| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4323 |
Name | MMP14 |
Synonymous | matrix metallopeptidase 14 (membrane-inserted);MMP14;matrix metallopeptidase 14 (membrane-inserted) |
Definition | matrix metalloproteinase-14|membrane type 1 metalloprotease|membrane-type-1 matrix metalloproteinase |
Position | 14q11.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | MMP14(h) --> MT1-MMP(h) (expression). | fibronectin(h) --> MT1-MMP(h) (increase of abundance) | TNF-alpha(m.s.) --> MT1-MMP(h) (increase of abundance) | MT1-MMP(h) + caveolin-1(mo) <==> MT1-MMP(h):caveolin-1(mo) (binding) | MT1-MMP(h) + caveolin-1(mo){pY} <==> MT1-MMP(h):caveolin-1(mo){pY} (binding) | caveolin-1(m.s.) + MT1-MMP(h) <==> caveolin-1(m.s.):MT1-MMP(h) (binding) | MT1-MMP(h) --> Src(m.s.):caveolin-1(mo) (increase of binding) | MMP14(h) --> MT1-MMP(h) (expression). | TGC(h) --MT1-MMP(h)--> TGC-p70(h) + protein remnants (cleavage) | TGC(h) --MT1-MMP(h)--> TGC-p53(h) + protein remnants (cleavage) | TGC(h) --MT1-MMP(h)--> TGC-p32(h) + TGC-p41(h) + protein remnants (cleavage) |
|---|
Post Translational Modification [Top] | |||
There is no record for MMP14 | |||
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr14 |
Promoter: 22374133 - 22376133 | GoldenGate_Methylation_Cancer_Panel_I |
chr14 |
Promoter: 22374133 - 22376133 | GSE27584 |
chr14 |
Promoter: 22374133 - 22376133 | Agilent_014791_44K |