Entrez Gene

Basic Information
Gene ID	208
Name	AKT2
Synonymous	v-akt murine thymoma viral oncogene homolog 2;AKT2;v-akt murine thymoma viral oncogene homolog 2
Definition	PKB beta\|RAC-PK-beta\|RAC-beta serine/threonine-protein kinase\|murine thymoma viral (v-akt) homolog-2\|protein kinase Akt-2\|protein kinase B beta\|rac protein kinase beta
Position	19q13.1-q13.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
AKT-2(h) + XIAP(h) <==> AKT-2(h):XIAP(h) (binding)
AKT-2(h) + ATP --> AKT-2(h){pS474} + ADP (phosphorylation)
AKT2(h) --> AKT-2(h) (expression).
XIAP(h) + NTP --AKT-2(h)--> XIAP(h){pS87} + NDP (phosphorylation)
AKT-2(h) --Caspase-3(h)--> AKT-2-p51(h) + protein remnants (cleavage)
AKT-2(h) + ATP --> AKT-2(h){pS474} + ADP (phosphorylation)
AKT-2(h) + APPL(m.s.) <==> AKT-2(h):APPL(m.s.) (binding)
AKT2(h) --> AKT-2(h) (expression).
ERR1(h) + ATP --AKT-2(h)--> ERR1(h){p} + ADP (phosphorylation)

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
309	Phosphothreonine (by PDPK1).		Swiss-Prot 53.0
474	Phosphoserine.		Swiss-Prot 53.0
309	Phosphothreonine (PDK-1)	9512493	Phospho.ELM 6.0
126	Phosphoserine	9374542	Phospho.ELM 6.0
451	Phosphothreonine	9374542	Phospho.ELM 6.0
474	Phosphoserine	9374542;10822383	Phospho.ELM 6.0

Transcription Factors [Top]