| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 182 |
Name | JAG1 |
Synonymous | jagged 1;JAG1;jagged 1 |
Definition | protein jagged-1 |
Position | 20p12.1-p11.23 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Jagged1(h) --> Notch1EC(m):Notch1TM(m) (activation) | Jagged1(h) --> Notch1TM(h):Notch1EC(h) (activation) | 2 NDP-Gly + Jagged1(h) --Mfng(m)--> NMP + NDP + Jagged1(h){gly(n)S/T} (O-glycosylation) | JAG1(h) --> Jagged1(h) (expression). | Jagged1(h) --> loricrin(h) (increase of abundance) | Jagged1(h) --> involucrin(h) (increase of abundance) | Jagged1(h) --> NF-kappaB1(h) (increase of abundance) | Jagged1(h) --> RelA-p65(h) (increase of abundance) | Jagged1(h) --/ IkappaB-alpha(h) (decrease of abundance) | Jagged1(h) --/ IkappaB-beta(h) (decrease of abundance) | Jagged1(h) --/ Notch1(h) (decrease of abundance) | Jagged1(h) --> IkappaB-alpha(m.s.){p} (increase of phosphorylation) | Jagged1(h) --> PPARgamma(h) (increase of abundance) | Jagged1(h) --> PPARalpha(h) (increase of abundance) | Jagged1(h) --> PPARalpha(h):RelA-p65(h) (increase of binding) | JAG1(h) --> Jagged1(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 143 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 217 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 382 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 559 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 745 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 960 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 991 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1045 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1064 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr20 |
Promoter: 10602090 - 10604090 | Agilent_014791 |
chr20 |
Promoter: 10602090 - 10604090 | GoldenGate_Methylation_Cancer_Panel_I |
chr20 |
Promoter: 10602090 - 10604090 | GSE27584 |
chr20 |
Promoter: 10602090 - 10604090 | Agilent_014791_44K |
chr20 |
Promoter: 10602090 - 10604090 | Agilent_014791 |