolog (S. pombe);RAD21;RAD21 homolog (S. pombe) |
Definition | NXP-1|SCC1 homolog|double-strand-break repair protein rad21 homolog|nuclear matrix protein 1|protein involved in DNA double-strand break repair|sister chromatid cohesion 1 |
Position | 8q24 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Rad21(h) --Caspase-3(h)--> Rad21-p65(h) + Rad21-p32(h) + protein remnants (processing) | Rad21(h) --Caspase-7(h)--> Rad21-p65(h) + Rad21-p32(h) + protein remnants (processing) | Wapl(h) + Pds5B(h) + Pds5A(h) + SMC-3(h) + SMC1(h) + Rad21(h) + SA-2(h) + SA-1(h) <==> Wapl(h):Pds5B(h):Pds5A(h):SMC-3(h):SMC1(h):Rad21(h):SA-2(h):SA-1(h) (binding) | Pds5B(h) + Pds5A(h) + SA-2(h) + SMC-3(h) + Rad21(h) + Wapl(h) <==> Pds5B(h):Pds5A(h):SA-2(h):SMC-3(h):Rad21(h):Wapl(h) (binding) | SMC-3(h) + SMC1(h) + Rad21(h) + SA-1(h) + SA-2(h) + Pds5A(h) + Pds5B(h) + Wapl(h) + Sororin(h) <==> SMC-3(h):SMC1(h):Rad21(h):SA-1(h):SA-2(h):Pds5A(h):Pds5B(h):Wapl(h):Sororin(h) (binding) | Pds5B(h) + SMC1(h) + SMC-3(h) + Rad21(h) + Sororin(h) <==> Pds5B(h):SMC1(h):SMC-3(h):Rad21(h):Sororin(h) (binding) | Rad21(h) + SMC-3(h) + Pds5B(h) + Pds5A(h) + Sororin(m.s.) <==> Rad21(h):SMC-3(h):Pds5B(h):Pds5A(h):Sororin(m.s.) (binding) | Rad21(h) + SMC-3(h) + Sororin(m.s.) <==> Rad21(h):SMC-3(h):Sororin(m.s.) (binding) | Rad21(h) + Pds5A(h) + Pds5B(h) + SA-2(h) + SMC1(h) + Wapl(h) <==> Rad21(h):Pds5A(h):Pds5B(h):SA-2(h):SMC1(h):Wapl(h) (binding) | Rad21(h) + Pds5B(h) + Pds5A(h) + Wapl(h) <==> Rad21(h):Pds5B(h):Pds5A(h):Wapl(h) (binding) | Rad21(h) + SMC-3(h) + Wapl(h) <==> Rad21(h):SMC-3(h):Wapl(h) (binding) | Rad21(h) --> Rad21-p65(h) + protein remnants (cleavage) | Rad21(h) + 9 ATP --> Rad21(h){pS46}{pS138}{pT144}{pS153}{pS175}{pT312}{pS454}{pS459}{pS466} + 9 ADP (phosphorylation) | SMC1(h) + Rad21(h) <==> SMC1(h):Rad21(h) (binding) | SMC1(h) + SMC-3(h) + Rad21(h) + SA-1(h) <==> SMC1(h):SMC-3(h):Rad21(h):SA-1(h) (binding) | SMC1(h) + SMC-3(h) + Rad21(h) + SA-2(h) <==> SMC1(h):SMC-3(h):Rad21(h):SA-2(h) (binding) | SRp55(h) + SRp75(h) + SRm300(h) + Rad21(h) + SMC-3(h) + SMC1(h) + SRm160(h) <==> SRp55(h):SRp75(h):SRm300(h):Rad21(h):SMC-3(h):SMC1(h):SRm160(h) (binding) | SRm160(h) + Rad21(h) + SMC1(h) + SRm300(h) <==> SRm160(h):Rad21(h):SMC1(h):SRm300(h) (binding) | Ku70(h) + Ccte(h) + Pds5A(h) + PPIL1(h) + eIF-3gamma(h) + SAFB1(h) + Wapl(h) + Rad21(h) + SMC-3(h) + SMC1(h) + CAPER-alpha(h) + CNOT3(h) + NCoA-5(h) + SIAHBP1(h) + FBP(h) + HYPA(h) + SKIP(h) + SRm300(h) + SRm160(h) + p54nrb/NonO(h) + rbm25(h) + rbm8A(h) + Pinin(h) + Prp19(h) + cdc5L(h) + Snrp116(h) + Prpf8(h) + Sf3b-4(h) + Sf3b-2(h) + hnRNPM(h) + hnRNP-G(h) <==> Ku70(h):Ccte(h):Pds5A(h):PPIL1(h):eIF-3gamma(h):SAFB1(h):Wapl(h):Rad21(h):SMC-3(h):SMC1(h):CAPER-alpha(h):CNOT3(h):NCoA-5(h):SIAHBP1(h):FBP(h):HYPA(h):SKIP(h):SRm300(h):SRm160(h):p54nrb/NonO(h):rbm25(h):rbm8A(h):Pinin(h):Prp19(h):cdc5L(h):Snrp116(h):Prpf8(h):Sf3b-4(h):Sf3b-2(h):hnRNPM(h):hnRNP-G(h) (binding) | Rad21(h) + SRm160(h) <==> Rad21(h):SRm160(h) (binding) | Rad21(h) + n ATP --> Rad21(h){p}n (phosphorylation) | Rad21(h) + SMC-3(h) + SMC1(h) + CHLR1(h) <==> Rad21(h):SMC-3(h):SMC1(h):CHLR1(h) (binding) | RAD21(h) --> Rad21(h) (expression). | Rad21(h) --Separin(h)--> protein remnants (cleavage) | Rad21(h) --Separin(m.s.)--> protein remnants (cleavage) | Rad21(h) --Separin(x)--> protein remnants (cleavage) | RAD21(h) --> Rad21(h) (expression). |
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Post Translational Modification [Top] | |||
There is no record for RAD21 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr8 |
Promoter: 117955682 - 117957682 | Agilent_014791 |
chr8 |
Promoter: 117955682 - 117957682 | GSE27584 |
chr8 |
Promoter: 117955682 - 117957682 | Agilent_014791_44K |