| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2147 |
Name | F2 |
Synonymous | coagulation factor II (thrombin);F2;coagulation factor II (thrombin) |
Definition | prepro-coagulation factor II|prothrombin|prothrombin B-chain|serine protease |
Position | 11p11 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | thrombin(h) --> WASP(h){pY} (increase of phosphorylation) | thrombin(h) --> LAT(h){p} (increase of phosphorylation) | thrombin(h) --> Syk(h){pY525}{pY526} (increase of phosphorylation) | thrombin(h) --> ICAM1(h) (transactivation) | thrombin(h) --> icam1(h) (increase of abundance) | thrombin(h) --> RelA-p65(h){pS536}{pY} (increase of phosphorylation) | thrombin(h) --> RelA-p65(h):Syk(h) (increase of binding) | thrombin(h) --> Src(h){pY419} (increase of phosphorylation) | F2(h) --> thrombin(h) (expression). | GP6(h) --> thrombin(h) (increase of secretion) | F2(h) --> thrombin(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 49 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 50 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 57 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 59 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 62 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 63 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 68 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 69 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 72 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 75 | 4-carboxyglutamate. | Swiss-Prot 53.0 | 121 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 143 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 416 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for F2 | ||