| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 4313 |
Name | MMP2 |
Synonymous | matrix metallopeptidase 2;MMP2;matrix metallopeptidase 2 |
Definition | 72 kDa type IV collagenase|collagenase type IV-A|matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|matrix metalloproteinase-2|matrix metalloproteinase-II|neutrophil gelatinase |
Position | 16q12.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | TSP-1(h) + mmp2(h) <==> TSP-1(h):mmp2(h) (binding) | TSP-2(m) + mmp2(h) <==> TSP-2(m):mmp2(h) (binding) | mmp2(h) --> mmp2-p62(h) + protein remnants (cleavage) | PROC(h) --> mmp2(h) (activation) | MMP2(h) --> mmp2(h) (expression). | p53-isoform1(h) --> mmp2(h) (increase of abundance) | fibronectin(h) --> mmp2(h) (increase of abundance) | IL-17A(h) --> mmp2(h) (increase of abundance) | estradiol --> mmp2(h) (increase of abundance) | mmp2(h) --MT3-MMP(h)--> protein remnants (cleavage) | MMP2(h) --> mmp2(h) (expression). | ADAMTS-1-p87(m.s.) --mmp2(h)--> ADAMTS-1-p65(m.s.) + protein remnants (cleavage) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 573 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 642 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr16 |
Promoter: 54069089 - 54071089 | GoldenGate_Methylation_Cancer_Panel_I |
chr16 |
Promoter: 54069089 - 54071089 | GSE27584 |
chr16 |
Promoter: 54069089 - 54071089 | Agilent_014791_44K |