| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3159 |
Name | HMGA1 |
Synonymous | high mobility group AT-hook 1;HMGA1;high mobility group AT-hook 1 |
Definition | HMG-I(Y)|high mobility group protein A1|high mobility group protein HMG-I/HMG-Y|high mobility group protein R|high-mobility group (nonhistone chromosomal) protein isoforms I and Y|nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y |
Position | 6p21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | HMGIY-isoform1(h) --> IGFBP1(h) (DNA binding). | HMGIY-isoform1(h) + ATP --PKCalpha(r)--> HMGIY-isoform1(h){p} + ADP (phosphorylation) | HMGIY-isoform1(h) --> IL2(b) (DNA binding). | HMGIY-isoform1(h) --> Ifnb1(m) (DNA binding; transactivation). | HMGIY-isoform1(h) --> ABCB1(h) (DNA binding). | HMGIY-isoform1(h) + 3 ATP --hipk2(h)--> HMGIY-isoform1(h){pS36}{pT53}{pT78} + 3 ADP (phosphorylation) | HMGIY-isoform1(h) + 3 ATP --Cdk1(m.s.)--> HMGIY-isoform1(h){pS36}{pT53}{pT78} + 3 ADP (phosphorylation) | HMGIY-isoform1(h) + 5 acetyl-CoA --p300(h)--> HMGIY-isoform1(h){aceK15}{aceK65}{aceK67}{aceK71}{aceK74} + 5 CoA (acetylation) | HMGIY-isoform1(h) + 5 acetyl-CoA --p/CAF(m.s.)--> HMGIY-isoform1(h){aceK15}{aceK65}{aceK67}{aceK71}{aceK74} + 5 CoA (acetylation) | HMGIY-isoform1(h) + 5 acetyl-CoA --> HMGIY-isoform1(h){aceK15}{aceK65}{aceK67}{aceK71}{aceK74} + 5 CoA (acetylation) | HMGA1(h) --> HMGIY-isoform1(h) (expression). | HMGIY-isoform2(h) --> IGFBP1(h) (DNA binding). | HMGIY-isoform2(h) + ATF-2-xbb4(h) <==> HMGIY-isoform2(h):ATF-2-xbb4(h) (binding). | HMGIY-isoform2(h) + ATP --PKCalpha(r)--> HMGIY-isoform2(h){p} + ADP (phosphorylation) | HMGIY-isoform2(h) --> IL2(b) (DNA binding). | HMGIY-isoform2(h) + 2 ATP --hipk2(h)--> HMGIY-isoform2(h){pT42}{pT67} + 2 ADP (phosphorylation) | HMGIY-isoform2(h) + 2 ATP --Cdk1(m.s.)--> HMGIY-isoform2(h){pT42}{pT67} + 2 ADP (phosphorylation) | HMGIY-isoform2(h) + 5 acetyl-CoA --p300(h)--> HMGIY-isoform2(h){aceK15}{aceK54}{aceK56}{aceK60}{aceK63} + CoA (acetylation) | HMGIY-isoform2(h) + 5 acetyl-CoA --p/CAF(m.s.)--> HMGIY-isoform2(h){aceK15}{aceK54}{aceK56}{aceK60}{aceK63} + 5 CoA (acetylation) | HMGIY-isoform2(h) + 5 acetyl-CoA --> HMGIY-isoform2(h){aceK15}{aceK54}{aceK56}{aceK60}{aceK63} + 5 CoA (acetylation) | HMGA1(h) --> HMGIY-isoform2(h) (expression). | HMGIY(h) --> CXCL1(h) (DNA binding). | HMGIY(h) --/ Il4(m) (DNA binding; transrepression). | HMGIY(h) --> HPV-18(HPV) (DNA binding; transactivation). | JunB(h) + HMGIY(h) <==> HMGIY(h):JunB(h) (assembly; binding; interaction) | Fra-2(h) + HMGIY(h) <==> HMGIY(h):Fra-2(h) (interaction; assembly; binding) | HMGIY(h) --> IFNB1(h) (DNA binding; transactivation). | HMGIY(h) --> IL-2Ralpha(h) (DNA binding; transactivation). | HMGIY(h) --> CD44(m) (DNA binding; transactivation). | HMGIY(h) --> INSR(h) (DNA binding). | SPI1(m.s.) + HMGIY(h) <==> SPI1(m.s.):HMGIY(h) (binding) | HMGIY(h) --> HLA-DRA(h) (DNA binding). | AP-2alpha(h) + HMGIY(h) <==> AP-2alpha(h):HMGIY(h) (binding) | EWS(h) + HMGIY(h) <==> EWS(h):HMGIY(h) (binding) | HMGA1(h) --> HMGIY(h) (expression). | HMGA1(h) --> HMGIY-isoform3(h) (expression). | HMGA1(h) --> HMGA1_01(h) (expression). | hsa-miR-103 --/ HMGA1_01(h) (predicted) | hsa-miR-107 --/ HMGA1_01(h) (predicted) | HMGA1(h) --> HMGA1_02(h) (expression). | hsa-miR-103 --/ HMGA1_02(h) (predicted) | hsa-miR-107 --/ HMGA1_02(h) (predicted) | HMGA1(h) --> HMGA1_03(h) (expression). | hsa-miR-103 --/ HMGA1_03(h) (predicted) | hsa-miR-107 --/ HMGA1_03(h) (predicted) | HMGA1(h) --> HMGA1_04(h) (expression). | hsa-miR-103 --/ HMGA1_04(h) (predicted) | hsa-miR-107 --/ HMGA1_04(h) (predicted) | HMGA1(h) --> HMGA1_05(h) (expression). | hsa-miR-103 --/ HMGA1_05(h) (predicted) | hsa-miR-107 --/ HMGA1_05(h) (predicted) | HMGA1(h) --> HMGA1_06(h) (expression). | hsa-miR-103 --/ HMGA1_06(h) (predicted) | hsa-miR-107 --/ HMGA1_06(h) (predicted) | HMGA1(h) --> HMGA1_07(h) (expression). | hsa-miR-103 --/ HMGA1_07(h) (predicted) | hsa-miR-107 --/ HMGA1_07(h) (predicted) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 2 | N-acetylserine (By similarity). | Swiss-Prot 53.0 | 26 | Asymmetric dimethylarginine; in isoformHMG-I; alternate. | Swiss-Prot 53.0 | 26 | Omega-N-methylarginine; in isoform HMG-I;alternate. | Swiss-Prot 53.0 | 26 | Symmetric dimethylarginine; in isoformHMG-I; alternate. | Swiss-Prot 53.0 | 36 | Phosphoserine. | Swiss-Prot 53.0 | 49 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 53 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 99 | Phosphoserine; in isoform HMG-I andisoform HMG-Y. | Swiss-Prot 53.0 | 102 | Phosphoserine; by CK; in isoform HMG-Iand isoform HMG-Y. | Swiss-Prot 53.0 | 103 | Phosphoserine; by CK; in isoform HMG-Iand isoform HMG-Y. | Swiss-Prot 53.0 | 52 | Phosphothreonine (CDK1) | 1939057;15302935 | Phospho.ELM 6.0 | 77 | Phosphothreonine (CDK1) | 1939057;15302935 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr6 |
Promoter: 34311128 - 34313128 | Agilent_014791 |
chr6 |
Promoter: 34311407 - 34313407 | Agilent_014791 |
chr6 |
Promoter: 34311874 - 34313874 | Agilent_014791 |
chr6 |
Promoter: 34313046 - 34315046 | Agilent_014791 |
chr6 |
Promoter: 34311128 - 34313128 | GSE27584 |
chr6 |
Promoter: 34311128 - 34313128 | GSE27584 |
chr6 |
Promoter: 34313046 - 34315046 | GSE27584 |
chr6 |
Promoter: 34311407 - 34313407 | GSE27584 |
chr6 |
Promoter: 34311407 - 34313407 | GSE27584 |
chr6 |
Promoter: 34311128 - 34313128 | GSE27584 |