| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2185 |
Name | PTK2B |
Synonymous | protein tyrosine kinase 2 beta;PTK2B;protein tyrosine kinase 2 beta |
Definition | CAK-beta|FADK 2|PTK2B protein tyrosine kinase 2 beta|calcium-dependent tyrosine kinase|calcium-regulated non-receptor proline-rich tyrosine kinase|cell adhesion kinase beta|focal adhesion kinase 2|proline-rich tyrosine kinase 2|protein kinase B|protein-ty |
Position | 8p21.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Pyk2-isoform1(h) + paxillin(h) <==> Pyk2-isoform1(h):paxillin(h) (binding) | Grb-2(h) + Pyk2-isoform1(h) <==> Grb-2(h):Pyk2-isoform1(h) (binding) | Pyk2-isoform1(h) + Hic-5(h) <==> Pyk2-isoform1(h):Hic-5(h) (binding) | Pyk2-isoform1(h) + ATP --> Pyk2-isoform1(h){p} + ADP (phosphorylation) | Cas(h) + Pyk2-isoform1(h) <==> Pyk2-isoform1(h):Cas(h) (binding) | Pyk2-isoform1(h) + leupaxin(h) <==> Pyk2-isoform1(h):leupaxin(h) (binding) | Pyk2-isoform1(h) + Graf2(h) <==> Pyk2-isoform1(h):Graf2(h) (binding) | Pyk2-isoform1(h) + DDEF2alpha(h) <==> Pyk2-isoform1(h):DDEF2alpha(h) (binding) | Pyk2-isoform1(h) + DDEF2beta(m) <==> Pyk2-isoform1(h):DDEF2beta(m) (binding) | ErbB1(h) + Pyk2-isoform1(h) <==> ErbB1(h):Pyk2-isoform1(h) (binding) | Src(h) + Pyk2-isoform1(h) <==> Src(h):Pyk2-isoform1(h) (binding) | Pyk2-isoform1(h) + STAT3(h) <==> Pyk2-isoform1(h):STAT3(h) (binding) | Pyk2-isoform1(h) + ATP --> Pyk2-isoform1(h){pY881} + ADP (phosphorylation) | PSD-95alpha(r) + Pyk2-isoform1(h) <==> PSD-95alpha(r):Pyk2-isoform1(h) (binding) | SAP102(r) + Pyk2-isoform1(h) <==> SAP102(r):Pyk2-isoform1(h) (binding) | PTK2B(h) --> Pyk2-isoform1(h) (expression). | Pyk2-isoform1(h):Hic-5(h) + NTP --> Pyk2-isoform1(h) + Hic-5(h){p} + NDP (phosphorylation; dissociation) | beta1-integrin(h) --> Pyk2-isoform1(h) (activation; phosphorylation) | BCR(h) --> Pyk2-isoform1(h) (activation; phosphorylation) | RANTES(h) --> Pyk2-isoform2(h) (activation; phosphorylation) | MIP1B(h) --> Pyk2-isoform2(h) (activation; phosphorylation) | PTK2B(h) --> Pyk2-isoform2(h) (expression). | Alix(m.s.) + Pyk2(h) <==> Alix(m.s.):Pyk2(h) (binding) | Pyk2(h) + 2 ATP --> Pyk2(h){pY402}{pY881} + 2 ADP (phosphorylation) | Pyk2(h) --> Prap(h){pY} (increase of phosphorylation) | Prap(h) + Pyk2(h) <==> Prap(h):Pyk2(h) (binding) | Pyk2(h) --> NACP(h){pY} (increase of phosphorylation) | Pyk2(h) --> Src(h){pY} (increase of phosphorylation) | Hic-5(m.s.) + Pyk2(h) <==> Hic-5(m.s.):Pyk2(h) (binding) | SHP-1(h) + Pyk2(h) <==> SHP-1(h):Pyk2(h) (binding) | MEKK4(h) + Pyk2(h) <==> MEKK4(h):Pyk2(h) (binding) | Pyk2(h) + ATP --> Pyk2(h){pY} + ADP (phosphorylation) | HEF1(h) + Pyk2(h) <==> HEF1(h):Pyk2(h) (binding) | Cas(h) + Pyk2(h) <==> Cas(h):Pyk2(h) (binding) | ErbB1(h) + Pyk2(h) <==> ErbB1(h):Pyk2(h) (binding) | Pyk2(h) + Src(h) <==> Pyk2(h):Src(h) (binding) | Pyk2(h) + p190RhoGAP(h) <==> Pyk2(h):p190RhoGAP(h) (binding) | Pyk2(h) + RasGAP(h) <==> Pyk2(h):RasGAP(h) (binding) | Pyk2(h) + p190RhoGAP(r) <==> Pyk2(h):p190RhoGAP(r) (binding) | Pyk2(h) + ErbB2(h) <==> Pyk2(h):ErbB2(h) (binding) | Pyk2(h) + ATP --> Pyk2(h){pY881} + ADP (phosphorylation) | PTK2B(h) --> Pyk2(h) (expression). | Pyk2(h){pY} --SHP-2(h)--> p + Pyk2(h) (dephosphorylation) | MEKK4(h) + ATP --Pyk2(h)--> MEKK4(h){pY} + ADP (phosphorylation) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 375 | Phosphoserine. | Swiss-Prot 53.0 | 402 | Phosphotyrosine. | Swiss-Prot 53.0 | 579 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 580 | Phosphotyrosine. | Swiss-Prot 53.0 | 881 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 402 | Phosphotyrosine (Syk;PYK2) | 8816475;9560226;15105428 | Phospho.ELM 6.0 | 881 | Phosphotyrosine | 10880513 | Phospho.ELM 6.0 | 579 | Phosphotyrosine | 10704819;10085136;12522270 | Phospho.ELM 6.0 | 580 | Phosphotyrosine | 10704819;10085136;12522270 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr8 |
Promoter: 27237498 - 27239498 | Agilent_014791 |
chr8 |
Promoter: 27223416 - 27225416 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 27223416 - 27225416 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 27223416 - 27225416 | GSE27584 |
chr8 |
Promoter: 27223416 - 27225416 | GSE27584 |
chr8 |
Promoter: 27237498 - 27239498 | GSE27584 |
chr8 |
Promoter: 27237471 - 27239471 | GSE27584 |
chr8 |
Promoter: 27223416 - 27225416 | Agilent_014791_44K |
chr8 |
Promoter: 27237498 - 27239498 | Agilent_014791_44K |