| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 3064 |
Name | HTT |
Synonymous | huntingtin;HTT;huntingtin |
Definition | huntington disease protein |
Position | 4p16.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | huntingtin(h) + Hip-1(h) <==> huntingtin(h):Hip-1(h) (binding) | huntingtin(h) + hap1(h) <==> huntingtin(h):hap1(h) (binding) | MLK2(h) + huntingtin(h) <==> MLK2(h):huntingtin(h) (binding) | huntingtin(h) --Caspase-3(h)--> huntingtin-p80(h) + huntingtin-p67(h) (processing) | huntingtin(h) --Caspase-1(h)--> huntingtin-p67(h) + huntingtin-p52(h) (processing) | huntingtin(h) + REST(h) <==> huntingtin(h):REST(h) (binding) | huntingtin(h) + Sp1(h) <==> huntingtin(h):Sp1(h) (binding) | huntingtin(h) + TAF(II)135(h) <==> huntingtin(h):TAF(II)135(h) (binding) | huntingtin(h) + CtIP(h) <==> huntingtin(h):CtIP(h) (binding) | huntingtin(h) + CBP(h) <==> huntingtin(h):CBP(h) (binding) | huntingtin(h) + p/CAF(h) <==> huntingtin(h):p/CAF(h) (binding) | huntingtin(h) + EGFR(h) <==> huntingtin(h):EGFR(h) (binding) | huntingtin(h) + Grb-2(h) <==> huntingtin(h):Grb-2(h) (binding) | huntingtin(h) + Shc-1-p52(h) <==> huntingtin(h):Shc-1-p52(h) (binding) | huntingtin(h) + Shc-1-p46(h) <==> huntingtin(h):Shc-1-p46(h) (binding) | huntingtin(h) + RasGAP(h) <==> huntingtin(h):RasGAP(h) (binding) | huntingtin(h) + K08E3.3b(ce) <==> huntingtin(h):K08E3.3b(ce) (binding) | huntingtin(h) + CIP4(h) <==> huntingtin(h):CIP4(h) (binding) | huntingtin(h) + ATP --SGK-1(h)--> huntingtin(h){pS421} + ADP (phosphorylation) | huntingtin(h) + ATP --SGK-1(r)--> huntingtin(h){pS421} + ADP (phosphorylation) | huntingtin(h) + ATP --AKT-1(m)--> huntingtin(h){pS421} + ADP (phosphorylation) | HIP2(h) + huntingtin(h) <==> HIP2(h):huntingtin(h) (binding) | huntingtin(h) + NCOR1(r) <==> huntingtin(h):NCOR1(r) (binding) | huntingtin(h) + HIP14(h) <==> huntingtin(h):HIP14(h) (binding) | huntingtin(h) + CA150(h) <==> huntingtin(h):CA150(h) (binding) | huntingtin(h) --calpain-2(rb)--> huntingtin-p67(h) + protein remnants (processing) | huntingtin(h) + PSD-95(h) <==> huntingtin(h):PSD-95(h) (binding) | huntingtin(h) + NR1-isoform3(h) <==> huntingtin(h):NR1-isoform3(h) (binding) | huntingtin(h) + NR2B(h) <==> huntingtin(h):NR2B(h) (binding) | huntingtin(h) + GluR6(h) <==> huntingtin(h):GluR6(h) (binding) | huntingtin(h) + NR2A(h) <==> huntingtin(h):NR2A(h) (binding) | huntingtin(h) --calpain-1(h)--> huntingtin-p47(h) + huntingtin-p62(h) (processing) | huntingtin(h) --calpain-2(rb)--> huntingtin-p47(h) + huntingtin-p62(h) + huntingtin-p67(h) (processing) | huntingtin(h) --Caspase-3(h)--> huntingtin-p70(h) (processing) | huntingtin(h) --Caspase-6(h)--> huntingtin-p80(h) (processing) | huntingtin(h) --Caspase-2(h)--> huntingtin-p75(h) + protein remnants (processing) | IP3R1(r):hap1a(r) + huntingtin(h) <==> IP3R1(r):hap1a(r):huntingtin(h) (binding) | huntingtin(h) + sumo1(h) --> huntingtin(h){sumo} (sumoylation) | huntingtin(h) + ubiquitin(h) --> huntingtin(h){ub} (ubiquitination) | huntingtin(h) + Cat-1(h) <==> huntingtin(h):Cat-1(h) (binding) | HTT(h) --> huntingtin(h) (expression). | huntingtin(h) --> ADORA2A(r) (DNA binding; transactivation). | HTT(h) --> huntingtin(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 421 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1876 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 434 | Phosphoserine | 15911879 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr4 |
Promoter: 3044706 - 3046706 | GSE27584 |
chr4 |
Promoter: 3044706 - 3046706 | Agilent_014791_44K |