| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4780 |
Name | NFE2L2 |
Synonymous | nuclear factor, erythroid 2-like 2;NFE2L2;nuclear factor, erythroid 2-like 2 |
Definition | HEBP1|NF-E2-related factor 2|NFE2-related factor 2|nuclear factor (erythroid-derived 2)-like 2|nuclear factor erythroid 2-related factor 2|nuclear factor erythroid-derived 2-like 2|nuclear factor, erythroid derived 2, like 2 |
Position | 2q31 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PPARgamma1(m) + Nrf2(h) <==> PPARgamma1(m):Nrf2(h) (binding). | MafG(h) + Nrf2(h) <==> Nrf2(h):MafG(h) (binding) | Nrf2(h) --> Fth1(m) (DNA binding). | Nrf2(h) + MafK(h) <==> Nrf2(h):MafK(h) (binding) | c-Jun(h) + Nrf2(h) <==> c-Jun(h):Nrf2(h) (binding) | MafG(h) + Nrf2(h) <==> MafG(h):Nrf2(h) (binding) | MafK(h) + Nrf2(h) <==> MafK(h):Nrf2(h) (binding) | NF-E2 p45(h) + Nrf2(h) <==> NF-E2 p45(h):Nrf2(h) (binding) | Nrf2(h) --> GSS(h) (DNA binding). | Nrf2(h) --> ADSL(h) (DNA binding). | Nrf2(h) + JunD(h) <==> Nrf2(h):JunD(h) (binding) | Nrf2(h) + n ubiquitin(h) --> Nrf2(h){ub}n (ubiquitination) | Nrf2(h) + KEAP1(m.s.) <==> Nrf2(h):KEAP1(m.s.) (binding) | Nrf2(h) + KEAP1(h) <==> Nrf2(h):KEAP1(h) (binding) | Nrf2(h) + CUL3(h) + KEAP1(h) <==> Nrf2(h):CUL3(h):KEAP1(h) (binding) | Nrf2(h) + n ubiquitin(h) --E1(m.s.),Ubc5C(m.s.),Roc1(h):CUL3(h):KEAP1(m.s.)--> Nrf2(h){ub}n (ubiquitination) | Nrf2(h) --> Nrf2(h) (translocation) | Nrf2(h) --> GSTP1(h) (DNA binding). | Nrf2(h) --> Abcc2(m) (DNA binding). | CUL3(h) + Nrf2(h) <==> CUL3(h):Nrf2(h) (binding) | Nrf2(h) --> Nrf2(h) (translocation) | Nrf2(h) --> GCLC(h) (DNA binding). | Nrf2(h) --> GCLM(h) (DNA binding). | Nrf2(h) --> Akr1b3(m) (DNA binding). | Nrf2(h) + NRPB(h) <==> Nrf2(h):NRPB(h) (binding) | NRPB(h) + Nrf2(h) <==> NRPB(h):Nrf2(h) (binding) | Nrf2(h) --> HMOX1(h) (transactivation) | Nrf2(h) --> NQO1(h) (transactivation) | Nrf2(h) + ATP --(CKII-alpha(h))2:(CKII-beta(h))2--> Nrf2(h){p} + ADP (phosphorylation) | Nrf2(h) + ATP --> Nrf2(h){p} + ADP (phosphorylation) | Nrf2(h) --> GNAI2(h) (DNA binding). | Nrf2(h) --> KRT16(h) (DNA binding). | Nrf2(h) --> S100A6(h) (DNA binding). | Nrf2(h) --> PREPL(h) (DNA binding). | Nrf2(h) --> C2orf34(h) (DNA binding). | Nrf2(h) --> UGT1A10(h) (transactivation) | Nrf2(h) --> UGT1A8(h) (transactivation) | NFE2L2(h) --> Nrf2(h) (expression). | Nrf2(h) --> Nrf2(h) (translocation) | Nrf2(h) --> Nrf2(h) (translocation) | Nrf2-isoform1(h) --> HBB(h) (DNA binding). | Nrf2-isoform1(h) --> Nrf2-isoform1(h) (translocation) | Nrf2-isoform1(h) + n ubiquitin(h) --> Nrf2-isoform1(h){ub}n (ubiquitination) | Roc1(m.s.) + CUL3(m.s.) + KEAP1(h) + Nrf2-isoform1(h) <==> Roc1(m.s.):CUL3(m.s.):KEAP1(h):Nrf2-isoform1(h) (binding) | Nrf2-isoform1(h) + ATP --(CKII-alpha(h))2:(CKII-beta(h))2--> Nrf2-isoform1(h){p} + ADP (phosphorylation) | NFE2L2(h) --> Nrf2-isoform1(h) (expression). | Nrf2-isoform1(h) --> Nrf2-isoform1(h) (translocation) | PPARgamma1(m) + Nrf2-isoform2(h) <==> PPARgamma1(m):Nrf2-isoform2(h) (binding) | NFE2L2(h) --> Nrf2-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 40 | Phosphoserine (by PKC). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 177837163 - 177839163 | Agilent_014791 |
chr2 |
Promoter: 177837163 - 177839163 | GSE27584 |
chr2 |
Promoter: 177837163 - 177839163 | Agilent_014791_44K |
chr2 |
Promoter: 177837163 - 177839163 | Agilent_014791 |