| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 51176 |
Name | LEF1 |
Synonymous | lymphoid enhancer-binding factor 1;LEF1;lymphoid enhancer-binding factor 1 |
Definition | T cell-specific transcription factor 1-alpha|TCF1-alpha |
Position | 4q23-q25 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | LEF1-isoform1(h) --> CD4(m) (DNA binding; transregulation). | LEF1-isoform1(h) --> ADA(h) (DNA binding; transregulation). | LEF1-isoform1(h) --> CCND1(h) (DNA binding; transregulation). | LEF1-isoform1(h) --> siamois(x) (DNA binding). | LEF1-isoform1(h) --> Engrailed-2(x) (DNA binding). | LEF1-isoform1(h) --> TCR-alpha(h) (DNA binding; transregulation). | LEF1-isoform1(h) --> Xnr3(x) (DNA binding). | LEF1-isoform1(h) --> HIV-1(HIV1) (DNA binding). | LEF1-isoform1(h) --> FN1(x) (DNA binding). | LEF1-isoform1(h) --> twin(x) (DNA binding). | LEF1-isoform1(h) + beta-catenin(m) <==> LEF1-isoform1(h):beta-catenin(m) (binding). | LEF1-isoform1(h) + beta-catenin(h) <==> LEF1-isoform1(h):beta-catenin(h) (binding) | LEF1-isoform1(h) + Smad3(h) <==> LEF1-isoform1(h):Smad3(h) (binding) | Grg-1(m) + LEF1-isoform1(h) <==> Grg-1(m):LEF1-isoform1(h) (binding) | LEF1-isoform1(h) + TLE-2(h) <==> LEF1-isoform1(h):TLE-2(h) (binding) | ESG3(m) + LEF1-isoform1(h) <==> ESG3(m):LEF1-isoform1(h) (binding) | Grg4(m) + LEF1-isoform1(h) <==> Grg4(m):LEF1-isoform1(h) (binding) | LEF1-isoform1(h) + NLK(m) <==> LEF1-isoform1(h):NLK(m) (binding) | LEF1-isoform1(h) + 2 ATP --NLK(m)--> LEF1-isoform1(h){pS166}{pT155} + 2 ADP (phosphorylation) | LEF1-isoform1(h) --> TCR-Vbeta 8.1(h) (DNA binding; transactivation). | LEF1-isoform1(h) --> DCT(h) (DNA binding; transactivation). | LEF1-isoform1(h) --> MITF(h) (DNA binding; transactivation). | LEF1-isoform1(h) --> Bop1(m) (DNA binding). | LEF1-isoform1(h) --> SPP1(r) (DNA binding). | LEF1-isoform1(h) --> Zfp339(m) (DNA binding; transactivation). | LEF1-isoform1(h) --> IL-4(h) (DNA binding). | Lef1(h) --> LEF1-isoform1(h) (expression). | Lef1(h) --> LEF-1B(h) (expression). | LEF-1(h) --> prl(h) (DNA binding). | LEF-1(h) --> IL-4(h) (DNA binding). | LEF-1(h) --> AR(h) (DNA binding). | LEF-1(h) --> Lef1(h) (DNA binding). | LEF-1(h) --> POU3F2(m) (DNA binding). | LEF-1(h) --> TRAC(h) (DNA binding). | LEF-1(h) --> DCT(h) (transactivation) | MITF(m.s.) + LEF-1(h) <==> MITF(m.s.):LEF-1(h) (binding) | LEF-1(h) --> MITF(h) (transactivation) | LEF-1(h) + NLK(m.s.) <==> LEF-1(h):NLK(m.s.) (binding) | LEF-1(h) + NLK(m.s.) + beta-catenin(m.s.) <==> LEF-1(h):NLK(m.s.):beta-catenin(m.s.) (binding) | LEF-1(h) + 2 ATP --NLK(m.s.)--> LEF-1(h){pT155}{pS166} + 2 ADP (phosphorylation) | beta-catenin(m.s.) + LEF-1(h) <==> beta-catenin(m.s.):LEF-1(h) (binding) | LEF-1(h) --> c-myc(h) (transactivation) | Lef1(h) --> LEF-1(h) (expression). | Lef1(h) --> LEF1-isoform2(h) (expression). | LEF1-isoform3(h) + MITF(h) <==> LEF1-isoform3(h):MITF(h) (binding) | Lef1(h) --> LEF1-isoform3(h) (expression). | Lef1(h) --> LEF1-isoform4(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 27 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (Bysimilarity). | Swiss-Prot 53.0 | 269 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (Bysimilarity). | Swiss-Prot 53.0 | 155 | Phosphothreonine (NLK) | 12556497 | Phospho.ELM 6.0 | 166 | Phosphoserine (NLK) | 12556497 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr4 |
Promoter: 109308527 - 109310527 | Agilent_014791 |
chr4 |
Promoter: 109308527 - 109310527 | GSE27584 |
chr4 |
Promoter: 109308527 - 109310527 | Agilent_014791_44K |
chr4 |
Promoter: 109308527 - 109310527 | Agilent_014791 |