| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 50616 |
Name | IL22 |
Synonymous | interleukin 22;IL22;interleukin 22 |
Definition | IL-10-related T-cell-derived inducible factor|IL-10-related T-cell-derived-inducible factor|cytokine Zcyto18|interleukin-22 |
Position | 12q15 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IL-22(h) --> STAT3(h) (activation; phosphorylation) | IL-22(h) --> STAT1(h) (activation; phosphorylation) | IL-22(h) + IL-10R2(h) <==> IL-22(h):IL-10R2(h) (binding) | IL-22(h) --> STAT5(h) (activation; phosphorylation) | IL-22(h) + IL-22BP(h) <==> IL-22(h):IL-22BP(h) (binding) | IL-22(h) + IL-22R1(h) <==> IL-22(h):IL-22R1(h) (binding) | IL-22(h) + IL-22R1(h) + IL-10R2(h) <==> IL-22(h):IL-22R1(h):IL-10R2(h) (binding) | IL-22(h) --> Jak1(r){pY} (activation; phosphorylation) | IL-22(h) --> Tyk2(r){pY} (activation; phosphorylation) | IL22(h) --> IL-22(h) (expression). | IL-22(h) --> NOS2(h) (transactivation) | IL-22(h) + IL-10R2(h) <==> IL-22(h):IL-10R2(h) (binding) | IL-22R1(h) + IL-22(h) <==> IL-22R1(h):IL-22(h) (binding) | IL-10R2(m.s.) + IL-22R1(h) + IL-22(h) <==> IL-10R2(m.s.):IL-22R1(h):IL-22(h) (binding) | IL-22(h) --> STAT1(h){pY701} (increase of phosphorylation) | IL-22(h) --> STAT3(h){pY705} (increase of phosphorylation) | IL-22(h) --> STAT5(h){pY} (increase of phosphorylation) | IL-22(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | IL-22(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | IL-22(h) --> AKT(h){p} (increase of phosphorylation) | IL-22(h) --> IL6(h) (transactivation) | IL-22(h) --> IL8(h) (transactivation) | IL-22(h) --> TNF(h) (transactivation) | IL-22(h) --> SOCS3(h) (transactivation) | IL-22(h) --> IL-8(h) (increase of abundance) | IL-22(h) --> STAT1(m){pY} (increase of phosphorylation) | IL-22(h) --> STAT3(m){pY705} (increase of phosphorylation) | IL-22(h) --> STAT5(m){pY} (increase of phosphorylation) | 2 IL-22(h) <==> (IL-22(h))2 (binding) | 4 IL-22(h) <==> (IL-22(h))4 (binding) | IL-22(h) + IL-22BP-isoform2(h) <==> IL-22(h):IL-22BP-isoform2(h) (binding) | IL22(h) --> IL-22(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 54 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 68 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 97 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for IL22 | ||