| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5045 |
Name | FURIN |
Synonymous | furin (paired basic amino acid cleaving enzyme);FURIN;furin (paired basic amino acid cleaving enzyme) |
Definition | FES upstream region|dibasic processing enzyme|furin|furin, membrane associated receptor protein|paired basic amino acid residue-cleaving enzyme|proprotein convertase subtilisin/kexin type 3 |
Position | 15q26.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PACE(h) --> BMP4(x) (processing) | FURIN(h) --> PACE(h) (expression). | sortilin(h) --PACE(h)--> protein remnants + sortilin-A78(h) (processing) | Notch1(m) --PACE(h)--> Notch1EC(m) + Notch1TM(m) (processing) | ED1-isoform1(h) --PACE(h)--> sED1-isoform1(h) + protein remnants (processing) | Notch2(h) --PACE(h)--> Notch2EC(h) + Notch2TM(h) (cleavage) | FURIN(h) --> PACE(h) (expression). | IGF-1R(h) --PACE(h)--> IGF-1R-alpha-p130(h) + IGF-1R-beta-p97(h) (cleavage) | IGF-1R(h) --PACE(h)--> IGF-1R-beta-p97(h) + protein remnants (cleavage) | NGF(m) --PACE(h)--> NGF-p13(m) + NGF-p17(m) + protein remnants (processing) | NGF(m) --PACE(h)--> NGF-p13(m) + protein remnants (processing) | PC1(m) --PACE(h)--> PC1-p12.5(m) + protein remnants (cleavage) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 387 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 440 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 553 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 773 | Phosphoserine (by CK2). | Swiss-Prot 53.0 | 775 | Phosphoserine (by CK2). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for FURIN | ||