| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5753 |
Name | PTK6 |
Synonymous | protein tyrosine kinase 6;PTK6;protein tyrosine kinase 6 |
Definition | PTK6 protein tyrosine kinase 6|breast tumor kinase|protein-tyrosine kinase 6|protein-tyrosine kinase BRK|tyrosine-protein kinase BRK |
Position | 20q13.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ErbB1-p170(h) + PTK6(h) <==> ErbB1-p170(h):PTK6(h) (binding) | ErbB2(h) + PTK6(h) <==> ErbB2(h):PTK6(h) (binding) | ErbB3-isoform1(h){pY1276} + PTK6(h) <==> ErbB3-isoform1(h){pY1276}:PTK6(h) (binding) | ErbB4(h) + PTK6(h) <==> ErbB4(h):PTK6(h) (binding) | PTK6(h) + ATP --> PTK6(h){pY} + ADP (phosphorylation) | PTK6(h) + ErbB3(h){pY} <==> PTK6(h):ErbB3(h){pY} (binding) | PTK6(h) --> PTK6(h) (expression). | PTK6(h) --> PTK6(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 342 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 447 | Phosphotyrosine. | Swiss-Prot 53.0 | 447 | Phosphotyrosine (Brk) | 12121988 | Phospho.ELM 6.0 | 342 | Phosphotyrosine (Brk) | 12121988 | Phospho.ELM 6.0 | 351 | Phosphotyrosine | 12121988 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr20 |
Promoter: 61638651 - 61640651 | Agilent_014791 |
chr20 |
Promoter: 61638651 - 61640651 | GoldenGate_Methylation_Cancer_Panel_I |
chr20 |
Promoter: 61638651 - 61640651 | GSE27584 |
chr20 |
Promoter: 61638651 - 61640651 | Agilent_014791_44K |