Entrez Gene

Basic Information
Gene ID	4739
Name	NEDD9
Synonymous	neural precursor cell expressed, developmentally down-regulated 9;NEDD9;neural precursor cell expressed, developmentally down-regulated 9
Definition	Cas scaffolding protein family member 2\|Crk-associated substrate related protein Cas-L\|Enhancer of filamentation 1 p55\|cas-like docking\|enhancer of filamentation 1\|neural precursor cell expressed developmentally down-regulated protein 9\|p130Cas-related pr
Position	6p24.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
HEF1(h) + Smad3(h) <==> HEF1(h):Smad3(h) (binding)
FAK1(h) + HEF1(h) <==> FAK1(h):HEF1(h) (binding)
HEF1(h) + ATP --Pyk2-isoform1(h){p}--> HEF1(h){p} + ADP (phosphorylation)
HEF1(h) + ATP --> HEF1(h){pY} + ADP (phosphorylation)
crk(h) + HEF1(h) <==> crk(h):HEF1(h) (binding)
HEF1(h) + crk(m.s.) <==> HEF1(h):crk(m.s.) (binding)
HEF1(h) + CrkL(m.s.) <==> HEF1(h):CrkL(m.s.) (binding)
HEF1(h) + CrkL(h) <==> HEF1(h):CrkL(h) (binding)
HEF1(h) + Pyk2(h) <==> HEF1(h):Pyk2(h) (binding)
HEF1(h) + Lyn(h) <==> HEF1(h):Lyn(h) (binding)
HEF1(h) + Fyn(h) <==> HEF1(h):Fyn(h) (binding)
Id2(h) + HEF1(h) <==> Id2(h):HEF1(h) (binding)
NEDD9(h) --> HEF1(h) (expression).
HEF1(h){pY} --> HEF1(h) + p (dephosphorylation)
Smad3(m.s.) + HEF1(h) <==> Smad3(m.s.):HEF1(h) (binding)
Fzr1(m.s.) + HEF1(h) <==> Fzr1(m.s.):HEF1(h) (binding)
2 HEF1(h) <==> (HEF1(h))2 (oligomerization)
Id2(h) + HEF1(h) <==> Id2(h):HEF1(h) (binding)
E12(h) + HEF1(h) <==> E12(h):HEF1(h) (binding)
E47(h) + HEF1(h) <==> E47(h):HEF1(h) (binding)
NEDD9(h) --> HEF1(h) (expression).
Smad3(m.s.) --/ HEF1(h) (decrease of abundance)
APC10(m.s.) --/ HEF1(h) (decrease of abundance)
Fzr1(m.s.) --/ HEF1(h) (decrease of abundance)

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
12	Phosphotyrosine.		Swiss-Prot 53.0
92	Phosphotyrosine (By similarity).		Swiss-Prot 53.0
166	Phosphotyrosine.		Swiss-Prot 53.0
177	Phosphotyrosine (By similarity).		Swiss-Prot 53.0
189	Phosphotyrosine (By similarity).		Swiss-Prot 53.0
166	Phosphotyrosine	12522270	Phospho.ELM 6.0
12	Phosphotyrosine	15144186	Phospho.ELM 6.0

Transcription Factors [Top]