| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2688 |
Name | GH1 |
Synonymous | growth hormone 1;GH1;growth hormone 1 |
Definition | pituitary growth hormone|somatotropin |
Position | 17q24.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | GH(h) + prlr(r) <==> GH(h):(prlr(r))2 (binding) | GH(h) --> ERK2(m){p} (increase of phosphorylation) | GH(h) --> Jak2(m){pY} (increase of phosphorylation) | GH(h) --> GHR(m){pY} (increase of phosphorylation) | GH(h) --> Jak2(m){pY}:GHR(m){pY}:IGF-1R(m) (increase of binding) | GH(h) --> IGF-1R(m){pY} (increase of phosphorylation) | GH(h) --> EGFR(m){pY} (increase of phosphorylation) | GH(h) --> AKT(m) (increase of phosphorylation) | GH(h) --> ERK1(m){p} (increase of phosphorylation) | GH(h) --> Jak2(h){pY}:GHR(h) (assembly) | GH(h) --> GHR(h){pY} (increase of phosphorylation) | GH(h) --> Jak2(h){pY}:GHR(h){pY} (increase of binding) | GH(h) + GHR(rb) <==> GH(h):GHR(rb) (binding) | GH(h) --> Jak2(m){pY}:GHR(rb) (increase of binding) | GH(h) --> Jak2(h){pY} (increase of phosphorylation) | GH(h) --> Cas(ha){pY} (increase of phosphorylation) | GH(h) --> crk(ha){pY} (increase of phosphorylation) | GH(h) --> Src(ha){pY} (increase of phosphorylation) | GH(h) --> Fyn(ha){pY} (increase of phosphorylation) | GH(h) --> c-Cbl(ha){pY} (increase of phosphorylation) | GH(h) --> Nck-1(ha){pY} (increase of phosphorylation) | GH(h) --> Cas(ha){pY}:crk(ha){pY} (increase of binding) | GH(h) --> crk(ha){pY}:FAK(ha) (increase of binding) | GH(h) --> c-Cbl(ha){pY}:crk(ha){pY} (increase of binding) | GH(h) --> c-Cbl(ha){pY}:Src(ha){pY} (increase of binding) | GH(h) --> c-Cbl(ha){pY}:Fyn(ha){pY} (increase of binding) | GH(h) --> Nck-1(ha){pY}:crk(ha){pY} (increase of binding) | GH(h) --> C3G(ha):crk(ha){pY} (increase of binding) | GH(h) --> Shc-1(ha):crk(ha){pY} (increase of binding) | GH(h) --> Grb-2(ha):crk(ha){pY} (increase of binding) | GH(h) --> crk(ha){pY}:Sos1(ha) (increase of binding) | GH(h) --> TENS1(ha):crk(ha){pY} (increase of binding) | GH(h) --> crk(ha){pY}:paxillin(ha) (increase of binding) | GH(h) --> p85alpha(ha):crk(ha){pY} (increase of binding) | GH(h) --> FAK(ha):Src(ha){pY} (increase of binding) | GH(h) --> Cas(ha){pY}:Src(ha){pY} (increase of binding) | GH(h) --> crk(ha){pY}:Fyn(ha){pY} (increase of binding) | GH(h) --> c-Jun(m.s.){pS63} (increase of phosphorylation) | GH(h) --> C/EBPbeta(m){aceK39} (increase of acetylation) | GH(h) --> AKT(m){p} (increase of phosphorylation) | GH(h) --> FOXO3a(m){pT32} (increase of phosphorylation) | GH(h) --> PRLR-S(r){pY} (increase of phosphorylation) | GH(h) --> PRLR-L(r){pY} (increase of phosphorylation) | GH(h) --> Jak2(r){pY} (increase of phosphorylation) | GH(h) + leukotriene A-4 hydrolase(h) <==> GH(h):leukotriene A-4 hydrolase(h) (binding) | GH(h) + SIP(h) <==> GH(h):SIP(h) (binding) | GH(h) + STRAP(h) <==> GH(h):STRAP(h) (binding) | GH(h) --> ERK1(ha){pT183} (increase of phosphorylation) | GH(h) --> ERK2(ha){pY185} (increase of phosphorylation) | GH(h) --> STAT5(h):GHR(h) (increase of binding) | GH(h) --> Jak2(m){pS523}{pY570}{pY1007} (increase of phosphorylation) | GH(h) --> ERK1(m){pT203} (increase of phosphorylation) | GH(h) --> ERK2(m){pY185} (increase of phosphorylation) | GH(h) --> STAT5B(m){p} (increase of phosphorylation) | GH1(h) --> GH(h) (expression). | calcitriol:VDR(h) --> GH(h) (increase of secretion) | collectrin(h) --> GH(h) (increase of secretion) | Gem(h) --> GH(h) (decrease of secretion) | GH1(h) --> GH-isoform1(h) (expression). | GH1(h) --> GH-isoform2(h) (expression). | GH1(h) --> GH-isoform3(h) (expression). | GH1(h) --> GH-isoform4(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 132 | Phosphoserine. | Swiss-Prot 53.0 | 163 | Deamidated glutamine. | Swiss-Prot 53.0 | 176 | Phosphoserine. | Swiss-Prot 53.0 | 178 | Deamidated asparagine. | Swiss-Prot 53.0 | 132 | Phosphoserine | 14997482 | Phospho.ELM 6.0 | 176 | Phosphoserine | 14997482 | Phospho.ELM 6.0 | 77 | Phosphoserine | 15717326 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 59349430 - 59351430 | GSE27584 |
chr17 |
Promoter: 59349430 - 59351430 | GSE27584 |
chr17 |
Promoter: 59349430 - 59351430 | GSE27584 |
chr17 |
Promoter: 59349430 - 59351430 | GSE27584 |
chr17 |
Promoter: 59349430 - 59351430 | GSE27584 |