| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3455 |
Name | IFNAR2 |
Synonymous | interferon (alpha, beta and omega) receptor 2;IFNAR2;interferon (alpha, beta and omega) receptor 2 |
Definition | IFN-R-2|IFN-alpha/beta receptor 2|human interferon alpha/beta receptor|interferon alpha binding protein|interferon alpha/beta receptor 2|interferon-alpha/beta receptor beta chain|type I interferon receptor 2 |
Position | 21q22.11 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IFNAR2(h) + RACK1(h) <==> IFNAR2(h):RACK1(h) (binding) | IFNAR2(h) + Jak1(h) <==> IFNAR2(h):Jak1(h) (binding) | CBP(h) + IFNAR2(h) <==> CBP(h):IFNAR2(h) (binding) | IFNAR2(h) + IRF-9(h) <==> IFNAR2(h):IRF-9(h) (binding) | IFNAR2(h) + p300(h) <==> IFNAR2(h):p300(h) (binding) | IFNAR2(h) + usp18(h) <==> IFNAR2(h):usp18(h) (binding) | usp18(m) + IFNAR2(h) <==> usp18(m):IFNAR2(h) (binding) | IFNAR2(h) + Jak1(h) <==> IFNAR2(h):Jak1(h) (binding) | IFNAR2(h) + PKCbeta(h) <==> IFNAR2(h):PKCbeta(h) (binding) | IFNAR2(h) + IFNalpha2(h) <==> IFNAR2(h):IFNalpha2(h) (binding) | IFNAR2(h) + IFNbeta(h) <==> IFNAR2(h):IFNbeta(h) (binding) | IFNbeta(h) + IFNAR2(h) + IFNAR1(h) <==> IFNbeta(h):IFNAR2(h):IFNAR1(h) (binding) | IFNAR2(h) + IFNalpha2a(h) <==> IFNAR2(h):IFNalpha2a(h) (binding) | IFNAR2(h) + ATP --> IFNAR2(h){pY} + ADP (phosphorylation) | IFNAR2(h) --> IFNAR2(h) (expression). | IFNbeta(m.s.) --/ IFNAR2(h) (decrease of abundance) | IFNAR2-isoform1(h) + CBP(m.s.) <==> IFNAR2-isoform1(h):CBP(m.s.) (binding) | IFNAR2-isoform1(h) + IRF-9(h) <==> IFNAR2-isoform1(h):IRF-9(h) (binding) | IFNAR2-isoform1(h) + p300(m.s.) <==> IFNAR2-isoform1(h):p300(m.s.) (binding) | IFNAR2-isoform1(h) + ATP --> IFNAR2-isoform1(h){pS400} + ADP (phosphorylation) | IFNAR2-isoform1(h) + acetyl-CoA --CBP(h)--> IFNAR2-isoform1(h){aceK399} + CoA (acetylation) | IFNAR2-isoform1(h) + acetyl-CoA --CBP(m.s.)--> IFNAR2-isoform1(h){aceK399} + CoA (acetylation) | IFNAR2-isoform1(h) + acetyl-CoA --p300(m.s.)--> IFNAR2-isoform1(h){aceK399} + CoA (acetylation) | IFNAR2-isoform1(h) + STAT2(m.s.) <==> IFNAR2-isoform1(h):STAT2(m.s.) (binding) | IFNAR2-isoform1(h) + IRF-9(m.s.) <==> IFNAR2-isoform1(h):IRF-9(m.s.) (binding) | IRF-9(h) + STAT2-isoform1(h) + IFNAR2-isoform1(h) <==> IRF-9(h):STAT2-isoform1(h):IFNAR2-isoform1(h) (binding) | IFNAR2-isoform1(h) + STAT2(h) <==> IFNAR2-isoform1(h):STAT2(h) (binding) | IFNAR2-isoform1(h) + STAT2(m.s.){pY} <==> IFNAR2-isoform1(h):STAT2(m.s.){pY} (binding) | STAT4(m) + IFNAR2-isoform1(h) <==> STAT4(m):IFNAR2-isoform1(h) (binding) | IFNAR2(h) --> IFNAR2-isoform1(h) (expression). | IFNAR2(h) --> IFNAR2-isoform2(h) (expression). | IFNAR2(h) --> IFNAR2-isoform3(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 58 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 87 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 116 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 188 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 192 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 400 | Phosphoserine | 15659558 | Phospho.ELM 6.0 | 411 | Phosphotyrosine | 15659558 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr21 |
Promoter: 33522601 - 33524601 | GSE27584 |
chr21 |
Promoter: 33522601 - 33524601 | GSE27584 |
chr21 |
Promoter: 33522601 - 33524601 | GSE27584 |
chr21 |
Promoter: 33522601 - 33524601 | Agilent_014791_44K |