| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 2017 |
Name | CTTN |
Synonymous | cortactin;CTTN;cortactin |
Definition | 1110020L01Rik|amplaxin|ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)|oncogene EMS1|src substrate cortactin |
Position | 11q13 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | cortactin(h) + N-WASP(h) <==> cortactin(h):N-WASP(h) (binding) | cortactin(h) + ATP --fer(h){pY591}--> cortactin(h){pY} + ADP (phosphorylation) | cortactin(h) + ATP --> cortactin(h){pS405}{pS418} + ADP (phosphorylation) | cortactin(h) + cd2ap(h) <==> cd2ap(h):cortactin(h) (binding) | EGFR(h) + cortactin(h) + cd2ap(h) <==> cd2ap(h):cortactin(h):EGFR(h) (binding) | cortactin(h) + WIP(h) <==> cortactin(h):WIP(h) (binding) | cortactin(h) + Rac1(h) <==> cortactin(h):Rac1(h) (binding) | CTTN(h) --> cortactin(h) (expression). | CTTN(h) --> cortactin(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 215 | Phosphotyrosine. | Swiss-Prot 53.0 | 334 | Phosphotyrosine. | Swiss-Prot 53.0 | 401 | Phosphothreonine. | Swiss-Prot 53.0 | 405 | Phosphoserine. | Swiss-Prot 53.0 | 418 | Phosphoserine. | Swiss-Prot 53.0 | 421 | Phosphotyrosine. | Swiss-Prot 53.0 | 446 | Phosphotyrosine. | Swiss-Prot 53.0 | 453 | Phosphotyrosine. | Swiss-Prot 53.0 | 421 | Phosphotyrosine (Src) | 12522270;9748248;15169891 | Phospho.ELM 6.0 | 470 | Phosphotyrosine (Src) | 9748248 | Phospho.ELM 6.0 | 486 | Phosphotyrosine (Src) | 9748248 | Phospho.ELM 6.0 | 405 | Phosphoserine (MAP2K1;MAP2K) | 10537323;15144186;17081983 | Phospho.ELM 6.0 | 418 | Phosphoserine (MAP2K1;MAP2K) | 10537323;17081983 | Phospho.ELM 6.0 | 401 | Phosphothreonine | 15302935;15144186;17081983 | Phospho.ELM 6.0 | 446 | Phosphotyrosine (FGFR1) | 12601080;15592455 | Phospho.ELM 6.0 | 453 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 69920792 - 69922792 | Agilent_014791 |
chr11 |
Promoter: 69920792 - 69922792 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 69920792 - 69922792 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 69920792 - 69922792 | GSE27584 |
chr11 |
Promoter: 69920792 - 69922792 | GSE27584 |
chr11 |
Promoter: 69920792 - 69922792 | Agilent_014791_44K |