| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 27 |
Name | ABL2 |
Synonymous | ABL proto-oncogene 2, non-receptor tyrosine kinase;ABL2;ABL proto-oncogene 2, non-receptor tyrosine kinase |
Definition | Abelson tyrosine-protein kinase 2|abelson-related gene protein|c-abl oncogene 2, non-receptor tyrosine kinase|tyrosine-protein kinase ARG|v-abl Abelson murine leukemia viral oncogene homolog 2 |
Position | 1q25.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ABL2(h) --> ARG-1c(h) (expression). | ARG(h) + ABL-1b(h){pY} <==> ARG(h):ABL-1b(h){pY} (binding) | ARG(h) + bcr(h) <==> ARG(h):bcr(h) (binding) | ErbB1-p170(h){pY915}{pY1016}{pY1110}{pY1125}{pY1138}{pY1172}{pY1197} + ARG(h) <==> ARG(h):ErbB1-p170(h){pY915}{pY1016}{pY1110}{pY1125}{pY1138}{pY1172}{pY1197} (binding) | ErbB2(h){pY1139}{pY1196}{pY1221}{pY1222}{pY1248} + ARG(h) <==> ErbB2(h){pY1139}{pY1196}{pY1221}{pY1222}{pY1248}:ARG(h) (binding) | ErbB3-isoform1(h){pY868}{pY1054}{pY1222}{pY1224}{pY1260}{pY1262}{pY1276}{pY1289} + ARG(h) <==> ErbB3-isoform1(h){pY868}{pY1054}{pY1222}{pY1224}{pY1260}{pY1262}{pY1276}{pY1289}:ARG(h) (binding) | ErbB4(h){pY1162}{pY1188}{pY1258}{pY1284} + ARG(h) <==> ErbB4(h){pY1162}{pY1188}{pY1258}{pY1284}:ARG(h) (binding) | ABL2(h) --> ARG(h) (expression). | ABL2(h) --> ARG-1B(h) (expression). | ABL2(h) --> ARG-1A(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 2 | N-myristoyl glycine (By similarity). | Swiss-Prot 53.0 | 203 | Phosphoserine. | Swiss-Prot 53.0 | 231 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 272 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 299 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 303 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 310 | Phosphotyrosine. | Swiss-Prot 53.0 | 439 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 440 | Phosphothreonine. | Swiss-Prot 53.0 | 492 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 515 | Phosphotyrosine. | Swiss-Prot 53.0 | 631 | Phosphoserine. | Swiss-Prot 53.0 | 783 | Phosphoserine. | Swiss-Prot 53.0 | 817 | Phosphoserine. | Swiss-Prot 53.0 | 936 | Phosphoserine. | Swiss-Prot 53.0 | 310 | Phosphotyrosine | 12522270 | Phospho.ELM 6.0 | 439 | Phosphotyrosine | 12522270 | Phospho.ELM 6.0 | 440 | Phosphothreonine | 12522270 | Phospho.ELM 6.0 | 515 | Phosphotyrosine | 12522270 | Phospho.ELM 6.0 | 261 | Phosphotyrosine | 15735735 | Phospho.ELM 6.0 | 200 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 631 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 177464859 - 177466859 | Agilent_014791 |
chr1 |
Promoter: 177464859 - 177466859 | GoldenGate_Methylation_Cancer_Panel_I |
chr1 |
Promoter: 177464859 - 177466859 | GSE27584 |