| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1495 |
Name | CTNNA1 |
Synonymous | catenin (cadherin-associated protein), alpha 1, 102kDa;CTNNA1;catenin (cadherin-associated protein), alpha 1, 102kDa |
Definition | alpha E-catenin|alpha-E-catenin|alpha-catenin|alphaE-catenin|cadherin-associated protein,102kDa|catenin alpha-1|renal carcinoma antigen NY-REN-13 |
Position | 5q31.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | alpha-catenin1(h) + beta-catenin(h) + E-cadherin(h) + p120CAS(h) + plakoglobin(h) <==> alpha-catenin1(h):beta-catenin(h):E-cadherin(h):plakoglobin(h):p120CAS(h) (binding) | alpha-catenin1(h) + beta-catenin(h) <==> alpha-catenin1(h):beta-catenin(h) (binding) | alpha-catenin1(h) + apc(h) + beta-catenin(h) + plakoglobin(h) <==> alpha-catenin1(h):apc(h):beta-catenin(h):plakoglobin(h) (binding) | ErbB2(h) + alpha-catenin1(h) <==> alpha-catenin1(h):ErbB2(h) (binding) | alpha-catenin1(h) + beta-catenin(h){pY} + E-cadherin(h) + LAR(h) + plakoglobin(h){pY} <==> alpha-catenin1(h):beta-catenin(h){pY}:E-cadherin(h):plakoglobin(h){pY}:LAR(h) (binding) | alpha-catenin1(h) + plakoglobin(h){pY549} <==> alpha-catenin1(h):plakoglobin(h){pY549} (binding) | alpha-catenin1(h) + IGF-1R(h){pY} <==> alpha-catenin1(h):IGF-1R(h){pY} (binding) | alpha-catenin1(h) + IGF-1R(h){pY} <==> alpha-catenin1(h):IGF-1R(h){pY} (binding) | alpha-catenin1(h) + E-cadherin(h){pY} <==> alpha-catenin1(h):E-cadherin(h){pY} (binding) | alpha-catenin1(h) + zo-1(h){pY} <==> alpha-catenin1(h):zo-1(h){pY} (binding) | alpha-catenin1(h) + actin(h) <==> alpha-catenin1(h):actin(h) (binding) | alpha-catenin1(h):beta-catenin(h){pY}:E-cadherin(h):plakoglobin(h){pY}:p120CAS(h){pY} <==> alpha-catenin1(h) + beta-catenin(h){pY}:E-cadherin(h):plakoglobin(h){pY}:p120CAS(h){pY} (dissociation) | CTNNA1(h) --> alpha-catenin1(h) (expression). | CTNNA1(h) --> alpha-catenin1-isoform1(h) (expression). | CTNNA1(h) --> alpha-catenin1-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 641 | Phosphoserine. | Swiss-Prot 53.0 | 652 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 654 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 655 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 658 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 641 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr5 |
Promoter: 138115506 - 138117506 | Agilent_014791 |
chr5 |
Promoter: 138115506 - 138117506 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 138115506 - 138117506 | GSE27584 |
chr5 |
Promoter: 138115506 - 138117506 | Agilent_014791_44K |