Entrez Gene

Basic Information
Gene ID	267
Name	AMFR
Synonymous	autocrine motility factor receptor, E3 ubiquitin protein ligase;AMFR;autocrine motility factor receptor, E3 ubiquitin protein ligase
Definition	E3 ubiquitin-protein ligase AMFR\|RING finger protein 45
Position	16q21
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
AMFR(h) --> Gp78-isoform1(h) (expression).
2 Gp78(h) <==> (Gp78(h))2 (oligomerization)
vcp(h) + Gp78(h) <==> vcp(h):Gp78(h) (binding)
Hsp60(h) + Gp78(h) <==> Hsp60(h):Gp78(h) (binding)
Ufd1(h) + Gp78(h) <==> Ufd1(h):Gp78(h) (binding)
rpl5(h) + Gp78(h) <==> rpl5(h):Gp78(h) (binding)
UBE2G2(h) + Gp78(h) <==> UBE2G2(h):Gp78(h) (binding)
vcp(h) + svip(h) + Derl1(h) + Gp78(h) + HRD1(h) + Ufd1(h) + NPL4(h) <==> vcp(h):svip(h):Derl1(h):Gp78(h):HRD1(h):Ufd1(h):NPL4(h) (binding)
Gp78(h) + Derl1(h) + vcp(h) + SELS(h) <==> Gp78(h):Derl1(h):vcp(h):SELS(h) (binding)
Gp78(h) + Derl1(h) <==> Gp78(h):Derl1(h) (binding)
Derl1(h) + vcp(h) + Gp78(h) <==> Derl1(h):vcp(h):Gp78(h) (binding)
AMFR(h) --> Gp78(h) (expression).
3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) + n ubiquitin(h) --Gp78(h)--> 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h){ub}n (ubiquitination)
UBE2G2(m) + n ubiquitin(m) --E1(m.s.),UBE2G2(m),Gp78(h)--> UBE2G2(m){ub(n)C89} (ubiquitination)
Herp(h) + n ubiquitin(h) --E1(m.s.),UBE2G2(m),Gp78(h)--> Herp(h){ub(n)K61} (ubiquitination)
UBE2G2(m) + ubiquitin(m) --E1(m.s.),UBE2G2(m),Gp78(h)--> UBE2G2(m){ubC89} (ubiquitination)
UBE2G2(m) + 2 ubiquitin(m) --E1(m.s.),UBE2G2(m),Gp78(h)--> UBE2G2(m){ub(2)C89} (ubiquitination)
UBE2G2(m) + 3 ubiquitin(m) --E1(m.s.),UBE2G2(m),Gp78(h)--> UBE2G2(m){ub(3)C89} (ubiquitination)
UBE2G2(m) + 4 ubiquitin(m) --E1(m.s.),UBE2G2(m),Gp78(h)--> UBE2G2(m){ub(4)C89} (ubiquitination)
UBE2G2(m) + 5 ubiquitin(m) --E1(m.s.),UBE2G2(m),Gp78(h)--> UBE2G2(m){ub(5)C89} (ubiquitination)
2 UBE2G2(m){ubC89} --Gp78(h)--> UBE2G2(m){ub(2)C89} + UBE2G2(m) (ubiquitination)
Herp(h) + ubiquitin(h) --E1(m.s.),UBE2G2(m),Gp78(h)--> Herp(h){ubK61} (ubiquitination)
Herp(h) + 2 ubiquitin(h) --E1(m.s.),UBE2G2(m),Gp78(h)--> Herp(h){ub(2)K61} (ubiquitination)
Herp(h) + 3 ubiquitin(h) --E1(m.s.),UBE2G2(m),Gp78(h)--> Herp(h){ub(3)K61} (ubiquitination)
Herp(h) + 4 ubiquitin(h) --E1(m.s.),UBE2G2(m),Gp78(h)--> Herp(h){ub(4)K61} (ubiquitination)
Gp78-isoform2(h) + insig-1(h) <==> Gp78-isoform2(h):insig-1(h) (binding)
Gp78-isoform2(h) + insig-1(h) + 3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) <==> Gp78-isoform2(h):insig-1(h):3-hydroxy-3-methylglutaryl-coenzyme A reductase(h) (binding)
vcp(h) + Gp78-isoform2(h) + insig-1(h) <==> vcp(h):Gp78-isoform2(h):insig-1(h) (binding)
Ufd1(h) + Gp78-isoform2(h) <==> Ufd1(h):Gp78-isoform2(h) (binding)
Gp78-isoform2(h) + Ufd1-S(h) <==> Gp78-isoform2(h):Ufd1-S(h) (binding)
Gp78-isoform2(h) + UBE2G2(h) <==> Gp78-isoform2(h):UBE2G2(h) (binding)
Gp78-isoform2(h) + ubiquitin(h) <==> Gp78-isoform2(h):ubiquitin(h) (binding)
AMFR(h) --> Gp78-isoform2(h) (expression).
3-hydroxy-3-methylglutaryl-coenzyme A reductase(gl) + ubiquitin(h) --UBE2G2(h),E1(h),Gp78-isoform2(h)--> 3-hydroxy-3-methylglutaryl-coenzyme A reductase(gl){ub} (ubiquitination)
Herp(h) + ubiquitin(h) --Gp78-isoform2(h),UBE2G2(h),E1(h)--> Herp(h){ub} (ubiquitination)
Herp(h) + 2 ubiquitin(h) --E1(h),UBE2G2(h),Gp78-isoform2(h)--> Herp(h){ub}2 (ubiquitination)
ubiquitin(h) + Herp(h) --Gp78-isoform2(h),UBE2G2(h),E1(h)--> Herp(h){ub}n (ubiquitination)

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
542	Phosphoserine (By similarity).		Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr16	Promoter: 55016445 - 55018445	Agilent_014791
chr16	Promoter: 55016445 - 55018445	GSE27584
chr16	Promoter: 55016445 - 55018445	Agilent_014791_44K

Transcription Factors [Top]

Post Translational Modification [Top]

Methylation Profile [Top]