| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5359 |
Name | PLSCR1 |
Synonymous | phospholipid scramblase 1;PLSCR1;phospholipid scramblase 1 |
Definition | PL scramblase 1|ca(2+)-dependent phospholipid scramblase 1|erythrocyte phospholipid scramblase |
Position | 3q23 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PLSCR1(h) + ATP --Src(m.s.)--> PLSCR1(h){p} + ADP (phosphorylation) | PLSCR1(h) + ATP --Src(h)--> PLSCR1(h){pY} + ADP (phosphorylation) | Shc-1(m) + PLSCR1(h) <==> Shc-1(m):PLSCR1(h) (binding) | PLSCR1(h) --> PLSCR1(h) (expression). | PLSCR1(h) + ATP --> PLSCR1(h){pY} + ADP (phosphorylation) | ErbB1(h) + PLSCR1(h) <==> ErbB1(h):PLSCR1(h) (binding) | PLSCR1(h) + Shc-1-p66(h) <==> PLSCR1(h):Shc-1-p66(h) (binding) | Shc-1-p46(h) + PLSCR1(h) <==> Shc-1-p46(h):PLSCR1(h) (binding) | Shc-1-p52(h) + PLSCR1(h) <==> Shc-1-p52(h):PLSCR1(h) (binding) | ANT3(h) + PLSCR1(h) <==> ANT3(h):PLSCR1(h) (binding) | Annexin 11(h) + PLSCR1(h) <==> Annexin 11(h):PLSCR1(h) (binding) | CNTFR(h) + PLSCR1(h) <==> CNTFR(h):PLSCR1(h) (binding) | crk(h) + PLSCR1(h) <==> crk(h):PLSCR1(h) (binding) | cryptochrome1(h) + PLSCR1(h) <==> cryptochrome1(h):PLSCR1(h) (binding) | EWS(h) + PLSCR1(h) <==> EWS(h):PLSCR1(h) (binding) | G-alpha-i2(h) + PLSCR1(h) <==> G-alpha-i2(h):PLSCR1(h) (binding) | HOXA1(h) + PLSCR1(h) <==> HOXA1(h):PLSCR1(h) (binding) | hoxa9(h) + PLSCR1(h) <==> hoxa9(h):PLSCR1(h) (binding) | HOXB6(h) + PLSCR1(h) <==> HOXB6(h):PLSCR1(h) (binding) | DRBP76(h) + PLSCR1(h) <==> DRBP76(h):PLSCR1(h) (binding) | LASP-1(h) + PLSCR1(h) <==> LASP-1(h):PLSCR1(h) (binding) | MCS(h) + PLSCR1(h) <==> MCS(h):PLSCR1(h) (binding) | 2-oxoglutarate dehydrogenase E1 component, mitochondrial(h) + PLSCR1(h) <==> 2-oxoglutarate dehydrogenase E1 component, mitochondrial(h):PLSCR1(h) (binding) | PLSCR1(h) + paraplegin(h) <==> PLSCR1(h):paraplegin(h) (binding) | PLSCR1(h) + UGTL(h) <==> PLSCR1(h):UGTL(h) (binding) | PLSCR1(h) + vasp(h) <==> PLSCR1(h):vasp(h) (binding) | PLSCR1(h) + ZFM1(h) <==> PLSCR1(h):ZFM1(h) (binding) | PLSCR1(h) + PLZF(h) <==> PLSCR1(h):PLZF(h) (binding) | PLSCR1(h) + APG12(h) <==> PLSCR1(h):APG12(h) (binding) | PLSCR1(h) + GRIN2(h) <==> PLSCR1(h):GRIN2(h) (binding) | PLSCR1(h) + dazap2(h) <==> PLSCR1(h):dazap2(h) (binding) | PLSCR1(h) + Sprouty2(h) <==> PLSCR1(h):Sprouty2(h) (binding) | PLSCR1(h) + TF6(h) <==> PLSCR1(h):TF6(h) (binding) | PLSCR1(h) + Glutaredoxin-3(h) <==> PLSCR1(h):Glutaredoxin-3(h) (binding) | PLSCR1(h) + CFIM68(h) <==> PLSCR1(h):CFIM68(h) (binding) | PLSCR1(h) + depp(h) <==> PLSCR1(h):depp(h) (binding) | PLSCR1(h) + Borg5(h) <==> PLSCR1(h):Borg5(h) (binding) | PLSCR1(h) + PHRIP(h) <==> PLSCR1(h):PHRIP(h) (binding) | PLSCR1(h) + Hey2(h) <==> PLSCR1(h):Hey2(h) (binding) | PLSCR1(h) + 6-phosphogluconolactonase(h) <==> PLSCR1(h):6-phosphogluconolactonase(h) (binding) | PLSCR1(h) + KLIP1(h) <==> PLSCR1(h):KLIP1(h) (binding) | PLSCR1(h) + ZFML(h) <==> PLSCR1(h):ZFML(h) (binding) | PLSCR1(h) + FBLN4(h) <==> PLSCR1(h):FBLN4(h) (binding) | PLSCR1(h) + IP6K2(h) <==> PLSCR1(h):IP6K2(h) (binding) | PLSCR1(h) + znf581(h) <==> PLSCR1(h):znf581(h) (binding) | PLSCR1(h) + PCQAP(h) <==> PLSCR1(h):PCQAP(h) (binding) | PLSCR1(h) + AGS1(h) <==> PLSCR1(h):AGS1(h) (binding) | PLSCR1(h) + TSRC1(h) <==> PLSCR1(h):TSRC1(h) (binding) | PLSCR1(h) + RC68(h) <==> PLSCR1(h):RC68(h) (binding) | PLSCR1(h) + NECAP2(h) <==> PLSCR1(h):NECAP2(h) (binding) | PLSCR1(h) + NPDC1(h) <==> PLSCR1(h):NPDC1(h) (binding) | PLSCR1(h) + plscr3(h) <==> PLSCR1(h):plscr3(h) (binding) | PLSCR1(h) + plscr4(h) <==> PLSCR1(h):plscr4(h) (binding) | PLSCR1(h) + ntn4(h) <==> PLSCR1(h):ntn4(h) (binding) | PLSCR1(h) + GI24(h) <==> PLSCR1(h):GI24(h) (binding) | PLSCR1(h) + fam113a(h) <==> PLSCR1(h):fam113a(h) (binding) | PLSCR1(h) + EGFL9(h) <==> PLSCR1(h):EGFL9(h) (binding) | PLSCR1(h) + NOC4(h) <==> PLSCR1(h):NOC4(h) (binding) | PLSCR1(h) + FBL18(h) <==> PLSCR1(h):FBL18(h) (binding) | PLSCR1(h) + kiaa1683(h) <==> PLSCR1(h):kiaa1683(h) (binding) | PLSCR1(h) + fam103a1(h) <==> PLSCR1(h):fam103a1(h) (binding) | PLSCR1(h) + KAP4.12(h) <==> PLSCR1(h):KAP4.12(h) (binding) | PLSCR1(h) + c16orf48(h) <==> PLSCR1(h):c16orf48(h) (binding) | PLSCR1(h) + C4orf42(h) <==> PLSCR1(h):C4orf42(h) (binding) | PLSCR1(h) + znf764(h) <==> PLSCR1(h):znf764(h) (binding) | PLSCR1(h) + dtx2(h) <==> PLSCR1(h):dtx2(h) (binding) | PLSCR1(h) + dhrs1(h) <==> PLSCR1(h):dhrs1(h) (binding) | PLSCR1(h) + sialidase-4(h) <==> PLSCR1(h):sialidase-4(h) (binding) | PLSCR1(h) + c12orf12(h) <==> PLSCR1(h):c12orf12(h) (binding) | PLSCR1(h) + c10orf62(h) <==> PLSCR1(h):c10orf62(h) (binding) | PLSCR1(h) --> PLSCR1(h) (expression). | EGF(m.s.) --> PLSCR1(h) (increase of abundance) |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 69 | Phosphotyrosine (by ABL). | Swiss-Prot 53.0 | 74 | Phosphotyrosine (by ABL). | Swiss-Prot 53.0 | 161 | Phosphothreonine (by PKC). | Swiss-Prot 53.0 | 234 | S-palmitoyl cysteine (Potential). | Swiss-Prot 53.0 | 237 | S-palmitoyl cysteine (Potential). | Swiss-Prot 53.0 | 239 | S-palmitoyl cysteine (Potential). | Swiss-Prot 53.0 | 240 | S-palmitoyl cysteine (Potential). | Swiss-Prot 53.0 | 69 | Phosphotyrosine (Abl;Src) | 11390389;12871937 | Phospho.ELM 6.0 | 74 | Phosphotyrosine (Abl;Src) | 11390389;12871937 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr3 |
Promoter: 147744686 - 147746686 | Agilent_014791 |
chr3 |
Promoter: 147744686 - 147746686 | GSE27584 |
chr3 |
Promoter: 147744686 - 147746686 | Agilent_014791_44K |