| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 1386 |
Name | ATF2 |
Synonymous | activating transcription factor 2;ATF2;activating transcription factor 2 |
Definition | activating transcription factor 2 splice variant ATF2-var2|cAMP response element-binding protein CRE-BP1|cAMP responsive element binding protein 2, formerly|cAMP-dependent transcription factor ATF-2|cAMP-responsive element-binding protein 2|cyclic AMP-dep |
Position | 2q32 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ATF-2-xbb4(h) + ATP --p38beta2(h){p}--> ATF-2-xbb4(h){p} + ADP (phosphorylation) | ATF-2-xbb4(h) + ATP --p38gamma(r){p}--> ATF-2-xbb4(h){p} + ADP (phosphorylation) | ATF-2-xbb4(h) + ATP --p38alpha(m){p}--> ATF-2-xbb4(h){p} + ADP (phosphorylation) | ATF-2-xbb4(h) + ATP --p38alpha(x){p}--> ATF-2-xbb4(h){p} + ADP (phosphorylation) | ATF-2-xbb4(h) --> POLB(h) (DNA binding). | ATF-2-xbb4(h) --> E3(AD) (DNA binding). | ATF-2-xbb4(h) --> E4(AD) (DNA binding). | ATF-2-xbb4(h) --> FN1(h) (DNA binding). | ATF-2-xbb4(h) --> FOS(h) (DNA binding). | ATF-2-xbb4(h) --> Fos(m) (DNA binding). | ATF-2-xbb4(h) --> CGA(h) (DNA binding). | ATF-2-xbb4(h) --> HTLV-I(HT1) (DNA binding). | ATF-2-xbb4(h) --> IE-1(HCMV) (DNA binding). | ATF-2-xbb4(h) --> H2-Aa(m) (DNA binding). | ATF-2-xbb4(h) --> ENK(h) (DNA binding). | ATF-2-xbb4(h) --> Sst(r) (DNA binding). | ATF-2-xbb4(h) --> SV40(sv) (DNA binding). | ATF-2-xbb4(h) --> VIP(h) (DNA binding). | ATF-2-xbb4(h) --> ATF2(h) (DNA binding). | ATF-2-xbb4(h) --> TGFB2(h) (DNA binding). | ATF-2-xbb4(h) --> tPA(h) (DNA binding). | ATF-2-xbb4(h) --> HBV enhancer(HBV) (DNA binding). | ATF-2-xbb4(h) --> uPA(h) (DNA binding). | ATF(h) + ATF-2-xbb4(h) <==> ATF(h):ATF-2-xbb4(h) (binding). | c-Fos(h) + ATF-2-xbb4(h) <==> c-Fos(h):ATF-2-xbb4(h) (binding). | c-Jun(m) + ATF-2-xbb4(h) <==> c-Jun(m):ATF-2-xbb4(h) (binding). | c-Jun(r) + ATF-2-xbb4(h) <==> c-Jun(r):ATF-2-xbb4(h) (binding). | c-Jun(h) + ATF-2-xbb4(h) <==> c-Jun(h):ATF-2-xbb4(h) (binding). | c-Jun(c) + ATF-2-xbb4(h) <==> c-Jun(c):ATF-2-xbb4(h) (binding). | c-Jun(HA) + ATF-2-xbb4(h) <==> c-Jun(HA):ATF-2-xbb4(h) (binding). | ATF-2-isoform2(m) + ATF-2-xbb4(h) <==> ATF-2-xbb4(h):ATF-2-isoform2(m) (binding). | pRb(h) + ATF-2-xbb4(h) <==> pRb(h):ATF-2-xbb4(h) (binding). | NF-kappaB1-p50(h) + ATF-2-xbb4(h) <==> NF-kappaB1-p50(h):ATF-2-xbb4(h) (binding). | RelA-p65(h) + ATF-2-xbb4(h) <==> RelA-p65(h):ATF-2-xbb4(h) (binding). | Tax(HT1) + ATF-2-xbb4(h) <==> Tax(HT1):ATF-2-xbb4(h) (binding). | E1A 12S protein(AD) + ATF-2-xbb4(h) <==> E1A 12S protein(AD):ATF-2-xbb4(h) (binding). | CREBPA(h) + ATF-2-xbb4(h) <==> CREBPA(h):ATF-2-xbb4(h) (binding). | ATF-3(h) + ATF-2-xbb4(h) <==> ATF-3(h):ATF-2-xbb4(h) (binding). | pX(HBV) + ATF-2-xbb4(h) <==> pX(HBV):ATF-2-xbb4(h) (binding). | Fra-2(h) + ATF-2-xbb4(h) <==> Fra-2(h):ATF-2-xbb4(h) (binding). | HMGIY-isoform2(h) + ATF-2-xbb4(h) <==> HMGIY-isoform2(h):ATF-2-xbb4(h) (binding). | ATF-2-xbb4(h) --> SELE(h) (DNA binding). | ATF-2-xbb4(h) --> CCNA2(h) (DNA binding). | ATF-2-xbb4(h) --> RB1(h) (DNA binding; transactivation). | ATF-2-xbb4(h) --> ATF3(h) (DNA binding). | c-Fos(m) + ATF-2-xbb4(h) <==> c-Fos(m):ATF-2-xbb4(h) (binding). | ATF-2-xbb4(h) + ATF-2-xbb4(h) <==> ATF-2-xbb4(h):ATF-2-xbb4(h) (binding). | E1A 13S protein(AD2) + ATF-2-xbb4(h) <==> E1A 13S protein(AD2):ATF-2-xbb4(h) (binding). | ATF-2-xbb4(h) + ATP --p38alpha(h)--> ATF-2-xbb4(h){p} + ADP (phosphorylation) | ATF-2-xbb4(h) + ATP --p38(h)--> ATF-2-xbb4(h){p} + ADP (phosphorylation) | ATF-2-xbb4(h) --> TNF(h) (transactivation). | ATF-2-xbb4(h) --> IFNB1(h) (DNA binding; transactivation). | ATF-2-xbb4(h) --> CCL5(h) (DNA binding). | topoisomerase-II-alpha(h) + ATF-2-xbb4(h) <==> topoisomerase-II-alpha(h):ATF-2-xbb4(h) (binding) | C/EBPgamma(h) + ATF-2-xbb4(h) <==> C/EBPgamma(h):ATF-2-xbb4(h) (binding) | CHOP-10(h) + ATF-2-xbb4(h) <==> CHOP-10(h):ATF-2-xbb4(h) (binding) | ATF-2-xbb4(h) + ATFa-isoform3(h) <==> ATF-2-xbb4(h):ATFa-isoform3(h) (binding) | ATF-2-xbb4(h) + c-Jun(h) <==> ATF-2-xbb4(h):c-Jun(h) (binding) | ATF-2-xbb4(h) + JunB(h) <==> ATF-2-xbb4(h):JunB(h) (binding) | ATF-2-xbb4(h) + JunD(h) <==> ATF-2-xbb4(h):JunD(h) (binding) | ATF-2-xbb4(h) + c-Fos(h) <==> ATF-2-xbb4(h):c-Fos(h) (binding) | ATF-2-xbb4(h) + FosB(h) <==> ATF-2-xbb4(h):FosB(h) (binding) | ATF-2-xbb4(h) + Fra-2(h) <==> ATF-2-xbb4(h):Fra-2(h) (binding) | ATF-2-xbb4(h) + ATF-3(h) <==> ATF-2-xbb4(h):ATF-3(h) (binding) | CREBPA-Alpha(h) + ATF-2-xbb4(h) <==> CREBPA-Alpha(h):ATF-2-xbb4(h) (binding) | Fra-1(h) + ATF-2-xbb4(h) <==> Fra-1(h):ATF-2-xbb4(h) (binding) | ATF-2-xbb4(h) + B-ATF(h) <==> ATF-2-xbb4(h):B-ATF(h) (binding) | ATF-2-xbb4(h) + batf3(h) <==> ATF-2-xbb4(h):batf3(h) (binding) | ATF-2-xbb4(h) + Bach1(h) <==> ATF-2-xbb4(h):Bach1(h) (binding) | ATF2(h) --> ATF-2-xbb4(h) (expression). | ATF2(h) --> ATF-2-isoform2(h) (expression). | ATF-2(h) + c-Fos(m) <==> ATF-2(h):c-Fos(m) (binding). | ATF-2(h) + c-Jun(h) <==> ATF-2(h):c-Jun(h) (binding). | ATF-2(h) --> SP-B(rb) (DNA binding). | ATF-2(h) --> TNF(h) (DNA binding; transactivation). | YY1(h) + ATF-2(h) <==> YY1(h):ATF-2(h) (binding) | CKII-alpha(h) + ATF-2(h) <==> CKII-alpha(h):ATF-2(h) (binding) | ATF-2(h) --> CYP11B1(h) (DNA binding). | CBP(h) + ATF-2(h) <==> CBP(h):ATF-2(h) (binding) | ATF-2(h) + ATP --JNK1alpha1(h)--> ATF-2(h){p} + ADP (phosphorylation) | ATF-2(h) + ATP --JNK2alpha-2(h)--> ATF-2(h){p} + ADP (phosphorylation) | ATF-2(h) --> CD1A(h) (DNA binding). | ATF-2(h) --> INS(h) (DNA binding; transactivation). | ATF-2(h) + Oct-1(h) <==> ATF-2(h):Oct-1(h) (binding) | ATF-2(h) + NF-IX(h) <==> ATF-2(h):NF-IX(h) (binding) | ATF-2(h) + ATP --> ATF-2(h){p} + ADP (phosphorylation) | ATF-2(h) --> CYP11A1(h) (DNA binding). | ATF-2(h) --> PBK(h) (DNA binding). | ATF-2(h) --> CYP19A1(h) (DNA binding). | ATF-2(h) + ATP --> ATF-2(h){pT} + ADP (phosphorylation) | ATF-2(h) --> CCND1(h) (DNA binding). | ATF-2(h) --> PTGS2(h) (DNA binding). | ATF-2(h) --> MMP2(h) (DNA binding). | ATF-2(h) --> SSTR2(r) (DNA binding). | CREB1(h) + ATF-2(h) <==> CREB1(h):ATF-2(h) (binding) | ATF-2(h) --> IFNG(h) (DNA binding). | ATF-2(h) --> EGR1(h) (DNA binding). | ATF-2(h) + ATP --> ATF-2(h){pT71} + ADP (phosphorylation) | ATF-2(h) --> Pck1(r) (DNA binding). | ATF-2(h) --> GAPDH(h) (DNA binding). | ATF-2(h) --> FASLG(h) (DNA binding). | ATF-2(h) --> ITGB8(h) (DNA binding). | ATF2(h) --> ATF-2(h) (expression). | ATF-2-isoform1(h) + ATP --> ATF-2-isoform1(h){pT} + ADP (phosphorylation) | ATF-2-isoform1(h) + ATP --p38alpha(h)--> ATF-2-isoform1(h){pT71} + ADP (phosphorylation) | ATF2(h) --> ATF-2-isoform1(h) (expression). | ATF2(h) --> ATF-2-xbb3(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 51 | Phosphothreonine (by MAPK14). | Swiss-Prot 53.0 | 53 | Phosphothreonine (by MAPK14). | Swiss-Prot 53.0 | 94 | Phosphoserine. | Swiss-Prot 53.0 | 94 | Phosphoserine | 15302935;17081983 | Phospho.ELM 6.0 | 472 | Phosphoserine (ATM) | 15916964 | Phospho.ELM 6.0 | 480 | Phosphoserine (ATM) | 15916964 | Phospho.ELM 6.0 | 55 | Phosphothreonine (VRK1) | 15105425 | Phospho.ELM 6.0 | 51 | Phosphothreonine (MAPK14;MAPK8) | 10777545;7535770;17081983 | Phospho.ELM 6.0 | 53 | Phosphothreonine (MAPK14;MAPK8) | 11971971;11896587;17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 175740643 - 175742643 | Agilent_014791 |
chr2 |
Promoter: 175740643 - 175742643 | GSE27584 |
chr2 |
Promoter: 175740643 - 175742643 | Agilent_014791_44K |