| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 57591 |
Name | MKL1 |
Synonymous | megakaryoblastic leukemia (translocation) 1;MKL1;megakaryoblastic leukemia (translocation) 1 |
Definition | MKL/myocardin-like protein 1|Mkl1 variant 1 Mkl1_S|basic, SAP and coiled-coil domain|megakaryoblastic leukemia 1 protein|megakaryocytic acute leukemia protein|myocardin-related transcription factor A |
Position | 22q13 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | mkl1(h) + Ubc9(m) <==> mkl1(h):Ubc9(m) (binding) | mkl1(h) + Ubc9(m) <==> mkl1(h):Ubc9(m) (binding) | mkl1(h) + 3 sumo1(m.s.) --> mkl1(h){sumoK499}{sumoK576}{sumoK624} (sumoylation) | mkl1(h) + sumo1(m.s.) --Aos1(h):SAE2(h),Ubc9(m)--> mkl1(h){sumoK499}{sumoK576}{sumoK624} (sumoylation) | mkl1(h) + SUMO2(m) --> mkl1(h){sumo2} (sumoylation) | mkl1(h) + sumo3(m) --> mkl1(h){sumo3} (sumoylation) | mkl1(h) + SRF(m) <==> mkl1(h):SRF(m) (binding) | MKL1(h) --> mkl1(h) (expression). | mkl1(h) + sumo1(h) --> mkl1(h){sumo} (sumoylation) | mkl1(h) --> mkl1(h) (translocation) | mkl1(h) --> MYH9(h) (transactivation) | mkl1(h) --> PDE1C(h) (transactivation) | mkl1(h) --> MYL9(h) (transactivation) | mkl1(h) --> SDPR(h) (transactivation) | mkl1(h) --> VGLL3(h) (transactivation) | mkl1(h) --> TPM1(h) (transactivation) | mkl1(h) --> HELLS(h) (transactivation) | mkl1(h) --> DENND2A(h) (transactivation) | mkl1(h) --> PPP1R12A(h) (transactivation) | mkl1(h) --> TMEM30A(h) (transactivation) | mkl1(h) --> PHLDB2(h) (transactivation) | mkl1(h) --/ JUN(h) (transrepression) | mkl1(h) --/ YPEL2(h) (transrepression) | mkl1(h) --/ Gdpd1(h) (transrepression) | mkl1(h) --/ BCL6(h) (transrepression) | mkl1(h) --/ GLS(h) (transrepression) | mkl1(h) --/ FBXO32(h) (transrepression) | mkl1(h) --/ HMGA2(h) (transrepression) | mkl1(h) --/ KLF4(h) (transrepression) | mkl1(h) --/ AMPD3(h) (transrepression) | MKL1(h) --> mkl1(h) (expression). | mkl1(h) --> mkl1(h) (translocation) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 6 | Phosphoserine. | Swiss-Prot 53.0 | 6 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 454 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr22 |
Promoter: 39362136 - 39364136 | Agilent_014791 |
chr22 |
Promoter: 39362136 - 39364136 | GSE27584 |
chr22 |
Promoter: 39362136 - 39364136 | Agilent_014791_44K |