| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2241 |
Name | FER |
Synonymous | fer (fps/fes related) tyrosine kinase;FER;fer (fps/fes related) tyrosine kinase |
Definition | feline encephalitis virus-related kinase FER|fujinami poultry sarcoma/Feline sarcoma-related protein Fer|phosphoprotein NCP94|protein phosphatase 1, regulatory subunit 74|proto-oncogene c-Fer|tyrosine kinase 3|tyrosine-protein kinase Fer |
Position | 5q21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Yes(r) + p120CAS(m){pY} + E-cadherin(m) + Fyn(r) + fer(h) <==> E-cadherin(m):fer(h):Fyn(r):p120CAS(m){pY}:Yes(r) (binding) | p120CAS(r) + fer(h) <==> fer(h):p120CAS(r) (binding) | beta-catenin(r) + fer(h) <==> beta-catenin(r):fer(h) (binding) | p120CAS(h){pY} + fer(h) <==> fer(h):p120CAS(h){pY} (binding) | EGFR(h) + fer(h) <==> EGFR(h):fer(h) (binding) | cortactin(m) + fer(h) <==> cortactin(m):fer(h) (binding) | FER(h) --> fer(h) (expression). | beta-catenin(m) + ATP --fer(h)--> beta-catenin(m){pY142} + ADP (phosphorylation) | plakoglobin(h) + ATP --fer(h)--> plakoglobin(h){pY549} + ADP (phosphorylation) | ErbB1-p170(h) + fer(h) <==> ErbB1-p170(h):fer(h) (binding) | ErbB2(h) + fer(h) <==> ErbB2(h):fer(h) (binding) | ErbB3-isoform1(h){pY1289} + fer(h) <==> ErbB3-isoform1(h){pY1289}:fer(h) (binding) | ErbB4(h) + fer(h) <==> ErbB4(h):fer(h) (binding) | FER(h) --> fer(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 402 | Phosphotyrosine. | Swiss-Prot 53.0 | 434 | Phosphoserine. | Swiss-Prot 53.0 | 714 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 714 | Phosphotyrosine | 10998246 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr5 |
Promoter: 108109922 - 108111922 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 108109922 - 108111922 | GSE27584 |
chr5 |
Promoter: 108109922 - 108111922 | Agilent_014791_44K |